EPHB6 and CRK

Number of citations of the paper that reports this interaction (PMID 11466354)
4

Data Source:
HPRD (in vivo)

		EPHB6	CRK
Gene Name		EPH receptor B6	v-crk avian sarcoma virus CT10 oncogene homolog
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Ephrin Receptor Activity ATP Binding	SH3/SH2 Adaptor Activity Protein Binding SH2 Domain Binding Protein Phosphorylated Amino Acid Binding Ephrin Receptor Binding
	Biological Process	Protein Phosphorylation Axon Guidance Ephrin Receptor Signaling Pathway	Activation Of MAPKK Activity Regulation Of Transcription From RNA Polymerase II Promoter Blood Coagulation Insulin Receptor Signaling Pathway Platelet Activation Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Rac Protein Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway
Pathways		EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	Signalling to ERKs Prolonged ERK activation events Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway Regulation of signaling by CBL Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Signaling by Insulin receptor Innate Immune System Signaling by PDGF Signalling by NGF Insulin receptor signalling cascade p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane ARMS-mediated activation Signaling by Interleukins Signal attenuation Signaling by VEGF Downstream signal transduction Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: CBL CRK CRKL EFNB2 EPHB1 GRB2 HDHD2 INCA1 MLLT4 NIF3L1 NOTCH2NL REL SAT1 TCF4 TRIM39	84 interactors: ABL1 ABL2 ARHGAP17 ARHGAP32 ASAP1 ATXN1 AVIL BCAR1 BCR BUB1 CBL CBLC CRKL DAB1 DOCK1 DOCK3 DOK1 DOK4 DPPA4 EFS EGFR EPHA3 EPHB2 EPHB3 EPHB6 EPS15 ERBB2 ERBB3 ERBB4 FAM154A FASLG FGFR1 FLT1 FRS2 FYN GAB1 GRB2 IGF1R INSR IRS1 IRS2 IRS4 KDR KHDRBS1 KIT MAP4K1 MAP4K5 MAPK4 MAPK8 MICAL1 NCK1 NEDD9 NTRK1 PDGFRA PDGFRB PIK3R1 PLSCR1 POT1 PPFIBP2 PPP1CA PSMC6 PTK2 PTK2B PTPN1 PTPN4 PXN RAPGEF1 REPS1 RET SH3BP1 SHB SHC1 SOCS1 SOS1 SPRR2A STAT5A STAT5B SYN1 TERF2IP VAV1 WASF1 WEE1 XPO1 ZAP70
Entrez ID		2051	1398
HPRD ID		04133	01267
Ensembl ID		ENSG00000106123	ENSG00000167193
Uniprot IDs		O15197	L7RT18 P46108
PDB IDs			1JU5 2DVJ 2EYV 2EYW 2EYX 2EYY 2EYZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Regulation Of Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Blood Vessel Development Vasculature Development Ephrin Receptor Signaling Pathway Signaling Cell Communication Positive Regulation Of Intracellular Signal Transduction Cardiovascular System Development Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Stimulus Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Cellular Process Activation Of MAPKK Activity Regulation Of Phosphorylation Regulation Of Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Angiogenesis Regulation Of ERBB Signaling Pathway Spermidine Acetylation Catenin Import Into Nucleus 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Axon Guidance Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Dihydrobiopterin Metabolic Process Putrescine Catabolic Process Cell-cell Signaling Blood Vessel Morphogenesis Response To Stimulus Anatomical Structure Morphogenesis Maintenance Of DNA Repeat Elements Positive Regulation Of Metabolic Process Organ Morphogenesis Response To Organic Substance Oxalate Transport	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signaling ERBB Signaling Pathway Regulation Of Signal Transduction Signaling Positive Regulation Of Signal Transduction Signal Transduction Cell Communication Cell Surface Receptor Signaling Pathway Response To Growth Factor Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Catalytic Activity Protein Autophosphorylation Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Response To Stimulus Cellular Response To Organonitrogen Compound Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Response To Organic Substance Phosphatidylinositol-mediated Signaling Regulation Of Immune Response Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Peptidyl-amino Acid Modification Immune Response-regulating Signaling Pathway Response To Fibroblast Growth Factor Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Response To Peptide Hormone Stimulus Regulation Of MAPK Cascade Immune System Process Positive Regulation Of Transferase Activity Phosphorylation Cellular Response To Peptide Positive Regulation Of MAPK Cascade Fc-epsilon Receptor Signaling Pathway Innate Immune Response
Tagcloud ?		abca1 adamtsl3 aiming apc crc elac1 epha3 ercc6 excluding exome fbxw7 germline kbiosciences marginal mll3 obscn pkhd1 recessive rs4987622 rs6464211 rs6947538 silico smad4 snps somatic spite strongest syne1 trpv6	abundantly adhesions arises associating carboxy cas conferring connect coordinating dim1p efs encompassed encompasses fyn hef1 identifies interactor localize multidomain oncoproteins p105 p115 p130 p55 sh3 sin spindle sum unexpectedly
Tagcloud (Difference) ?		abca1 adamtsl3 aiming apc crc elac1 epha3 ercc6 excluding exome fbxw7 germline kbiosciences marginal mll3 obscn pkhd1 recessive rs4987622 rs6464211 rs6947538 silico smad4 snps somatic spite strongest syne1 trpv6	abundantly adhesions arises associating carboxy cas conferring connect coordinating dim1p efs encompassed encompasses fyn hef1 identifies interactor localize multidomain oncoproteins p105 p115 p130 p55 sh3 sin spindle sum unexpectedly
Tagcloud (Intersection) ?