MAP4 and NOP58

Number of citations: 38 (PubMedID 30217970)
Data Source: BioGRID (two hybrid)

		MAP4	NOP58
Name		microtubule associated protein 4	NOP58 ribonucleoprotein
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Axon Ciliary Basal Body Neuron Projection Mitotic Spindle	Fibrillar Center Nucleus Nucleoplasm Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cytosol Cajal Body Membrane Box C/D Methylation Guide SnoRNP Complex Small-subunit Processome Pre-snoRNP Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Structural Molecule Activity Protein Binding Microtubule Binding Tubulin Binding Microtubule Stabilizing Activity	TFIID-class Transcription Factor Complex Binding RNA Binding Protein Binding SnoRNA Binding ATPase Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Neuron Projection Development Microtubule Polymerization Microtubule Sliding Establishment Of Spindle Orientation Cell Division Cilium Disassembly Negative Regulation Of Non-motile Cilium Assembly	RRNA Processing Ribosome Biogenesis Ribosomal Small Subunit Biogenesis SnoRNA Localization
Pathways		None	SUMOylation of RNA binding proteins rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Paclitaxel Docetaxel Artenimol	None
GWAS		Blood pressure ( 21909110 ) Body mass index and systole blood pressure (pairwise) ( 33619380 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Diastolic blood pressure ( 27618452 27841878 28739976 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Mean arterial pressure ( 27618448 ) Medication use (calcium channel blockers) ( 31015401 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27618452 27841878 28739976 30578418 )	No GWAS studies recorded
Novel Interactors		None recorded	2 novel interactors: PPIL3 SF3B1
Interacting Genes		26 interacting genes: CCNB1 CDC42 CDK1 CEBPA CLASP1 ENO2 ERBIN GSK3B IL7R LDLR MARK1 MARK4 NEIL3 NOP58 NR1I3 POT1 RNF10 RXRB RXRG SNTA1 SRPK2 STRBP SUMO2 TERF1 TUBB UBC	8 interacting genes: ANXA1 CEBPA CSNK2A1 MAP4 OGT PTEN UBE2I WDR3
Entrez ID		4134	51602
HPRD ID		01141	11036
Ensembl ID		ENSG00000047849	ENSG00000055044
Uniprot IDs		A0A804HKE7 E7EVA0 P27816	Q9Y2X3
PDB IDs		Not available	7MQ8 7MQ9 7MQA
GO Terms Enriched among Interactors		Positive Regulation Of Macromolecule Metabolic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cyclin B1-CDK1 Complex Positive Regulation Of Organelle Organization Tau-protein Kinase Activity Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Organelle Organization Positive Regulation Of Metabolic Process Cytoskeleton Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Postsynapse Shelterin Complex Microtubule Cytoskeleton Organization Cell Division Positive Regulation Of Biosynthetic Process Tau Protein Binding Positive Regulation Of Protein Localization To Centrosome Retinoic Acid-responsive Element Binding Mitotic Spindle Mitotic Cell Cycle Phase Transition Cytoskeleton Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Activity Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Ventricular Cardiac Muscle Cell Development Cell Cycle Phase Transition Establishment Or Maintenance Of Cell Polarity G-rich Strand Telomeric DNA Binding Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Cilium Disassembly Telomeric Loop Disassembly Nucleoplasm Response To Lipid Microtubule-based Process Regulation Of Protein Localization To Centrosome Telomere Capping Protein Phosphorylation Glutamatergic Synapse Protein Serine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Protein Tag Activity Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Organelle Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Cell Cycle G1/S Phase Transition	Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm PML Body Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Sin3-type Complex Macromolecule Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cell Development RNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Rhythmic Process Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Membraneless Organelle Assembly Negative Regulation Of Synaptic Vesicle Clustering Membrane Assembly SUMO Conjugating Enzyme Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly U11/U12 SnRNP Lipid Binding Positive Regulation Of Protein Metabolic Process Chromatin DNA Binding Regulation Of Protein Catabolic Process Negative Regulation Of Cell Cycle Regulation Of Transcription By RNA Polymerase II Response To Vitamin B2 C/EBP Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Component Assembly Negative Regulation Of Non-motile Cilium Assembly Microtubule Stabilizing Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Catalytic Step 2 Spliceosome Organelle Organization Protein Localization To Vacuole Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Migration Negative Regulation Of Developmental Process CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Translational Initiation Protein Kinase CK2 Complex