EMP3 and P2RX7

Number of citations of the paper that reports this interaction (PMID 12107182)
25

Data Source:
HPRD (in vitro)

		EMP3	P2RX7
Gene Name		epithelial membrane protein 3	purinergic receptor P2X, ligand gated ion channel, 7
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Integral Component Of Nuclear Inner Membrane Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane Neuromuscular Junction Bleb Neuronal Cell Body Terminal Bouton Protein Complex Membrane Raft
	Molecular Function	Protein Binding	Magnesium Ion Binding Lipopolysaccharide Binding Purinergic Nucleotide Receptor Activity Extracellular ATP-gated Cation Channel Activity Receptor Binding Copper Ion Binding Protein Binding ATP Binding Zinc Ion Binding Protein Homodimerization Activity Scaffold Protein Binding
	Biological Process	Cell Death Negative Regulation Of Cell Proliferation Cell Growth Bleb Assembly	Activation Of MAPK Activity Cell Morphogenesis Phagolysosome Assembly Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Sodium Ion Transport Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Phospholipid Transfer To Membrane Cell Volume Homeostasis Membrane Budding Inflammatory Response Mitochondrion Organization Plasma Membrane Organization Cell Surface Receptor Signaling Pathway Response To Mechanical Stimulus Response To Zinc Ion Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Synaptic Vesicle Exocytosis Protein Processing Neuronal Action Potential Sensory Perception Of Pain Cytolysis Positive Regulation Of Bone Mineralization Cellular Response To Extracellular Stimulus Bleb Assembly Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Collagen Metabolic Process Response To ATP Response To Fluid Shear Stress Purinergic Nucleotide Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway T Cell Proliferation Response To Drug T Cell Homeostasis NAD Transport Negative Regulation Of MAPK Cascade Multicellular Organismal Protein Catabolic Process Innate Immune Response Phospholipid Translocation Negative Regulation Of Bone Resorption Positive Regulation Of Cytolysis Ceramide Biosynthetic Process Pore Complex Assembly Skeletal System Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Interleukin-1 Beta Secretion Defense Response To Gram-positive Bacterium Release Of Sequestered Calcium Ion Into Cytosol Protein Oligomerization Positive Regulation Of Cytoskeleton Organization Response To Calcium Ion Response To Electrical Stimulus Regulation Of Killing Of Cells Of Other Organism Membrane Depolarization Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Lymphocyte Apoptotic Process Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cation Transmembrane Transport
Pathways			The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS			Chronic obstructive pulmonary disease-related biomarkers ( 23144326)
Protein-Protein Interactions		3 interactors: CREM EDA P2RX7	9 interactors: ACTB CASK EFNB3 EMP3 KRT31 KRTAP10-8 PANX1 SVIL TM9SF1
Entrez ID		2014	5027
HPRD ID		18514	03977
Ensembl ID		ENSG00000142227	ENSG00000089041
Uniprot IDs		P54852	Q99572
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Organophosphorus Sphingolipid Metabolic Process Response To Purine-containing Compound Phospholipid Transfer To Membrane NAD Transport Membrane Lipid Metabolic Process Positive Regulation Of Intracellular Transport Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Cytolysis Trachea Gland Development Multicellular Organismal Protein Catabolic Process Positive Regulation Of Glutamate Secretion Multicellular Organismal Protein Metabolic Process Positive Regulation Of Protein Transport Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Gamma-aminobutyric Acid Secretion Salivary Gland Cavitation Regulation Of Intracellular Transport Regulation Of Killing Of Cells Of Other Organism Bleb Assembly Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Amino Acid Transport Pore Complex Assembly Negative Regulation Of Bone Resorption Regulation Of Glutamate Secretion Phagolysosome Assembly Negative Regulation Of Bone Remodeling Positive Regulation Of Prostaglandin Secretion Regulation Of Protein Transport Negative Regulation Of Tissue Remodeling Hair Follicle Placode Formation Regulation Of Mitochondrial Depolarization Membrane Protein Ectodomain Proteolysis Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Establishment Of Protein Localization Positive Regulation Of Icosanoid Secretion Positive Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Interleukin-1 Secretion Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Transport Regulation Of Interleukin-1 Beta Secretion Ectoderm Development Cytolysis Positive Regulation Of Fatty Acid Transport Regulation Of Protein Localization Response To ATP Positive Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Positive Regulation Of Interleukin-1 Beta Production Trachea Development
Tagcloud ?		19q13 adhesion bioinformatics cavities crosstalk designing erbb2 estimates guided immunoblot indicator innovative integrins kaplan log meier neoplastic oncogene pyelocalyceal rank selecting stratification tract transcriptase upper ureter urinary urothelial validate	adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss parsimony prkd1 ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22
Tagcloud (Difference) ?		19q13 adhesion bioinformatics cavities crosstalk designing erbb2 estimates guided immunoblot indicator innovative integrins kaplan log meier neoplastic oncogene pyelocalyceal rank selecting stratification tract transcriptase upper ureter urinary urothelial validate	adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss parsimony prkd1 ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22
Tagcloud (Intersection) ?