MAP4 and CLASP1

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		MAP4	CLASP1
Description		microtubule associated protein 4	cytoplasmic linker associated protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Axon Ciliary Basal Body Neuron Projection Mitotic Spindle	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Spindle Kinetochore Microtubule Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Focal Adhesion Cell Cortex Membrane Cortical Microtubule Cytoskeleton Centrosomal Corona Microtubule Plus-end Basal Cortex Mitotic Spindle
	Molecular Function	RNA Binding Structural Molecule Activity Protein Binding Microtubule Binding Tubulin Binding Microtubule Stabilizing Activity	Dystroglycan Binding Protein Binding Microtubule Binding Tubulin Binding Kinetochore Binding Microtubule Plus-end Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Neuron Projection Development Microtubule Polymerization Microtubule Sliding Establishment Of Spindle Orientation Cell Division Cilium Disassembly Negative Regulation Of Non-motile Cilium Assembly	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Vesicle Targeting Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Golgi Organization Mitotic Spindle Organization Establishment Or Maintenance Of Cell Polarity Exit From Mitosis Regulation Of Gastrulation Positive Regulation Of Epithelial Cell Migration Regulation Of Epithelial To Mesenchymal Transition Establishment Of Cell Polarity Astral Microtubule Organization Microtubule Organizing Center Organization Negative Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Microtubule Polymerization Microtubule Anchoring Establishment Of Mitotic Spindle Localization Positive Regulation Of Exocytosis Establishment Of Spindle Orientation Cell Division Negative Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Basement Membrane Organization Positive Regulation Of Extracellular Matrix Disassembly Mitotic Spindle Assembly Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Role of ABL in ROBO-SLIT signaling Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs		Paclitaxel Docetaxel Artenimol	Fostamatinib
Diseases
GWAS		Blood pressure ( 21909110) Body mass index and systole blood pressure (pairwise) ( 33619380) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 27618452 27841878 28739976) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean arterial pressure ( 27618448) Medication use (calcium channel blockers) ( 31015401) Pulse pressure ( 27841878) Systolic blood pressure ( 27618452 27841878 28739976 30578418)	Chloride levels ( 29403010) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 23823483) Potassium levels ( 29403010) Triglyceride levels ( 32154731)
Interacting Genes		26 interacting genes: CCNB1 CDC42 CDK1 CEBPA CLASP1 ENO2 ERBIN GSK3B IL7R LDLR MARK1 MARK4 NEIL3 NOP58 NR1I3 POT1 RNF10 RXRB RXRG SNTA1 SRPK2 STRBP SUMO2 TERF1 TUBB UBC	12 interacting genes: CEBPA CKAP5 EIF4ENIF1 JAKMIP2 MAP4 MAPRE1 MAPRE3 MARK3 MTNR1A MTNR1B SRPK2 YWHAG
Entrez ID		4134	23332
HPRD ID		01141	09322
Ensembl ID		ENSG00000047849	ENSG00000074054
Uniprot IDs		A0A804HKE7 E7EVA0 P27816	A0A8V8TLP7 A0A8V8TRF6 Q7Z460
PDB IDs			4K92 6MQ5 6MQ7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cyclin B1-CDK1 Complex Positive Regulation Of Organelle Organization Tau-protein Kinase Activity Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Organelle Organization Positive Regulation Of Metabolic Process Cytoskeleton Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Postsynapse Shelterin Complex Microtubule Cytoskeleton Organization Cell Division Positive Regulation Of Biosynthetic Process Tau Protein Binding Positive Regulation Of Protein Localization To Centrosome Retinoic Acid-responsive Element Binding Mitotic Spindle Mitotic Cell Cycle Phase Transition Cytoskeleton Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Activity Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Ventricular Cardiac Muscle Cell Development Cell Cycle Phase Transition Establishment Or Maintenance Of Cell Polarity G-rich Strand Telomeric DNA Binding Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Cilium Disassembly Telomeric Loop Disassembly Nucleoplasm Response To Lipid Microtubule-based Process Regulation Of Protein Localization To Centrosome Telomere Capping Protein Phosphorylation Glutamatergic Synapse Protein Serine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Protein Tag Activity Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Organelle Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Cell Cycle G1/S Phase Transition	Microtubule Binding Microtubule Polymerization Microtubule Plus-end Microtubule Plus-end Binding Mitotic Spindle Astral Microtubule End Microtubule Polymerization Or Depolymerization Melatonin Receptor Activity Spindle Organization Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Protein Polymerization Microtubule Cytoskeleton Microtubule Organizing Center Protein Localization To Microtubule Kinase Binding Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Cytoskeleton Organization Involved In Mitosis Protein Serine/threonine Kinase Binding Organelle Organization Spindle Midzone Microtubule-based Process Regulation Of Microtubule Cytoskeleton Organization Cell Division Positive Regulation Of Microtubule Polymerization RNA Binding Establishment Of Spindle Orientation Cytoskeleton Organization Protein Localization To Cytoskeleton RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Microtubule Plus End Polymerase Protein Localization To Astral Microtubule Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Establishment Of Spindle Localization Cellular Component Assembly Cytoplasmic Microtubule Regulation Of Microtubule-based Process Tubulin Binding Spindle Localization Protein Localization To Organelle Membraneless Organelle Assembly Response To Vitamin B2 C/EBP Complex Negative Regulation Of Non-motile Cilium Assembly Microtubule Stabilizing Activity Ciliary Basal Body Protein Localization To Mitotic Spindle Protein Localization To Spindle Microtubule Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Protein-containing Complex Assembly
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