ELAVL1 and XIAP

Number of citations of the paper that reports this interaction (PMID 21102524)
14

Data Source:
BioGRID (unspecified method)

		ELAVL1	XIAP
Gene Name		ELAV like RNA binding protein 1	X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule
	Molecular Function	Nucleotide Binding RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding AU-rich Element Binding Protein Kinase Binding MRNA 3'-UTR AU-rich Region Binding Poly(A) RNA Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Multicellular Organismal Development Gene Expression Positive Regulation Of Translation MRNA Stabilization 3'-UTR-mediated MRNA Stabilization Regulation Of Stem Cell Maintenance	Apoptotic Process Cellular Response To DNA Damage Stimulus Wnt Signaling Pathway Protein Ubiquitination Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Innate Immune Response Regulation Of Inflammatory Response Copper Ion Homeostasis Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Mitotic Spindle Assembly Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Linear Polyubiquitination Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements HuR stabilizes mRNA	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling SMAC binds to IAPs SMAC-mediated dissociation of IAP:caspase complexes SMAC-mediated apoptotic response Signaling by Wnt deactivation of the beta-catenin transactivating complex Apoptotic factor-mediated response TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Programmed Cell Death XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Intrinsic Pathway for Apoptosis
Drugs			1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
Diseases
GWAS
Protein-Protein Interactions		35 interactors: ANP32A ANP32B APOE CARM1 CELF2 CHEK2 CTNNB1 ERG GJB3 HNRNPK HOTAIR IL7R KPNA1 KPNB1 MIRLET7B MIRLET7I NOS3 PAIP2 PLAU PLAUR PRKCA PRKCD PRKCE PSEN2 PTBP1 PTBP2 PTGS2 RBFOX2 SDCBP SET SREK1 TNPO1 TNPO2 VEGFA XIAP	67 interactors: ACVRL1 AFP AIFM1 AKT1 AKT2 BIRC5 BRCA1 CASP10 CASP3 CASP7 CASP9 CHEK1 CKS1B COMMD1 DIABLO DTX3 DYNLL2 ELAVL1 ERCC3 GSPT1 HTRA1 HTRA2 IKBKE INPP5D LONRF1 MAGED1 MAP3K2 MAP3K3 MAP3K7 NEK6 NOD1 NOD2 NOTCH1 RAF1 RFC5 RIPK1 RIPK2 RIPK3 RIPK4 SEPT4 SSX2IP STRADB STUB1 TAB1 TAB2 TBK1 TGFBR1 TRAF6 TRIM32 TRIM8 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2I UBE2J2 UBE2N UBE2V1 UBE2V2 UBE2W VPS37C WDYHV1 XAF1
Entrez ID		1994	331
HPRD ID		16025	02094
Ensembl ID		ENSG00000066044	ENSG00000101966
Uniprot IDs		B4DVB8 Q15717	B2R9R2 P98170
PDB IDs		3HI9 4ED5 4EGL 4FXV	1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48
Enriched GO Terms of Interacting Partners?		Regulation Of Wound Healing Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Positive Regulation Of Transport Negative Regulation Of Wound Healing Apoptotic Process Regulation Of Protein Metabolic Process Programmed Cell Death Negative Regulation Of Cellular Protein Metabolic Process Cell Death Death Regulation Of Platelet Activation Regulation Of Metabolic Process Cell Communication Signal Transduction Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Ion Transport Regulation Of Nitrogen Compound Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Receptor Activity Signaling Response To Abiotic Stimulus Blood Coagulation Negative Regulation Of Platelet Activation Hemostasis Regulation Of Epithelial Cell Migration Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To Stimulus Regulation Of Apoptotic Process Regulation Of Cell Proliferation Response To External Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Organic Substance Regulation Of Cell Death Response To Wounding Blood Circulation Response To Cytokine Execution Phase Of Apoptosis Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Epithelial Cell Migration Vasculature Development RNA Splicing Regulation Of Peptidyl-tyrosine Phosphorylation	Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Apoptotic Process Activation Of Innate Immune Response Programmed Cell Death Cell Death Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Stress Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Stress Positive Regulation Of Protein Modification Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Protein Metabolic Process Protein Polyubiquitination Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Transferase Activity Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signal Transduction By Phosphorylation Innate Immune Response Regulation Of Signal Transduction Cellular Protein Modification Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Metabolic Process Protein Ubiquitination Regulation Of Apoptotic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Catalytic Activity Regulation Of Cell Death Apoptotic Signaling Pathway Regulation Of Signaling Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Apoptotic Process
Tagcloud ?		bace1 bingo cdk2 clustering criterion cytoscape degs downloaded glioma gse31262 hierarchical kif23 kobas language limma log2fc mbp multtest myelination omnibus ontology package pheatmap plp1 plug software string webgestalt wee1	anthracyclines antiapoptotic apaf bcp carbinol childhood coadministration cruciferous cure doxorubicin dramatic evidenced i3c iap1 indole innovative lymphoblastic modality nalm nontoxic noxa opportunities parp phytochemical potentiates puma topoisomerase vegetables xl
Tagcloud (Difference) ?		bace1 bingo cdk2 clustering criterion cytoscape degs downloaded glioma gse31262 hierarchical kif23 kobas language limma log2fc mbp multtest myelination omnibus ontology package pheatmap plp1 plug software string webgestalt wee1	anthracyclines antiapoptotic apaf bcp carbinol childhood coadministration cruciferous cure doxorubicin dramatic evidenced i3c iap1 indole innovative lymphoblastic modality nalm nontoxic noxa opportunities parp phytochemical potentiates puma topoisomerase vegetables xl
Tagcloud (Intersection) ?