SERPINB1

Description		serpin family B member 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Endosome Early Endosome Membrane Extracellular Matrix Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Cytolytic Granule Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell Migration Negative Regulation Of Interleukin-1 Beta Production Type B Pancreatic Cell Proliferation Regulation Of Protein Metabolic Process
Pathways		Neutrophil degranulation CASP4 inflammasome assembly
Drugs
Diseases
GWAS		BMI at 5 years old ( 31575865) Cerebrospinal fluid AB1-42 levels ( 28247064)
Interacting Genes		4 interacting genes: CDC42 ELANE PRTN3 XPO1
Entrez ID		1992
HPRD ID		00555
Ensembl ID		ENSG00000021355
Uniprot IDs		P30740 V9HWH1
PDB IDs		4GA7
Enriched GO Terms of Interacting Partners?		Leukocyte Migration Cell-cell Junction Organization Positive Regulation Of Cell Population Proliferation Endothelin Receptor Signaling Pathway Involved In Heart Process Cell Migration GBD Domain Binding Storage Vacuole Phagocytic Vesicle Myeloid Leukocyte Differentiation Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Azurophil Granule Lumen Antibacterial Peptide Biosynthetic Process Neutrophil-mediated Killing Of Fungus Serine-type Peptidase Activity Serine-type Endopeptidase Activity Cellular Response To Triglyceride Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Cell Motility Response To Triglyceride Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Organelle Localization Myeloid Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Neutrophil-mediated Killing Of Gram-negative Bacterium Mature Conventional Dendritic Cell Differentiation Neutrophil Extravasation Annulate Lamellae Cellular Response To Salt Ribosomal Small Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Leading Edge Membrane Thioesterase Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Neuron Fate Determination Mononuclear Cell Differentiation Establishment Of Golgi Localization Golgi Transport Complex Regulation Of Endocytosis Positive Regulation Of Leukocyte Tethering Or Rolling Neutrophil-mediated Killing Of Bacterium Positive Regulation Of Catalytic Activity Ribosomal Subunit Export From Nucleus Leukocyte Differentiation Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Regulation Of Transport Hydrolase Activity
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