NR2F6 and BCL11A

Number of citations of the paper that reports this interaction (PMID 23975195)
1

Data Source:
BioGRID (two hybrid)

		NR2F6	BCL11A
Gene Name		nuclear receptor subfamily 2, group F, member 6	B-cell CLL/lymphoma 11A (zinc finger protein)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Thyroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Corepressor Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Gene Expression Intracellular Receptor Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Steroid Hormone Mediated Signaling Pathway Neuron Development Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Protein Sumoylation B Cell Differentiation T Cell Differentiation Negative Regulation Of Axon Extension Negative Regulation Of Protein Homooligomerization Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Collateral Sprouting Positive Regulation Of Collateral Sprouting Regulation Of Dendrite Development Negative Regulation Of Dendrite Development
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 22012869) Beta thalassemia/hemoglobin E disease ( 20183929) F-cell distribution ( 21326311 17767159) Fetal hemoglobin levels ( 18245381 20018918) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285) Mean corpuscular volume ( 19862010) Monocyte early outgrowth colony forming units ( 21493818) Red blood cell traits ( 23222517) Sickle cell anemia (haemolysis) ( 23406172) Type 2 diabetes ( 20581827)
Protein-Protein Interactions		12 interactors: ANGPTL1 BCL11A CBX1 ESR1 NAP1L1 NCOA1 NR2F2 NR3C1 NSD1 RARG RXRA THRB	20 interactors: ACTC1 APP BCL6 CDCA3 CDK4 CDK6 GMCL1P1 LMO1 NCK2 NR2E1 NR2E3 NR2F1 NR2F2 NR2F6 SIRT1 SUMO1 SUMO2 SUMO3 YME1L1 ZBTB24
Entrez ID		2063	53335
HPRD ID		00583	05949
Ensembl ID		ENSG00000160113	ENSG00000119866
Uniprot IDs		B4DQE4 F1D8R3 P10588	D6W5D9 D9YZV9 Q9H165
PDB IDs
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Response To Steroid Hormone Positive Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Hormone Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Organic Cyclic Compound Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipid Negative Regulation Of Gene Expression Response To Lipid DNA-templated Transcription, Initiation Response To Organic Cyclic Compound Response To Hormone Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Reproductive Process Negative Regulation Of Biosynthetic Process Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Gland Development Reproductive Structure Development Reproductive System Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Epithelial Cell Differentiation Gene Expression Prostate Gland Development Reproduction Heterocycle Metabolic Process	Positive Regulation Of Cellular Metabolic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Cellular Senescence Positive Regulation Of Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Aging Negative Regulation Of Cellular Metabolic Process Cell Differentiation Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Intracellular Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Senescence Protein Sumoylation Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Steroid Hormone Multicellular Organismal Development Generation Of Neurons Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Neurogenesis System Development Positive Regulation Of Proteolysis Positive Regulation Of Transcription, DNA-templated Organ Development Response To Hormone Protein Modification By Small Protein Conjugation Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Differentiation Forebrain Development Regulation Of Protein Metabolic Process Regulation Of Transcription, DNA-templated DNA-templated Transcription, Initiation Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		another arp as4 augmented chip circ coup divergent ear2 effected enhancer exert hre huang initiating knocked liu luciferase negatively nr2f2 potently queues renin res screen sigmund surprisingly tfii twofold	beadchip cpgs cues enhancers erythroblasts erythroid erythropoiesis fetal globin happen hbf hemoglobin highlighting humanmethylation illumina maps mendelian methylated methylation methylome moves overlap red repress sickle switch tend thalassemia unanticipated
Tagcloud (Difference) ?		another arp as4 augmented chip circ coup divergent ear2 effected enhancer exert hre huang initiating knocked liu luciferase negatively nr2f2 potently queues renin res screen sigmund surprisingly tfii twofold	beadchip cpgs cues enhancers erythroblasts erythroid erythropoiesis fetal globin happen hbf hemoglobin highlighting humanmethylation illumina maps mendelian methylated methylation methylome moves overlap red repress sickle switch tend thalassemia unanticipated
Tagcloud (Intersection) ?