XIAP and AIFM1

Number of citations of the paper that reports this interaction (PubMedID 22103349)
74

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		XIAP	AIFM1
Description		X-linked inhibitor of apoptosis	apoptosis inducing factor mitochondria associated 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Zinc Ion Binding Transferase Activity Peptidase Inhibitor Activity Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Ubiquitin Protein Ligase Activity Protein Serine/threonine Kinase Binding	DNA Binding NADH Dehydrogenase Activity Protein Binding NAD(P)H Oxidase H2O2-forming Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H Protein Dimerization Activity FAD Binding Poly-ADP-D-ribose Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process DNA Damage Response Canonical NF-kappaB Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Ubiquitination Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide P38MAPK Cascade Defense Response To Bacterium Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Regulation Of Inflammatory Response Neuron Apoptotic Process Regulation Of Cell Cycle Copper Ion Homeostasis Regulation Of Apoptosis Involved In Tissue Homeostasis Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Protein Linear Polyubiquitination Execution Phase Of Apoptosis Positive Regulation Of Protein Linear Polyubiquitination	Response To Ischemia Apoptotic Process Response To Toxic Substance Neuron Differentiation Mitochondrial Respiratory Chain Complex Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Protein Import Into Mitochondrial Intermembrane Space Positive Regulation Of Necroptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Nitric Oxide Mitochondrial Disulfide Relay System Response To L-glutamate Cellular Response To Aldosterone
Pathways		Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Deactivation of the beta-catenin transactivating complex RIPK1-mediated regulated necrosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Regulation of necroptotic cell death Regulation of PTEN localization Regulation of PTEN stability and activity Regulation of the apoptosome activity
Drugs		1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide Dequalinium N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE AEG35156 Terpinen-4-ol	Flavin adenine dinucleotide MCC
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)	Combined oxidative phosphorylation deficiency (COXPD)
GWAS			Bipolar disorder ( 31043756)
Interacting Genes		105 interacting genes: ACVRL1 AFP AIFM1 AKT1 AKT2 BCL2 BIRC5 BOLA1 BOLA2 BOLA2B BRCA1 CAD CASP10 CASP3 CASP7 CASP9 CCNB1 CDC42 CDK1 CHEK1 CKS1B COMMD1 DIABLO DNM2 DTX3 DYNLL2 EEF2 ERCC3 FAF1 FLNA FLNB GCC1 GOLGA2 GSK3B GSPT1 HNRNPA1 HSP90AB1 HSPA1A HTRA1 HTRA2 HTRA3 IKBKE INPP5D KCNJ6 LIMA1 LONRF1 MAGED1 MAP3K2 MAP3K3 MAP3K7 MCRS1 MDM2 NCOA6 NEK6 NOD1 NOD2 NOTCH1 NTAQ1 OGT PGAM5 PIBF1 PPIH PPM1K QARS1 RAF1 RFC5 RIPK3 RIPK4 RPS9 RUNX1T1 SDHA SEPTIN4 SERPINA12 SERTAD1 SSX2IP STRADB STUB1 SYNE1 TAB1 TAB2 TBK1 TGFBR1 TPM3 TRAF6 TRIM32 TRIM8 TTC23 TUFM UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2I UBE2J2 UBE2L3 UBE2N UBE2V1 UBE2V2 UBE2W VPS37C XAF1	11 interacting genes: CASP3 EIF3G HSPA1A HSPA1B MLH1 NOA1 SETDB1 STC2 TSC22D4 WWC1 XIAP
Entrez ID		331	9131
HPRD ID		02094	02161
Ensembl ID		ENSG00000101966	ENSG00000156709
Uniprot IDs		B2R9R2 P98170	E9PMA0 O95831
PDB IDs		1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48 4KJU 4KJV 4KMP 4MTZ 4OXC 4WVS 4WVT 4WVU 5C0K 5C0L 5C3H 5C3K 5C7A 5C7B 5C7C 5C7D 5C83 5C84 5M6E 5M6F 5M6H 5M6L 5M6M 5O6T 5OQW 6EY2 6GJW 6QCI 8AZA 8GH7 8W59 8W5A	1M6I 4BUR 4BV6 4FDC 4LII 5FMH 5FS6 5FS7 5FS8 5FS9 5KVH 5KVI 8D3E 8D3G 8D3H 8D3I 8D3J 8D3K 8D3N 8D3O 8VGY
Enriched GO Terms of Interacting Partners?		Protein Metabolic Process Protein Modification Process Protein Polyubiquitination Cytosol Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Ubiquitin Conjugating Enzyme Activity Regulation Of Signal Transduction Nucleotide Binding Programmed Cell Death Cell Death Regulation Of Protein Ubiquitination Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Post-translational Protein Modification ATP Binding Protein Ubiquitination Ubiquitin Protein Ligase Binding Cytoplasm Regulation Of Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cell Communication Protein Modification By Small Protein Conjugation Apoptotic Process Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Cellular Response To Stress Positive Regulation Of Signal Transduction Protein K63-linked Ubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Protein-containing Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Binding Transferase Activity Positive Regulation Of Post-translational Protein Modification Modification-dependent Protein Catabolic Process Proteolysis Macromolecule Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway	Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Negative Regulation Of Metabolic Process Negative Regulation Of Growth Positive Regulation Of Microtubule Nucleation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Inclusion Body Assembly Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Inclusion Body Perinuclear Region Of Cytoplasm Regulation Of Microtubule Nucleation Response To Oxidative Stress MRNA Catabolic Process Regulation Of Inclusion Body Assembly Regulation Of Mitotic Spindle Assembly Response To Lipid Execution Phase Of Apoptosis Enzyme Binding Protein Refolding Positive Regulation Of Defense Response Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Erythrocyte Differentiation Aggresome Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand ATP-dependent Protein Folding Chaperone Positive Regulation Of Microtubule Polymerization Regulation Of Spindle Assembly Regulation Of Protein Ubiquitination RNA Catabolic Process Cellular Response To Stress Regulation Of Mitotic Spindle Organization Response To Steroid Hormone Macromolecule Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Erythrocyte Differentiation Regulation Of Post-translational Protein Modification Cellular Response To Heat Regulation Of Growth Intracellular Signal Transduction Response To Hormone Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment
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