EPHB6 and DUSP18

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		EPHB6	DUSP18
Description		EPH receptor B6	dual specificity phosphatase 18
Image
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Membrane Dendrite	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Signaling Receptor Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Ephrin Receptor Signaling Pathway	Dephosphorylation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs		Fostamatinib
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Cancer ( 29299148)
Interacting Genes		28 interacting genes: AFDN ASB12 CBL CRK CRKL DDIT4L DUSP18 DUSP19 EFNB2 EPHB1 ERBB2 GRB2 HDHD2 INCA1 MSX2 MTARC1 NIF3L1 NOTCH2NLA POU6F2 PRMT5 REL SAT1 STYX TCF4 TEKT5 TRIB3 TRIM39 VPS26C	14 interacting genes: EPHA2 EPHA3 EPHA7 EPHB6 ERBB2 ERBB3 ERBB4 IGF1R INSR MAPK8IP2 PTK7 ROR1 ROR2 TEK
Entrez ID		2051	150290
HPRD ID		04133	13253
Ensembl ID		ENSG00000106123	ENSG00000167065
Uniprot IDs		A0A0G2JNH7 F8WCM8 O15197	F2Z2P2 Q8NEJ0
PDB IDs		7K7J	2ESB
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Regulation Of MAPK Cascade Phosphotyrosine Residue Binding Regulation Of Signal Transduction Receptor Tyrosine Kinase Binding Helper T Cell Diapedesis Cerebellar Neuron Development Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Enzyme-linked Receptor Protein Signaling Pathway Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Inhibitor Activity Cellular Response To Growth Factor Stimulus Ephrin Receptor Signaling Pathway Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Adhesion Postsynaptic Specialization Assembly Response To Growth Factor Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Positive Regulation Of Small GTPase Mediated Signal Transduction Neuromuscular Junction Cerebral Cortex Development Regulation Of Receptor Clustering Positive Regulation Of Rac Protein Signal Transduction Schwann Cell Development Protein Tyrosine/serine/threonine Phosphatase Activity Establishment Of Cell Polarity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Postsynaptic Specialization Organization SH3 Domain Binding Neuron Projection Development Regulation Of Protein Serine/threonine Kinase Activity Cytoplasm Signal Transduction Protein Binding Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Adhesion Regulation Of Rac Protein Signal Transduction T Cell Migration Identical Protein Binding Guanyl-nucleotide Exchange Factor Adaptor Activity Spermidine Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Kinase Activity ATP Binding Cell Surface Receptor Signaling Pathway Nucleotide Binding Regulation Of MAPK Cascade Ephrin Receptor Activity Transferase Activity Signal Transduction Positive Regulation Of MAPK Cascade Growth Factor Binding Ephrin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Coreceptor Activity Transmembrane-ephrin Receptor Activity Basal Plasma Membrane Regulation Of Intracellular Signal Transduction Plasma Membrane Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Projection Organization Neuron Projection Guidance Axon Guidance ERBB3:ERBB2 Complex Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction ERBB2 Signaling Pathway Regulation Of Signal Transduction Heart Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Neuregulin Receptor Activity Insulin Receptor Activity Regulation Of ERK1 And ERK2 Cascade Plasma Membrane Bounded Cell Projection Organization Insulin Receptor Complex Animal Organ Development Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Insulin Binding System Development
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