SLX1A and ERCC4

Number of citations of the paper that reports this interaction (PMID 19596236)
118

Data Source:
BioGRID (pull down)

		SLX1A	ERCC4
Gene Name		SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)	excision repair cross-complementation group 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Slx1-Slx4 Complex	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Transcription Factor TFIID Complex
	Molecular Function	Protein Binding Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Metal Ion Binding	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Binding Damaged DNA Binding Single-stranded DNA Binding Endodeoxyribonuclease Activity Protein Binding Protein C-terminus Binding Structure-specific DNA Binding Protein N-terminus Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing	Resolution Of Meiotic Recombination Intermediates Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Response To UV UV Protection Telomere Maintenance Via Telomere Shortening Negative Regulation Of Telomere Maintenance Nucleotide-excision Repair, DNA Incision Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways			Nucleotide Excision Repair Global Genomic NER (GG-NER) Transcription-coupled NER (TC-NER) Formation of incision complex in GG-NER Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in GG-NER Dual incision reaction in TC-NER
Drugs
Diseases
GWAS			Bilirubin levels ( 22085899) Conduct disorder (symptom count) ( 20585324) Metabolic syndrome ( 20694148)
Protein-Protein Interactions		6 interactors: EME1 ERCC1 ERCC4 GRB2 MUS81 SLX4	7 interactors: ERCC1 FANCG GTF2H1 RAD52 SLX1A SLX4 SPTAN1
Entrez ID		548593	2072
HPRD ID		18681	00594
Ensembl ID		ENSG00000132207	ENSG00000175595
Uniprot IDs		Q9BQ83	Q92889
PDB IDs			1Z00 2A1J 2AQ0 2KN7
Enriched GO Terms of Interacting Partners?		Response To Intra-S DNA Damage Checkpoint Signaling DNA Recombination Cellular Response To DNA Damage Stimulus Nucleic Acid Phosphodiester Bond Hydrolysis DNA Catabolic Process, Endonucleolytic DNA Catabolic Process DNA Repair Cellular Response To Stress Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision DNA Metabolic Process Nucleotide-excision Repair Interstrand Cross-link Repair Aromatic Compound Catabolic Process Negative Regulation Of Telomere Maintenance UV Protection Double-strand Break Repair Nucleotide-excision Repair, DNA Damage Removal Regulation Of Telomere Maintenance Response To Stress Cellular Macromolecule Catabolic Process Transcription-coupled Nucleotide-excision Repair Response To Radiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Catabolic Process Response To UV Cellular Response To Stimulus Response To Ionizing Radiation Response To Biotic Stimulus Post-embryonic Hemopoiesis DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Via Telomere Shortening Pyrimidine Dimer Repair By Nucleotide-excision Repair Regulation Of Organelle Organization Regulation Of Chromosome Organization Nucleobase-containing Compound Metabolic Process Replicative Cell Aging Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Stimulus Response To Abiotic Stimulus DNA Double-strand Break Processing Cellular Nitrogen Compound Metabolic Process Branching Involved In Labyrinthine Layer Morphogenesis Aging	DNA Repair Cellular Response To DNA Damage Stimulus DNA Catabolic Process Double-strand Break Repair DNA Metabolic Process DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing DNA Recombination Cellular Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleotide-excision Repair DNA Catabolic Process, Endonucleolytic DNA Double-strand Break Processing Aromatic Compound Catabolic Process Nucleotide-excision Repair, DNA Damage Removal DNA Catabolic Process, Exonucleolytic Cellular Macromolecule Catabolic Process Response To Stress Transcription-coupled Nucleotide-excision Repair Nucleic Acid Phosphodiester Bond Hydrolysis Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stimulus Post-embryonic Hemopoiesis Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nitrogen Compound Metabolic Process Catabolic Process Pyrimidine Dimer Repair By Nucleotide-excision Repair Response To Intra-S DNA Damage Checkpoint Signaling DNA Recombinase Assembly Gonad Development Nucleotide-excision Repair, DNA Incision Replicative Cell Aging Development Of Primary Sexual Characteristics Interstrand Cross-link Repair Germ Cell Development Cellular Response To Stimulus Negative Regulation Of Telomere Maintenance Sex Differentiation Pyrimidine Dimer Repair UV Protection Response To Sucrose Regulation Of Telomere Maintenance Response To Radiation Isotype Switching Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter
Tagcloud ?			additively additivity adducts african americans bonferroni bulky cancerous carolina corrected departures ds eradicate ercc2 hnc interacted jointly ner os platinum remove rs2607755 rs3136038 rs3136130 rs50871 suggestively uncorrected whites xpc
Tagcloud (Difference) ?			additively additivity adducts african americans bonferroni bulky cancerous carolina corrected departures ds eradicate ercc2 hnc interacted jointly ner os platinum remove rs2607755 rs3136038 rs3136130 rs50871 suggestively uncorrected whites xpc
Tagcloud (Intersection) ?