SERPINB1 and XPO1

Number of citations of the paper that reports this interaction (PubMedID 22833565)
68

Data Source:
BioGRID (unspecified method)

		SERPINB1	XPO1
Description		serpin family B member 1	exportin 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Endosome Early Endosome Membrane Extracellular Matrix Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Cytolytic Granule Extracellular Exosome	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Membrane Protein-containing Complex Ribonucleoprotein Complex
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding Protein Domain Specific Binding Small GTPase Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell Migration Negative Regulation Of Interleukin-1 Beta Production Type B Pancreatic Cell Proliferation Regulation Of Protein Metabolic Process	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Transcription By RNA Polymerase II MRNA Export From Nucleus Protein Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Response To Xenobiotic Stimulus Regulation Of Centrosome Duplication Protein Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Regulation Of Protein Catabolic Process Ribosome Biogenesis Regulation Of Protein Export From Nucleus MRNA Transport Cellular Response To Triglyceride Cellular Response To Salt
Pathways		Neutrophil degranulation CASP4 inflammasome assembly	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation Heme signaling NPAS4 regulates expression of target genes Maturation of hRSV A proteins Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Selinexor
Diseases
GWAS		BMI at 5 years old ( 31575865) Cerebrospinal fluid AB1-42 levels ( 28247064)	Atrial fibrillation ( 29892015) Eosinophil count ( 27863252 32888494) Erectile dysfunction ( 30583798) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Urinary sodium excretion ( 31409800) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: CDC42 ELANE PRTN3 XPO1	86 interacting genes: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 BRCA2 CCND1 CDC25A CDC42 CDCA4 CDK1 CDKN1B CEBPA CHEK1 CHORDC1 CIITA CRK DDX3X DESI1 DR1 E2F4 E2F5 EIF4E EIF5A ERF FBXO7 FILNC1 FOXO4 HDAC3 HNF4A HSPA9 HSPB1 IRF5 KIF17 LINC01554 LRPPRC MAPK6 NF2 NMD3 NOSIP NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 OGT ORC1 PHAX PHB1 PKIA RAD51 RAN RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SMURF2 SNUPN SOX2 STAT1 STRADA SUMO2 TERF2IP TERT TOP2A TOP2B TP53 TP73
Entrez ID		1992	7514
HPRD ID		00555	03975
Ensembl ID		ENSG00000021355	ENSG00000082898
Uniprot IDs		P30740 V9HWH1	A0A7I2V2Y6 A0A7I2V461 A0A7I2V6B9 B3KWD0 O14980
PDB IDs		4GA7	1W9C 2L1L 3GB8 4BSM 4BSN 5DIS 6TVO 7B51 9B62
Enriched GO Terms of Interacting Partners?		Leukocyte Migration Cell-cell Junction Organization Positive Regulation Of Cell Population Proliferation Endothelin Receptor Signaling Pathway Involved In Heart Process Cell Migration GBD Domain Binding Storage Vacuole Phagocytic Vesicle Myeloid Leukocyte Differentiation Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Azurophil Granule Lumen Antibacterial Peptide Biosynthetic Process Neutrophil-mediated Killing Of Fungus Serine-type Peptidase Activity Serine-type Endopeptidase Activity Cellular Response To Triglyceride Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Cell Motility Response To Triglyceride Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Organelle Localization Myeloid Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Neutrophil-mediated Killing Of Gram-negative Bacterium Mature Conventional Dendritic Cell Differentiation Neutrophil Extravasation Annulate Lamellae Cellular Response To Salt Ribosomal Small Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Leading Edge Membrane Thioesterase Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Neuron Fate Determination Mononuclear Cell Differentiation Establishment Of Golgi Localization Golgi Transport Complex Regulation Of Endocytosis Positive Regulation Of Leukocyte Tethering Or Rolling Neutrophil-mediated Killing Of Bacterium Positive Regulation Of Catalytic Activity Ribosomal Subunit Export From Nucleus Leukocyte Differentiation Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Regulation Of Transport Hydrolase Activity	Nuclear Transport Nucleocytoplasmic Transport Nuclear Export Nucleoplasm Nucleus Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cytoplasm Intracellular Transport Protein Export From Nucleus Regulation Of Primary Metabolic Process RNA Transport Establishment Of Localization In Cell Protein Import Into Nucleus Import Into Nucleus Cellular Localization Intracellular Protein Transport Protein-containing Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Cycle Nuclear Pore Establishment Of Protein Localization To Organelle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Transport Positive Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Protein Localization To Nucleus Cytosol Positive Regulation Of Metabolic Process RNA Export From Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Protein Localization To Organelle Negative Regulation Of Mitotic Cell Cycle DNA Binding MRNA Transport Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of DNA-templated Transcription
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