EMP3 and EDA

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EMP3	EDA
Gene Name		epithelial membrane protein 3	ectodysplasin A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region Collagen Trimer Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Apical Part Of Cell
	Molecular Function	Protein Binding	Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Cell Death Negative Regulation Of Cell Proliferation Cell Growth Bleb Assembly	Immune Response Cell-matrix Adhesion Signal Transduction Ectoderm Development Gene Expression Cell Differentiation Positive Regulation Of NF-kappaB Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Pigmentation Positive Regulation Of NF-kappaB Transcription Factor Activity Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514)
Protein-Protein Interactions		3 interactors: CREM EDA P2RX7	15 interactors: ATP6V0C CYB561 DOLK EDA2R EDAR EMP3 FURIN GIMAP5 LEPROTL1 MAL NIPAL3 OSTC OSTCP1 PLN SEC22A
Entrez ID		2014	1896
HPRD ID		18514	02347
Ensembl ID		ENSG00000142227	ENSG00000158813
Uniprot IDs		P54852	Q92838
PDB IDs			1RJ7 1RJ8
Enriched GO Terms of Interacting Partners?		Response To Organophosphorus Sphingolipid Metabolic Process Response To Purine-containing Compound Phospholipid Transfer To Membrane NAD Transport Membrane Lipid Metabolic Process Positive Regulation Of Intracellular Transport Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Cytolysis Trachea Gland Development Multicellular Organismal Protein Catabolic Process Positive Regulation Of Glutamate Secretion Multicellular Organismal Protein Metabolic Process Positive Regulation Of Protein Transport Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Gamma-aminobutyric Acid Secretion Salivary Gland Cavitation Regulation Of Intracellular Transport Regulation Of Killing Of Cells Of Other Organism Bleb Assembly Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Amino Acid Transport Pore Complex Assembly Negative Regulation Of Bone Resorption Regulation Of Glutamate Secretion Phagolysosome Assembly Negative Regulation Of Bone Remodeling Positive Regulation Of Prostaglandin Secretion Regulation Of Protein Transport Negative Regulation Of Tissue Remodeling Hair Follicle Placode Formation Regulation Of Mitochondrial Depolarization Membrane Protein Ectodomain Proteolysis Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Establishment Of Protein Localization Positive Regulation Of Icosanoid Secretion Positive Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Interleukin-1 Secretion Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Transport Regulation Of Interleukin-1 Beta Secretion Ectoderm Development Cytolysis Positive Regulation Of Fatty Acid Transport Regulation Of Protein Localization Response To ATP Positive Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Positive Regulation Of Interleukin-1 Beta Production Trachea Development	Positive Regulation Of Interleukin-15 Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Cytotoxic T Cell Differentiation Negative Regulation Of Calcium-transporting ATPase Activity TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Dolichyl Monophosphate Biosynthetic Process Negative Regulation Of Hydrolase Activity Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Nerve Growth Factor Production Negative Regulation Of Calcium Ion Binding Regulation Of The Force Of Heart Contraction By Cardiac Conduction Protein N-linked Glycosylation Via Asparagine Cell Death Death Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta1 Production Membrane Raft Polarization Regulation Of Calcium-transporting ATPase Activity Negative Regulation Of Receptor Catabolic Process Adrenergic Receptor Signaling Pathway Involved In Heart Process Protein N-linked Glycosylation Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Nerve Growth Factor Processing G-protein Coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Membrane Raft Localization Dolichyl Diphosphate Biosynthetic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Calcium Ion Import Negative Regulation Of Transforming Growth Factor Beta Production Ectodermal Cell Differentiation Regulation Of JNK Cascade Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Relaxation Of Cardiac Muscle Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Salivary Gland Cavitation Regulation Of Stress-activated MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of ATPase Activity Regulation Of Relaxation Of Muscle Vesicle Fusion With Golgi Apparatus Regulation Of Cardiac Muscle Cell Membrane Potential Post-translational Protein Modification Transport
Tagcloud ?		19q13 adhesion bioinformatics cavities crosstalk designing erbb2 estimates guided immunoblot indicator innovative integrins kaplan log meier neoplastic oncogene pyelocalyceal rank selecting stratification tract transcriptase upper ureter urinary urothelial validate	amplitudes asymmetry atypical comparison conductance contralateral depend discrepancy disinhibition electrodermal former frontal hemisphere idea left lesion motor neurophysiological phasic rejected right scl scls seem showing sweating tonic unrelated weakness
Tagcloud (Difference) ?		19q13 adhesion bioinformatics cavities crosstalk designing erbb2 estimates guided immunoblot indicator innovative integrins kaplan log meier neoplastic oncogene pyelocalyceal rank selecting stratification tract transcriptase upper ureter urinary urothelial validate	amplitudes asymmetry atypical comparison conductance contralateral depend discrepancy disinhibition electrodermal former frontal hemisphere idea left lesion motor neurophysiological phasic rejected right scl scls seem showing sweating tonic unrelated weakness
Tagcloud (Intersection) ?