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XIAP and ERCC3
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
XIAP
ERCC3
Description
X-linked inhibitor of apoptosis
ERCC excision repair 3, TFIIH core complex helicase subunit
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleotide-excision Repair Factor 3 Complex
Transcription Factor TFIIH Core Complex
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIH Holo Complex
Transcription Preinitiation Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Peptidase Inhibitor Activity
Identical Protein Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Protein Serine/threonine Kinase Binding
Nucleotide Binding
DNA Binding
DNA Helicase Activity
Damaged DNA Binding
Helicase Activity
Protein Binding
ATP Binding
Hydrolase Activity
Isomerase Activity
ATP Hydrolysis Activity
3'-5' DNA Helicase Activity
Promoter-specific Chromatin Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
DNA Damage Response
Canonical NF-kappaB Signal Transduction
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Wnt Signaling Pathway
Regulation Of BMP Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
P38MAPK Cascade
Defense Response To Bacterium
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Innate Immune Response
Positive Regulation Of JNK Cascade
Regulation Of Inflammatory Response
Neuron Apoptotic Process
Regulation Of Cell Cycle
Copper Ion Homeostasis
Regulation Of Apoptosis Involved In Tissue Homeostasis
Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Protein K63-linked Ubiquitination
Positive Regulation Of Canonical Wnt Signaling Pathway
Protein Linear Polyubiquitination
Execution Phase Of Apoptosis
Positive Regulation Of Protein Linear Polyubiquitination
DNA Topological Change
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Transcription By RNA Polymerase II
Transcription Initiation At RNA Polymerase II Promoter
Transcription Elongation By RNA Polymerase II
Apoptotic Process
DNA Damage Response
Response To Oxidative Stress
Intracellular Protein Localization
Response To UV
UV Protection
Hair Cell Differentiation
Positive Regulation Of Apoptotic Process
Embryonic Organ Development
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC, XIAP-regulated apoptotic response
Deactivation of the beta-catenin transactivating complex
RIPK1-mediated regulated necrosis
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Regulation of necroptotic cell death
Regulation of PTEN localization
Regulation of PTEN stability and activity
Regulation of the apoptosome activity
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Drugs
1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide
Dequalinium
N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
AEG35156
Terpinen-4-ol
Diseases
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Interacting Genes
105 interacting genes:
ACVRL1
AFP
AIFM1
AKT1
AKT2
BCL2
BIRC5
BOLA1
BOLA2
BOLA2B
BRCA1
CAD
CASP10
CASP3
CASP7
CASP9
CCNB1
CDC42
CDK1
CHEK1
CKS1B
COMMD1
DIABLO
DNM2
DTX3
DYNLL2
EEF2
ERCC3
FAF1
FLNA
FLNB
GCC1
GOLGA2
GSK3B
GSPT1
HNRNPA1
HSP90AB1
HSPA1A
HTRA1
HTRA2
HTRA3
IKBKE
INPP5D
KCNJ6
LIMA1
LONRF1
MAGED1
MAP3K2
MAP3K3
MAP3K7
MCRS1
MDM2
NCOA6
NEK6
NOD1
NOD2
NOTCH1
NTAQ1
OGT
PGAM5
PIBF1
PPIH
PPM1K
QARS1
RAF1
RFC5
RIPK3
RIPK4
RPS9
RUNX1T1
SDHA
SEPTIN4
SERPINA12
SERTAD1
SSX2IP
STRADB
STUB1
SYNE1
TAB1
TAB2
TBK1
TGFBR1
TPM3
TRAF6
TRIM32
TRIM8
TTC23
TUFM
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2I
UBE2J2
UBE2L3
UBE2N
UBE2V1
UBE2V2
UBE2W
VPS37C
XAF1
38 interacting genes:
ADAMTSL4
AR
BCR
BLZF1
CCNC
CCNH
CDC42
CDK7
CDK8
CEP70
CEP76
E2F1
ERCC2
GOLGA2
GTF2E1
GTF2E2
GTF2H1
GTF2H2
GTF2H3
GTF2H4
GTF2H5
KPNA3
MAGED1
MCF2
MNAT1
MSANTD2
PSMC5
RAD52
ROPN1
SNW1
SRPK2
TP53
TRIM14
TRIM27
TUBG1
XIAP
XPC
ZSCAN1
Entrez ID
331
2071
HPRD ID
02094
00593
Ensembl ID
ENSG00000101966
ENSG00000163161
Uniprot IDs
B2R9R2
P98170
B3KRG2
B3KTH1
P19447
PDB IDs
1C9Q
1F9X
1G3F
1G73
1I3O
1I4O
1I51
1KMC
1NW9
1TFQ
1TFT
2ECG
2JK7
2KNA
2OPY
2OPZ
2POI
2POP
2QRA
2VSL
3CLX
3CM2
3CM7
3EYL
3G76
3HL5
3UW4
3UW5
4EC4
4HY0
4IC2
4IC3
4J3Y
4J44
4J45
4J46
4J47
4J48
4KJU
4KJV
4KMP
4MTZ
4OXC
4WVS
4WVT
4WVU
5C0K
5C0L
5C3H
5C3K
5C7A
5C7B
5C7C
5C7D
5C83
5C84
5M6E
5M6F
5M6H
5M6L
5M6M
5O6T
5OQW
6EY2
6GJW
6QCI
8AZA
8GH7
8W59
8W5A
4ERN
5IVW
5IY6
5IY7
5IY8
5IY9
5OF4
6NMI
6O9L
6O9M
6RO4
7AD8
7EGB
7EGC
7ENA
7ENC
7LBM
7NVR
7NVV
7NVW
7NVX
7NVY
7NVZ
7NW0
8BVW
8BYQ
8EBS
8EBT
8EBU
8EBV
8EBW
8EBX
8EBY
8GXQ
8GXS
8WAK
8WAL
8WAN
8WAO
8WAP
8WAQ
8WAR
8WAS
Enriched GO Terms of Interacting Partners
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Protein Metabolic Process
Protein Modification Process
Protein Polyubiquitination
Cytosol
Macromolecule Metabolic Process
Regulation Of Intracellular Signal Transduction
Ubiquitin Conjugating Enzyme Activity
Regulation Of Signal Transduction
Nucleotide Binding
Programmed Cell Death
Cell Death
Regulation Of Protein Ubiquitination
Regulation Of Programmed Cell Death
Positive Regulation Of Protein Metabolic Process
Regulation Of Apoptotic Process
Post-translational Protein Modification
ATP Binding
Protein Ubiquitination
Ubiquitin Protein Ligase Binding
Cytoplasm
Regulation Of Signaling
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Cell Communication
Protein Modification By Small Protein Conjugation
Apoptotic Process
Regulation Of Protein Modification Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Protein Modification Process
Regulation Of Post-translational Protein Modification
Cellular Response To Stress
Positive Regulation Of Signal Transduction
Protein K63-linked Ubiquitination
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Apoptotic Process
Intracellular Signal Transduction
Regulation Of Protein Metabolic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Protein Ubiquitination
Protein-containing Complex
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Protein Binding
Transferase Activity
Positive Regulation Of Post-translational Protein Modification
Modification-dependent Protein Catabolic Process
Proteolysis
Macromolecule Catabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Signal Transduction
Regulation Of Apoptotic Signaling Pathway
Transcription Factor TFIIH Core Complex
Transcription Factor TFIIH Holo Complex
Transcription Initiation At RNA Polymerase II Promoter
Nucleotide-excision Repair
DNA-templated Transcription Initiation
Transcription Factor TFIID Complex
DNA-templated Transcription
CAK-ERCC2 Complex
RNA Polymerase II General Transcription Initiation Factor Activity
DNA Damage Response
Transcription By RNA Polymerase II
Nucleobase-containing Compound Biosynthetic Process
Transcription Factor TFIIK Complex
DNA Repair
Core TFIIH Complex Portion Of Holo TFIIH Complex
RNA Metabolic Process
Nucleoplasm
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleic Acid Metabolic Process
Nucleus
Regulation Of Cell Cycle
DNA Metabolic Process
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Cellular Response To Stress
Transcription Factor TFIIE Complex
Regulation Of Nucleobase-containing Compound Metabolic Process
Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Protein-containing Complex
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
CKM Complex
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Signal Transduction By P53 Class Mediator
Positive Regulation Of Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Transcription Elongation By RNA Polymerase I
Regulation Of Macromolecule Biosynthetic Process
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