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SLX1A and SLX4
Number of citations of the paper that reports this interaction (PMID
19596236
)
118
Data Source:
BioGRID
(affinity chromatography technology, imaging technique)
HPRD
(two hybrid)
SLX1A
SLX4
Gene Name
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
SLX4 structure-specific endonuclease subunit
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Slx1-Slx4 Complex
Nuclear Chromosome, Telomeric Region
Nuclear Chromatin
Nucleoplasm
Cytoplasm
Cell Junction
Slx1-Slx4 Complex
Holliday Junction Resolvase Complex
ERCC4-ERCC1 Complex
Molecular Function
Protein Binding
Crossover Junction Endodeoxyribonuclease Activity
5'-flap Endonuclease Activity
Metal Ion Binding
Protein Binding
Enzyme Activator Activity
Crossover Junction Endodeoxyribonuclease Activity
5'-flap Endonuclease Activity
3'-flap Endonuclease Activity
Biological Process
Double-strand Break Repair Via Homologous Recombination
DNA Catabolic Process, Endonucleolytic
DNA Repair
DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing
Double-strand Break Repair Via Homologous Recombination
DNA Catabolic Process, Endonucleolytic
DNA Replication
DNA Repair
Nucleotide-excision Repair
DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing
Positive Regulation Of Catalytic Activity
Response To Intra-S DNA Damage Checkpoint Signaling
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions
6 interactors:
EME1
ERCC1
ERCC4
GRB2
MUS81
SLX4
7 interactors:
APP
EME1
ERCC4
MUS81
SLX1A
SLX4IP
UBC
Entrez ID
548593
84464
HPRD ID
18681
12537
Ensembl ID
ENSG00000132207
ENSG00000188827
Uniprot IDs
Q9BQ83
Q8IY92
PDB IDs
4M7C
Enriched GO Terms of Interacting Partners
?
Response To Intra-S DNA Damage Checkpoint Signaling
DNA Recombination
Cellular Response To DNA Damage Stimulus
Nucleic Acid Phosphodiester Bond Hydrolysis
DNA Catabolic Process, Endonucleolytic
DNA Catabolic Process
DNA Repair
Cellular Response To Stress
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision
DNA Metabolic Process
Nucleotide-excision Repair
Interstrand Cross-link Repair
Aromatic Compound Catabolic Process
Negative Regulation Of Telomere Maintenance
UV Protection
Double-strand Break Repair
Nucleotide-excision Repair, DNA Damage Removal
Regulation Of Telomere Maintenance
Response To Stress
Cellular Macromolecule Catabolic Process
Transcription-coupled Nucleotide-excision Repair
Response To Radiation
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Negative Regulation Of Chromosome Organization
Negative Regulation Of DNA Metabolic Process
Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Catabolic Process
Response To UV
Cellular Response To Stimulus
Response To Ionizing Radiation
Response To Biotic Stimulus
Post-embryonic Hemopoiesis
DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing
Telomere Maintenance Via Telomere Shortening
Pyrimidine Dimer Repair By Nucleotide-excision Repair
Regulation Of Organelle Organization
Regulation Of Chromosome Organization
Nucleobase-containing Compound Metabolic Process
Replicative Cell Aging
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Response To Stimulus
Response To Abiotic Stimulus
DNA Double-strand Break Processing
Cellular Nitrogen Compound Metabolic Process
Branching Involved In Labyrinthine Layer Morphogenesis
Aging
DNA Repair
DNA Recombination
Response To Intra-S DNA Damage Checkpoint Signaling
Cellular Response To DNA Damage Stimulus
Nucleic Acid Phosphodiester Bond Hydrolysis
DNA Metabolic Process
DNA Catabolic Process, Endonucleolytic
DNA Catabolic Process
Cellular Response To Stress
Response To Stress
Cellular Macromolecule Catabolic Process
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Aromatic Compound Catabolic Process
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Nitrogen Compound Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Regulation Of ERBB Signaling Pathway
Recombinational Repair
Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Catabolic Process
Cellular Response To Stimulus
Synaptic Growth At Neuromuscular Junction
Notch Signaling Pathway
Double-strand Break Repair
Collateral Sprouting In Absence Of Injury
DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Telomere Maintenance Via Telomere Shortening
Intracellular Receptor Signaling Pathway
Collateral Sprouting
Axon Midline Choice Point Recognition
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Phase Transition
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Axon Choice Point Recognition
Nucleotide-excision Repair, DNA Incision
Response To Stimulus
Response To Abiotic Stimulus
DNA Double-strand Break Processing
Positive Regulation Of Cell Cycle
Positive Regulation Of Proteolysis
Neuron Remodeling
Interstrand Cross-link Repair
Negative Regulation Of Telomere Maintenance
Tagcloud
?
btb
catastrophe
charged
conjugating
crosslink
detrimental
dispensable
e3
endonuclease
engages
ercc1
fanconi
fragile
instead
interacting
interstrand
ligase
mitotic
motifs
recombination
relies
remarkably
repair
sims
sumo
sumoylates
ubc9
ubz4
xpf
Tagcloud (Difference)
?
btb
catastrophe
charged
conjugating
crosslink
detrimental
dispensable
e3
endonuclease
engages
ercc1
fanconi
fragile
instead
interacting
interstrand
ligase
mitotic
motifs
recombination
relies
remarkably
repair
sims
sumo
sumoylates
ubc9
ubz4
xpf
Tagcloud (Intersection)
?