SLX1A

Description		structure-specific endonuclease subunit SLX1A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Slx1-Slx4 Complex
	Molecular Function	Nuclease Activity Endonuclease Activity Protein Binding Zinc Ion Binding Crossover Junction DNA Endonuclease Activity Hydrolase Activity 5'-flap Endonuclease Activity Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Via Telomere Lengthening Regulation Of Telomere Maintenance Telomeric D-loop Disassembly T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)
Interacting Genes		6 interacting genes: EME1 ERCC1 ERCC4 GRB2 MUS81 SLX4
Entrez ID		548593
HPRD ID		18681
Ensembl ID		ENSG00000132207
Uniprot IDs		Q9BQ83
PDB IDs
Enriched GO Terms of Interacting Partners?		Resolution Of Meiotic Recombination Intermediates ERCC4-ERCC1 Complex Telomere Maintenance Response To Intra-S DNA Damage Checkpoint Signaling Holliday Junction Resolvase Complex Telomere Organization Response To DNA Damage Checkpoint Signaling Double-strand Break Repair DNA Recombination Meiosis I Cell Cycle Process DNA Damage Response Chromosome Organization DNA Repair Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Telomeric DNA-containing Double Minutes Formation Nucleotide-excision Repair Factor 1 Complex Negative Regulation Of Protection From Non-homologous End Joining At Telomere Nucleotide-excision Repair Positive Regulation Of T-circle Formation Negative Regulation Of Telomere Maintenance In Response To DNA Damage 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Cellular Response To Stress Endodeoxyribonuclease Complex DNA Metabolic Process Resolution Of Mitotic Recombination Intermediates Nucleotide-excision Repair Complex Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Capping Resolution Of DNA Recombination Intermediates Crossover Junction DNA Endonuclease Activity Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding Regulation Of Telomere Maintenance T-circle Formation UV Protection Nuclease Activity Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Recombination Regulation Of Telomere Capping Double-strand Break Repair Via Homologous Recombination Organelle Organization Recombinational Repair Signal Transduction In Response To DNA Damage Mitotic Intra-S DNA Damage Checkpoint Signaling Reproductive Process Mitotic Recombination Nuclear Replication Fork Cellular Response To Radiation DNA Endonuclease Activity
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