NR2F6 and NSD1

Number of citations of the paper that reports this interaction (PMID 23975195)
1

Data Source:
BioGRID (two hybrid)

		NR2F6	NSD1
Gene Name		nuclear receptor subfamily 2, group F, member 6	nuclear receptor binding SET domain protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Thyroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	Chromatin Binding Transcription Cofactor Activity Transcription Corepressor Activity Zinc Ion Binding Estrogen Receptor Binding Histone Methyltransferase Activity (H4-K20 Specific) Retinoic Acid Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Histone Methyltransferase Activity (H3-K36 Specific) Androgen Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Gene Expression Intracellular Receptor Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Steroid Hormone Mediated Signaling Pathway Neuron Development Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain	Negative Regulation Of Transcription From RNA Polymerase II Promoter Gastrulation With Mouth Forming Second Chromatin Organization Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Histone H4-K20 Methylation Positive Regulation Of Transcription, DNA-templated
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Activated partial thromboplastin time ( 22703881)
Protein-Protein Interactions		12 interactors: ANGPTL1 BCL11A CBX1 ESR1 NAP1L1 NCOA1 NR2F2 NR3C1 NSD1 RARG RXRA THRB	27 interactors: AR ATRX ESR1 ESRRA HIST1H1B HIST1H1C HIST1H1D HIST3H3 HIST4H4 HNF4G NR2E1 NR2F1 NR2F2 NR2F6 NR5A2 NR6A1 PPARG RARA RORA RORB RXRA SNORD3A THRA THRB TNFRSF21 VDR ZNF496
Entrez ID		2063	64324
HPRD ID		00583	09455
Ensembl ID		ENSG00000160113	ENSG00000165671
Uniprot IDs		B4DQE4 F1D8R3 P10588	Q96L73 Q96MN8
PDB IDs			3OOI
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Response To Steroid Hormone Positive Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Hormone Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Organic Cyclic Compound Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipid Negative Regulation Of Gene Expression Response To Lipid DNA-templated Transcription, Initiation Response To Organic Cyclic Compound Response To Hormone Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Reproductive Process Negative Regulation Of Biosynthetic Process Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Gland Development Reproductive Structure Development Reproductive System Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Epithelial Cell Differentiation Gene Expression Prostate Gland Development Reproduction Heterocycle Metabolic Process	Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Hormone Stimulus Transcription From RNA Polymerase II Promoter Response To Lipid Response To Organic Cyclic Compound Response To Hormone Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription, DNA-templated RNA Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Organ Development System Development
Tagcloud ?		another arp as4 augmented chip circ coup divergent ear2 effected enhancer exert hre huang initiating knocked liu luciferase negatively nr2f2 potently queues renin res screen sigmund surprisingly tfii twofold	abrogated af apo bifunctional box coactivators contains corepressors drosophila fingers fxxll helix holo interacts intermediary lbd lbds liganded lxxll nid nids nr nrs phd playing separate severely tr unliganded
Tagcloud (Difference) ?		another arp as4 augmented chip circ coup divergent ear2 effected enhancer exert hre huang initiating knocked liu luciferase negatively nr2f2 potently queues renin res screen sigmund surprisingly tfii twofold	abrogated af apo bifunctional box coactivators contains corepressors drosophila fingers fxxll helix holo interacts intermediary lbd lbds liganded lxxll nid nids nr nrs phd playing separate severely tr unliganded
Tagcloud (Intersection) ?