MAP4 and MARK1

Number of citations of the paper that reports this interaction (PubMedID 8631898)
0

Data Source:
HPRD (in vitro)

		MAP4	MARK1
Description		microtubule associated protein 4	microtubule affinity regulating kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Axon Ciliary Basal Body Neuron Projection Mitotic Spindle	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Dendrite Cell Projection Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Binding Structural Molecule Activity Protein Binding Microtubule Binding Tubulin Binding Microtubule Stabilizing Activity	Nucleotide Binding Magnesium Ion Binding Phosphatidylserine Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Kinase Activity Transferase Activity Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Phosphatidic Acid Binding Protein Serine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Neuron Projection Development Microtubule Polymerization Microtubule Sliding Establishment Of Spindle Orientation Cell Division Cilium Disassembly Negative Regulation Of Non-motile Cilium Assembly	Microtubule Cytoskeleton Organization Neuron Migration Protein Phosphorylation Cytoskeleton Organization Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Wnt Signaling Pathway Intracellular Signal Transduction Regulation Of Dendrite Development Establishment Of Mitochondrion Localization Regulation Of Postsynapse Assembly
Pathways
Drugs		Paclitaxel Docetaxel Artenimol	Fostamatinib
Diseases
GWAS		Blood pressure ( 21909110) Body mass index and systole blood pressure (pairwise) ( 33619380) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 27618452 27841878 28739976) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean arterial pressure ( 27618448) Medication use (calcium channel blockers) ( 31015401) Pulse pressure ( 27841878) Systolic blood pressure ( 27618452 27841878 28739976 30578418)	Bipolar disorder ( 22205951) Breast size ( 27182965) Fat distribution (HIV) ( 21897333)
Interacting Genes		26 interacting genes: CCNB1 CDC42 CDK1 CEBPA CLASP1 ENO2 ERBIN GSK3B IL7R LDLR MARK1 MARK4 NEIL3 NOP58 NR1I3 POT1 RNF10 RXRB RXRG SNTA1 SRPK2 STRBP SUMO2 TERF1 TUBB UBC	11 interacting genes: CCDC102B GJA5 INCA1 MAP2 MAP4 MAPT STK11 TAOK1 TCL1B TFAP2A YAF2
Entrez ID		4134	4139
HPRD ID		01141	07353
Ensembl ID		ENSG00000047849	ENSG00000116141
Uniprot IDs		A0A804HKE7 E7EVA0 P27816	A0A087X0I6 B4DIB3 Q9P0L2 X5D2M4
PDB IDs			2HAK 3OSE 6C9D
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cyclin B1-CDK1 Complex Positive Regulation Of Organelle Organization Tau-protein Kinase Activity Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Organelle Organization Positive Regulation Of Metabolic Process Cytoskeleton Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Postsynapse Shelterin Complex Microtubule Cytoskeleton Organization Cell Division Positive Regulation Of Biosynthetic Process Tau Protein Binding Positive Regulation Of Protein Localization To Centrosome Retinoic Acid-responsive Element Binding Mitotic Spindle Mitotic Cell Cycle Phase Transition Cytoskeleton Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Activity Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Ventricular Cardiac Muscle Cell Development Cell Cycle Phase Transition Establishment Or Maintenance Of Cell Polarity G-rich Strand Telomeric DNA Binding Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Cilium Disassembly Telomeric Loop Disassembly Nucleoplasm Response To Lipid Microtubule-based Process Regulation Of Protein Localization To Centrosome Telomere Capping Protein Phosphorylation Glutamatergic Synapse Protein Serine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Protein Tag Activity Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Organelle Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Cell Cycle G1/S Phase Transition	Regulation Of Microtubule-based Process Positive Regulation Of Vesicle Transport Along Microtubule Main Axon Central Nervous System Neuron Development Regulation Of Microtubule-based Movement Neuronal Cell Body Neuron Development Tubulin Binding Regulation Of Organelle Transport Along Microtubule Negative Regulation Of Growth Embryonic Limb Morphogenesis Atrial Septum Morphogenesis Limb Morphogenesis Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Stress-activated MAPK Cascade Generation Of Neurons Microtubule Polymerization Negative Regulation Of Developmental Process Regulation Of Growth Regulation Of Axonogenesis Isotype Switching To IgA Isotypes DN3 Thymocyte Differentiation Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Mitral Valve Development Septum Primum Development Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Atrial Ventricular Junction Remodeling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Ventricular Septum Morphogenesis Positive Regulation Of Cell Communication By Chemical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling Skeletal System Development Vasomotion Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Purkinje Myocyte Action Potential Negative Regulation Of Cell Population Proliferation Axon Negative Regulation Of Cell Growth Regulation Of Cell Growth Regulation Of Microtubule Cytoskeleton Organization Microtubule Cytoskeleton Organization Apical Distal Dendrite Negative Regulation Of Microtubule Polymerization Or Depolymerization Tau Protein Binding Microtubule Associated Complex Microtubule Polymerization Or Depolymerization Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Optic Cup Structural Organization
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