XIAP and UBE2V2

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		XIAP	UBE2V2
Gene Name		X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase	ubiquitin-conjugating enzyme E2 variant 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule	Nucleus Cytoplasm UBC13-MMS2 Complex Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Apoptotic Process Cellular Response To DNA Damage Stimulus Wnt Signaling Pathway Protein Ubiquitination Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Innate Immune Response Regulation Of Inflammatory Response Copper Ion Homeostasis Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Mitotic Spindle Assembly Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Linear Polyubiquitination Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Protein Polyubiquitination DNA Double-strand Break Processing Regulation Of DNA Repair Postreplication Repair Cell Proliferation Positive Regulation Of Neuron Projection Development Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA Repair Positive Regulation Of Synapse Assembly Protein K63-linked Ubiquitination
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling SMAC binds to IAPs SMAC-mediated dissociation of IAP:caspase complexes SMAC-mediated apoptotic response Signaling by Wnt deactivation of the beta-catenin transactivating complex Apoptotic factor-mediated response TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Programmed Cell Death XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Intrinsic Pathway for Apoptosis	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs		1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
Diseases
GWAS
Protein-Protein Interactions		67 interactors: ACVRL1 AFP AIFM1 AKT1 AKT2 BIRC5 BRCA1 CASP10 CASP3 CASP7 CASP9 CHEK1 CKS1B COMMD1 DIABLO DTX3 DYNLL2 ELAVL1 ERCC3 GSPT1 HTRA1 HTRA2 IKBKE INPP5D LONRF1 MAGED1 MAP3K2 MAP3K3 MAP3K7 NEK6 NOD1 NOD2 NOTCH1 RAF1 RFC5 RIPK1 RIPK2 RIPK3 RIPK4 SEPT4 SSX2IP STRADB STUB1 TAB1 TAB2 TBK1 TGFBR1 TRAF6 TRIM32 TRIM8 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2I UBE2J2 UBE2N UBE2V1 UBE2V2 UBE2W VPS37C WDYHV1 XAF1	22 interactors: BCL10 DZIP3 EGFR HLTF IGSF21 LRIF1 MALT1 MKRN3 MOB4 OTUB1 RNF144A RNF2 RNF8 SHPRH SIAH1 SUV39H2 TRAF2 TRIM5 UBC UBE2N XIAP ZNRF1
Entrez ID		331	7336
HPRD ID		02094	04300
Ensembl ID		ENSG00000101966
Uniprot IDs		B2R9R2 P98170	A0M8W4 G3V113 Q15819
PDB IDs		1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48	1J74 1J7D 1ZGU 3VON 4EPO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Apoptotic Process Activation Of Innate Immune Response Programmed Cell Death Cell Death Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Stress Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Stress Positive Regulation Of Protein Modification Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Protein Metabolic Process Protein Polyubiquitination Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Transferase Activity Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signal Transduction By Phosphorylation Innate Immune Response Regulation Of Signal Transduction Cellular Protein Modification Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Metabolic Process Protein Ubiquitination Regulation Of Apoptotic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Catalytic Activity Regulation Of Cell Death Apoptotic Signaling Pathway Regulation Of Signaling Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Apoptotic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Ubiquitination Protein K63-linked Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Activation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of DNA Repair Regulation Of Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Positive Regulation Of Signal Transduction Response To Stress Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Stress Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Innate Immune Response Histone Ubiquitination Regulation Of Histone Ubiquitination Positive Regulation Of DNA Repair Regulation Of Response To DNA Damage Stimulus Cellular Response To DNA Damage Stimulus Antigen Receptor-mediated Signaling Pathway Cellular Metabolic Process Immune Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Regulation Of Immune System Process DNA Repair Protein Catabolic Process Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Chromatin Organization Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		anthracyclines antiapoptotic apaf bcp carbinol childhood coadministration cruciferous cure doxorubicin dramatic evidenced i3c iap1 indole innovative lymphoblastic modality nalm nontoxic noxa opportunities parp phytochemical potentiates puma topoisomerase vegetables xl	affymetrix anthracycline anthracyclines atm bc bimodal bub1 damaging enable fan1 fanci fashion impair mnat1 msh2 msh6 mtmr15 parp2 pcna pms2 polq recql4 regimens residual rpa3 sensitizing survive taxane top2a
Tagcloud (Difference) ?		antiapoptotic apaf bcp carbinol childhood coadministration cruciferous cure doxorubicin dramatic evidenced i3c iap1 indole innovative lymphoblastic modality nalm nontoxic noxa opportunities parp phytochemical potentiates puma topoisomerase vegetables xl	affymetrix anthracycline atm bc bimodal bub1 damaging enable fan1 fanci fashion impair mnat1 msh2 msh6 mtmr15 parp2 pcna pms2 polq recql4 regimens residual rpa3 sensitizing survive taxane top2a
Tagcloud (Intersection) ?		anthracyclines