SERPINB1 and ELANE

Number of citations of the paper that reports this interaction (PMID 10924364)
1

Data Source:
HPRD (in vitro)

		SERPINB1	ELANE
Gene Name		serpin peptidase inhibitor, clade B (ovalbumin), member 1	elastase, neutrophil expressed
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Membrane Extracellular Vesicular Exosome	Extracellular Region Cytoplasm Cell Surface Transcriptional Repressor Complex Secretory Granule Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	RNA Polymerase II Transcription Corepressor Activity Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Collagen Catabolic Process Response To Lipopolysaccharide Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Leukocyte Migration Negative Regulation Of Chemotaxis Neutrophil Mediated Killing Of Fungus
Pathways			Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs			Pegfilgrastim Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 ONO-6818
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ELANE PRTN3 XPO1	30 interactors: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NL SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS
Entrez ID		1992	1991
HPRD ID		00555	00554
Ensembl ID		ENSG00000021355	ENSG00000197561
Uniprot IDs		P30740	P08246
PDB IDs		4GA7	1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Neutrophil Mediated Killing Of Fungus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Response To Yeast Mature Conventional Dendritic Cell Differentiation Ribosomal Large Subunit Export From Nucleus Positive Regulation Of Interleukin-8 Biosynthetic Process Killing By Host Of Symbiont Cells Ribosomal Subunit Export From Nucleus Acute Inflammatory Response To Antigenic Stimulus Regulation Of Interleukin-8 Biosynthetic Process Negative Regulation Of Phagocytosis Negative Regulation Of Interleukin-8 Production Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Export From Nucleus Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemotaxis Defense Response To Fungus Intracellular Transport Of Virus Positive Regulation Of Cell Proliferation Positive Regulation Of Interleukin-8 Production Protein Export From Nucleus Interaction With Symbiont Inflammatory Response To Antigenic Stimulus Leukocyte Mediated Cytotoxicity Regulation Of Centrosome Duplication Negative Regulation Of Cytokine Biosynthetic Process Dendritic Cell Differentiation Response To Fungus Regulation Of Centrosome Cycle Negative Regulation Of Endocytosis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Chemokine Production Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Phagocytosis Positive Regulation Of Cytokine Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Acute Inflammatory Response Regulation Of Cell Proliferation	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Wound Healing Regulation Of Proteolysis Response To Wounding Blood Coagulation Hemostasis Cell Activation Regulation Of Cellular Protein Metabolic Process Inflammatory Response Regulation Of Body Fluid Levels Negative Regulation Of Catalytic Activity Platelet Degranulation Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Defense Response Negative Regulation Of Protein Metabolic Process Regulation Of Blood Coagulation Platelet Activation Response To Stress Blood Circulation Regulation Of Wound Healing Regulation Of Catalytic Activity Response To External Stimulus Response To Stimulus Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Blood Coagulation Negative Regulation Of Plasminogen Activation Response To Other Organism Secretion By Cell Exocytosis Negative Regulation Of Fibrinolysis Positive Regulation Of Coagulation Response To Biotic Stimulus Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Regulation Of Fibrinolysis Negative Regulation Of Blood Coagulation Regulation Of Chemotaxis Blood Vessel Morphogenesis Secretion Negative Regulation Of Coagulation
Tagcloud ?		a431 a431cells allowing annotation apoptotic components cytochrome cytoskeletal dnaaseii egf epidermoid evenly exploited modeled networks overexpress proteome proteomic proteomics signalling split stream sub suppressors tp53 trigger triggering undergo unlikely	absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype
Tagcloud (Difference) ?		a431 a431cells allowing annotation apoptotic components cytochrome cytoskeletal dnaaseii egf epidermoid evenly exploited modeled networks overexpress proteome proteomic proteomics signalling split stream sub suppressors tp53 trigger triggering undergo unlikely	absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype
Tagcloud (Intersection) ?