SLX1A and MUS81

Number of citations of the paper that reports this interaction (PMID 19596236)
118

Data Source:
BioGRID (pull down)

		SLX1A	MUS81
Gene Name		SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)	MUS81 structure-specific endonuclease subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Slx1-Slx4 Complex	Nucleus Nucleolus
	Molecular Function	Protein Binding Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Metal Ion Binding	DNA Binding Protein Binding Metal Ion Binding 3'-flap Endonuclease Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing	DNA Catabolic Process, Endonucleolytic DNA Repair DNA Recombination Response To Intra-S DNA Damage Checkpoint Signaling
Pathways
Drugs
Diseases
GWAS			Breast cancer ( 23535729)
Protein-Protein Interactions		6 interactors: EME1 ERCC1 ERCC4 GRB2 MUS81 SLX4	5 interactors: CHEK2 EME1 EME2 SLX1A SLX4
Entrez ID		548593	80198
HPRD ID		18681	09419
Ensembl ID		ENSG00000132207	ENSG00000172732
Uniprot IDs		Q9BQ83	Q53ES5 Q96NY9
PDB IDs			2MC3 2ZIX
Enriched GO Terms of Interacting Partners?		Response To Intra-S DNA Damage Checkpoint Signaling DNA Recombination Cellular Response To DNA Damage Stimulus Nucleic Acid Phosphodiester Bond Hydrolysis DNA Catabolic Process, Endonucleolytic DNA Catabolic Process DNA Repair Cellular Response To Stress Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision DNA Metabolic Process Nucleotide-excision Repair Interstrand Cross-link Repair Aromatic Compound Catabolic Process Negative Regulation Of Telomere Maintenance UV Protection Double-strand Break Repair Nucleotide-excision Repair, DNA Damage Removal Regulation Of Telomere Maintenance Response To Stress Cellular Macromolecule Catabolic Process Transcription-coupled Nucleotide-excision Repair Response To Radiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Catabolic Process Response To UV Cellular Response To Stimulus Response To Ionizing Radiation Response To Biotic Stimulus Post-embryonic Hemopoiesis DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Via Telomere Shortening Pyrimidine Dimer Repair By Nucleotide-excision Repair Regulation Of Organelle Organization Regulation Of Chromosome Organization Nucleobase-containing Compound Metabolic Process Replicative Cell Aging Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Stimulus Response To Abiotic Stimulus DNA Double-strand Break Processing Cellular Nitrogen Compound Metabolic Process Branching Involved In Labyrinthine Layer Morphogenesis Aging	DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Nucleic Acid Phosphodiester Bond Hydrolysis Response To Intra-S DNA Damage Checkpoint Signaling DNA Metabolic Process DNA Double-strand Break Processing Cellular Response To Stress Double-strand Break Repair DNA Catabolic Process, Exonucleolytic Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Catabolic Process, Endonucleolytic Signal Transduction Involved In Intra-S DNA Damage Checkpoint Nucleobase-containing Compound Metabolic Process DNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Catabolic Process Nitrogen Compound Metabolic Process Cellular Response To Stimulus Regulation Of Nuclear Cell Cycle DNA Replication Intra-S DNA Damage Checkpoint DNA Damage Induced Protein Phosphorylation Aromatic Compound Catabolic Process Replicative Senescence Catabolic Process Mitotic Spindle Assembly Response To Stimulus Mitotic Spindle Organization Response To Biotic Stimulus Negative Regulation Of DNA Replication Response To Gamma Radiation Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cellular Metabolic Process Cell Aging Spindle Assembly Protein Stabilization Signal Transduction In Response To DNA Damage Nucleotide-excision Repair Mitotic DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint
Tagcloud ?			adjacent analyze chinese clinicopathological colorectal correlated correlation correlations corresponding distant explore han marker markers metastasis nested normal parameters pattern profile progression quantitative real stage suggesting tissues tnm tumor value
Tagcloud (Difference) ?			adjacent analyze chinese clinicopathological colorectal correlated correlation correlations corresponding distant explore han marker markers metastasis nested normal parameters pattern profile progression quantitative real stage suggesting tissues tnm tumor value
Tagcloud (Intersection) ?