EP300 and TCF7L2

Number of citations of the paper that reports this interaction (PMID 12861022)
20

Data Source:
HPRD (in vivo, in vitro)

		EP300	TCF7L2
Gene Name		E1A binding protein p300	transcription factor 7-like 2 (T-cell specific, HMG-box)
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Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm PML Body Protein-DNA Complex Beta-catenin-TCF7L2 Complex
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Activating Transcription Factor Binding P53 Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding Beta-catenin Binding Transcription Factor Binding Zinc Ion Binding Acetyltransferase Activity Transferase Activity, Transferring Acyl Groups Chromatin DNA Binding Activating Transcription Factor Binding Nuclear Hormone Receptor Binding Androgen Receptor Binding Pre-mRNA Intronic Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding Nuclear Hormone Receptor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Gamma-catenin Binding Armadillo Repeat Domain Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Response To Hypoxia Somitogenesis Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Internal Protein Amino Acid Acetylation Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Notch Signaling Pathway Nervous System Development Heart Development Skeletal Muscle Tissue Development Circadian Rhythm Organ Morphogenesis Viral Process N-terminal Peptidyl-lysine Acetylation Internal Peptidyl-lysine Acetylation Lung Development Positive Regulation Of Protein Binding Positive Regulation Of Type I Interferon Production Cellular Response To Heat Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To Estrogen Positive Regulation By Host Of Viral Transcription Histone H4 Acetylation Histone H2B Acetylation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Cycle Regulation Of Androgen Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Regulation Of Tubulin Deacetylation Regulation Of Cellular Response To Heat	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Glycogen Metabolic Process Glucose Metabolic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Arrest Brain Development Cell Proliferation Cellular Response To Starvation Response To Glucose Post-embryonic Development Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Oligodendrocyte Development Neural Tube Development Pituitary Gland Development Bone Mineralization Negative Regulation Of BMP Signaling Pathway Embryonic Genitalia Morphogenesis Pancreas Development Regulation Of Myelination Positive Regulation Of Insulin Secretion Positive Regulation Of Protein Binding Secretory Granule Localization Regulation Of Hormone Metabolic Process Somatic Stem Cell Maintenance Multicellular Organism Growth Catenin Import Into Nucleus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Maintenance Of DNA Repeat Elements Skin Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Organ Growth Positive Regulation Of Protein Export From Nucleus Embryonic Digestive Tract Morphogenesis Embryonic Hindgut Morphogenesis Myoblast Fate Commitment Regulation Of Skeletal Muscle Tissue Development Regulation Of Smooth Muscle Cell Proliferation Generation Of Neurons Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Face Morphogenesis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Insulin Metabolic Process Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Metabolism of lipids and lipoproteins Signaling by Wnt NOTCH2 intracellular domain regulates transcription Regulation of gene expression by Hypoxia-inducible Factor Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Pre-NOTCH Transcription and Translation RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 in Cancer Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex Factors involved in megakaryocyte development and platelet production Chromatin modifying enzymes LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Signaling by NOTCH1 PEST Domain Mutants in Cancer Mitotic G2-G2/M phases Constitutive Signaling by NOTCH1 PEST Domain Mutants PPARA activates gene expression Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Attenuation phase G2/M Transition HATs acetylate histones RORA activates circadian gene expression HSF1-dependent transactivation TRAF3-dependent IRF activation pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation XAV939 inhibits tankyrase, stabilizing AXIN Pre-NOTCH Expression and Processing Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Innate Immune System Fatty acid, triacylglycerol, and ketone body metabolism Cytosolic sensors of pathogen-associated DNA Cellular response to heat stress REV-ERBA represses gene expression Cell Cycle, Mitotic RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways NOTCH1 Intracellular Domain Regulates Transcription TCF dependent signaling in response to WNT TRAF6 mediated IRF7 activation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Signaling by WNT in cancer BMAL1:CLOCK,NPAS2 activates circadian gene expression Polo-like kinase mediated events	APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt binding of TCF/LEF:CTNNB1 to target gene promoters deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Peptide hormone metabolism Degradation of beta-catenin by the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Incretin synthesis, secretion, and inactivation truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes beta-catenin independent WNT signaling deletions in the AMER1 gene destabilize the destruction complex Ca2+ pathway AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Drugs
Diseases
GWAS		Crohn's disease ( 22936669)	Breast cancer ( 23535729) Breast Cancer in BRCA1 mutation carriers ( 23544013) Coronary heart disease ( 21347282) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting insulin-related traits (interaction with BMI) ( 22581228) Glycated hemoglobin levels ( 20849430) Metabolic syndrome ( 20694148) Proinsulin levels ( 21873549) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 17668382 18372903 17293876 22693455 17554300 23300278 20581827 19401414 17463246 17463248 17463249 22101970 17460697 19056611 23209189) Type 2 diabetes and other traits ( 19734900)
Protein-Protein Interactions		344 interactors: ABL1 ACSM5 ACTA2 ACTB AHR AKT1 ALX1 APEX1 AR ARNT ARNTL ARSF ASCL1 ASH2L ATF5 ATR BAG6 BCAS2 BCL3 BCL6 BRCA1 BRMS1 C1R CALCOCO1 CARM1 CCNB1 CCND1 CDK1 CDK2 CDKN1A CDT1 CDX2 CEBPA CEBPB CEBPD CFH CHD4 CITED1 CITED2 CITED4 CLOCK CLTC CNOT4 CNTN2 COPS2 COPS6 CREB1 CREBBP CRX CTBP1 CTBP2 CTF1 CTNNB1 CXCL8 CXXC1 DAO DBP DDIT3 DDX24 DDX5 DECR2 DEK DTX1 E2F5 EGR1 EID1 EID2 ELF3 ELK1 EMB EPAS1 EPO ESR1 ESR2 ETS1 ETS2 ETV1 ETV4 EWSR1 FBXL5 FEN1 FHL2 FOSB FOSL1 FOSL2 FOXO1 FOXO3 FOXP3 GAA GABPA GATA2 GATA4 GATA5 GATA6 GOLGA2 GPBP1 GPS2 GRB2 GRIP1 GTF2B HAND2 HBP1 HDAC1 HDAC3 HDAC6 HERC1 HIF1A HIPK2 HIST1H1A HIST1H1D HIST1H2AB HIST1H2BB HIST1H3A HIST1H4A HIST2H2AB HIST2H2AC HIST2H2BE HIST2H3C HIST2H4A HIST3H3 HIST4H4 HMGN1 HMGN2 HNF1A HNRNPU HNRNPUL1 HOXA10 HOXB1 HOXB2 HOXB3 HOXB4 HOXB6 HOXB7 HOXB9 HOXD10 HOXD4 HPS6 HSP90AA2P IMMT ING1 ING2 ING4 ING5 IRF1 IRF2 IRF3 IRF5 IRF7 ITIH3 JDP2 JMY JUN JUNB JUND KAT2A KAT2B KAT5 KCTD5 KLF1 KLF13 KLF2 KLF4 KLF5 KPNA2 KRT18 LEF1 MAF MAGED1 MAML1 MAP2K1 MAP3K5 MAPK1 MAPK8 MAPT MAX MCM3AP MDC1 MDM2 MDM4 MEF2A MEF2C MEF2D MGMT MITF MN1 MPG MRE11A MSH6 MSTO1 MYB MYBL2 MYC MYOD1 N4BP2 NAP1L1 NAP1L4 NBN NCOA1 NCOA2 NCOA3 NCOA6 NEDD1 NEIL2 NEUROD1 NFATC1 NFATC2 NFKB1 NFYB NOTCH1 NOXA1 NPAS2 NPM1 NR1H4 NR2F2 NR4A1 NUP98 NUPR1 NUTM1 OLIG2 PAK2 PAX5 PAX6 PAX8 PAXIP1 PCK2 PCNA PDHX PELP1 PIAS3 PIN1 PLAGL1 PLG PLSCR1 PLSCR2 PML POLB POLD2 POU3F2 PPARA PPARD PPARG PPP2R5C PRKCA PRKCB PRKCD PROX1 PTMA RAD23A RAD50 RAN RB1 RBM14 RECQL4 REL RELA RORA RPL27 RPS6KA5 RPS6KB1 RPS6KB2 RUNX1 RUNX2 RUNX3 SATB1 SAV1 SENP3 SEPP1 SERTAD1 SET SETD1A SGCG SIRT1 SIRT2 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD7 SNIP1 SNW1 SOX9 SP1 SP3 SPHK1 SPIB SRC SREBF2 SRY SS18 SS18L1 STAT1 STAT2 STAT3 STAT5A STAT5B STAT6 SUB1 SUV39H1 TACC2 TADA3 TAF1B TAL1 TCF12 TCF3 TCF4 TCF7L2 TDG TERF2 TFAP2A TGFB1I1 TGS1 THPO TINAGL1 TNIP2 TP53 TP53BP1 TP63 TP73 TRAF2 TRERF1 TRIP4 TSG101 TWIST1 UBE2D1 UBE2I UBQLN1 USF2 VPS18 WDR59 WDR82 XRCC6 YY1 ZBTB16 ZBTB17 ZBTB48 ZBTB7B ZBTB8A ZC3H12A ZEB1 ZFPM2 ZNF148 ZNF76 ZRANB2	13 interactors: CSNK2A1 CSNK2A2 CTBP1 CTNNB1 CTNNBIP1 DAXX DAZAP2 EP300 FBLN1 JUP PSEN1 PSMA3 UBE2I
Entrez ID		2033	6934
HPRD ID		04078	03751
Ensembl ID		ENSG00000100393	ENSG00000148737
Uniprot IDs		Q09472 Q7Z6C1	B4DJZ2 B4DRJ8 B7Z9Z6 B9X074 C6ZRJ7 C6ZRJ8 C6ZRJ9 C6ZRK0 C6ZRK1 C6ZRK2 C6ZRK5 E2GH13 E2GH14 E2GH16 E2GH18 E2GH24 E2GH25 E2GH26 Q6FHW4 Q9NQB0
PDB IDs		1L3E 1P4Q 2K8F 3BIY 3I3J 3IO2 3P57 3T92 4BHW	1JDH 1JPW 2GL7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Response To Organic Substance Cell Differentiation Regulation Of Cell Differentiation Developmental Process Regulation Of Cell Proliferation Anatomical Structure Development Multicellular Organismal Development Cellular Response To Organic Substance System Development Cellular Response To Stress Response To Stress Regulation Of Cellular Process Tissue Development	Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Viral Process Apoptotic Process Wnt Signaling Pathway Programmed Cell Death Cell Cycle Process Cell Death Death Regulation Of Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Process Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Mitotic Cell Cycle Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Cell Cycle Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process Cellular Response To Indole-3-methanol Regulation Of Chromosome Organization Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Anterior/posterior Pattern Specification Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Regulation Of Proteolysis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process
Tagcloud ?		ache ahr antimirs arguing cholinergic cns correlates creb detrusor influences jarid1a limits mecp2 micrornas mimics mir mirna mirnas nuclei obstruction outlet outside plasticity pnkd referenced synapse transfection unrelated urethra	3a adenovirus bidirectional c57bl cat complexities consequence exploration foxo foxo1 gluconeogenesis gluconeogenic hepatic hepatocytes ltcfdn mechanistic opposing opposite pck1 picture preferential pyruvate redundant repressive suppressing views wnt
Tagcloud (Difference) ?		ache ahr antimirs arguing cholinergic cns correlates creb detrusor influences jarid1a limits mecp2 micrornas mimics mir mirna mirnas nuclei obstruction outlet outside plasticity pnkd referenced synapse transfection unrelated urethra	3a adenovirus bidirectional c57bl cat complexities consequence exploration foxo foxo1 gluconeogenesis gluconeogenic hepatic hepatocytes ltcfdn mechanistic opposing opposite pck1 picture preferential pyruvate redundant repressive suppressing views wnt
Tagcloud (Intersection) ?