SERPINB1 and ELANE

Number of citations of the paper that reports this interaction (PubMedID 10924364)
0

Data Source:
HPRD (in vitro)

		SERPINB1	ELANE
Description		serpin family B member 1	elastase, neutrophil expressed
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Endosome Early Endosome Membrane Extracellular Matrix Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Cytolytic Granule Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Cytosol Cell Surface Transcription Repressor Complex Secretory Granule Extracellular Matrix Cytoplasmic Vesicle Azurophil Granule Lumen Specific Granule Lumen Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Protease Binding Transcription Corepressor Activity Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Cytokine Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell Migration Negative Regulation Of Interleukin-1 Beta Production Type B Pancreatic Cell Proliferation Regulation Of Protein Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Leukocyte Migration Involved In Inflammatory Response Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Proteolysis Intracellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Response To Lipopolysaccharide Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Defense Response To Fungus Leukocyte Migration Negative Regulation Of Chemotaxis Pyroptotic Inflammatory Response Neutrophil-mediated Killing Of Gram-negative Bacterium Neutrophil-mediated Killing Of Fungus Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Neutrophil degranulation CASP4 inflammasome assembly	Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Pyroptosis Neutrophil degranulation Antimicrobial peptides Regulation of Complement cascade Expression of NOTCH2NL genes
Drugs			Alpha-1-proteinase inhibitor Mdl 101,146 Freselestat Elafin Lupeol Ursolic acid
Diseases			Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		BMI at 5 years old ( 31575865) Cerebrospinal fluid AB1-42 levels ( 28247064)	Blood protein levels ( 30072576)
Interacting Genes		4 interacting genes: CDC42 ELANE PRTN3 XPO1	31 interacting genes: ACE2 CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NLA SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS1
Entrez ID		1992	1991
HPRD ID		00555	00554
Ensembl ID		ENSG00000021355	ENSG00000197561
Uniprot IDs		P30740 V9HWH1	P08246
PDB IDs		4GA7	1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW 6E69 6F5M 6SMA 7CBK 7WHU 8D4Q 8D4U 8D7I 8D7K 8G24 8G25 8G26 8QGX 8VK5 9ASS 9ASX 9ATK 9ATU
Enriched GO Terms of Interacting Partners?		Leukocyte Migration Cell-cell Junction Organization Positive Regulation Of Cell Population Proliferation Endothelin Receptor Signaling Pathway Involved In Heart Process Cell Migration GBD Domain Binding Storage Vacuole Phagocytic Vesicle Myeloid Leukocyte Differentiation Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Azurophil Granule Lumen Antibacterial Peptide Biosynthetic Process Neutrophil-mediated Killing Of Fungus Serine-type Peptidase Activity Serine-type Endopeptidase Activity Cellular Response To Triglyceride Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Cell Motility Response To Triglyceride Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Organelle Localization Myeloid Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Neutrophil-mediated Killing Of Gram-negative Bacterium Mature Conventional Dendritic Cell Differentiation Neutrophil Extravasation Annulate Lamellae Cellular Response To Salt Ribosomal Small Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Leading Edge Membrane Thioesterase Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Neuron Fate Determination Mononuclear Cell Differentiation Establishment Of Golgi Localization Golgi Transport Complex Regulation Of Endocytosis Positive Regulation Of Leukocyte Tethering Or Rolling Neutrophil-mediated Killing Of Bacterium Positive Regulation Of Catalytic Activity Ribosomal Subunit Export From Nucleus Leukocyte Differentiation Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Regulation Of Transport Hydrolase Activity	Extracellular Region Peptidase Inhibitor Activity Extracellular Space Serine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Body Fluid Levels Circulatory System Process Blood Coagulation Coagulation Hemostasis Regulation Of Response To Wounding Extracellular Exosome Extracellular Matrix Regulation Of Wound Healing Defense Response Blood Circulation Inflammatory Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protease Binding Regulation Of Biological Quality Cell Surface Positive Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Negative Regulation Of Proteolysis Negative Regulation Of Plasminogen Activation Positive Regulation Of Coagulation Regulation Of Multicellular Organismal Process Chronic Inflammatory Response Endoplasmic Reticulum Lumen Positive Regulation Of Vasculature Development Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Fibrinolysis Immune System Process External Side Of Plasma Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Proteolysis System Process Positive Regulation Of Interleukin-8 Production Fibrinolysis Signaling Receptor Binding Positive Regulation Of Wound Healing Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Reactive Oxygen Species Metabolic Process
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