SERPINB1 and PRTN3

Number of citations of the paper that reports this interaction (PMID 12114510)
8

Data Source:
HPRD (in vitro)

		SERPINB1	PRTN3
Gene Name		serpin peptidase inhibitor, clade B (ovalbumin), member 1	proteinase 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Membrane Extracellular Vesicular Exosome	Extracellular Space Cytosol Plasma Membrane Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Enzyme Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity	Proteolysis Blood Coagulation Positive Regulation Of Cell Proliferation Collagen Catabolic Process Negative Regulation Of Phagocytosis Mature Conventional Dendritic Cell Differentiation
Pathways			Common Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ELANE PRTN3 XPO1	13 interactors: CAMP ELN F2R F2RL1 IL1B IL32 ITGB2 RELA SERPINA1 SERPINB1 SERPINB13 SMAD3 TNF
Entrez ID		1992	5657
HPRD ID		00555	01512
Ensembl ID		ENSG00000021355	ENSG00000196415
Uniprot IDs		P30740	P24158
PDB IDs		4GA7	1FUJ
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Neutrophil Mediated Killing Of Fungus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Response To Yeast Mature Conventional Dendritic Cell Differentiation Ribosomal Large Subunit Export From Nucleus Positive Regulation Of Interleukin-8 Biosynthetic Process Killing By Host Of Symbiont Cells Ribosomal Subunit Export From Nucleus Acute Inflammatory Response To Antigenic Stimulus Regulation Of Interleukin-8 Biosynthetic Process Negative Regulation Of Phagocytosis Negative Regulation Of Interleukin-8 Production Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Export From Nucleus Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemotaxis Defense Response To Fungus Intracellular Transport Of Virus Positive Regulation Of Cell Proliferation Positive Regulation Of Interleukin-8 Production Protein Export From Nucleus Interaction With Symbiont Inflammatory Response To Antigenic Stimulus Leukocyte Mediated Cytotoxicity Regulation Of Centrosome Duplication Negative Regulation Of Cytokine Biosynthetic Process Dendritic Cell Differentiation Response To Fungus Regulation Of Centrosome Cycle Negative Regulation Of Endocytosis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Chemokine Production Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Phagocytosis Positive Regulation Of Cytokine Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Acute Inflammatory Response Regulation Of Cell Proliferation	Response To Other Organism Inflammatory Response Response To Biotic Stimulus Positive Regulation Of Interleukin-8 Production Defense Response Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of Protein Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Proteolysis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Positive Regulation Of Interleukin-6 Production Response To External Stimulus Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Bacterium Regulation Of Cytokine Production Negative Regulation Of Protein Secretion Regulation Of Interleukin-6 Production Positive Regulation Of NF-kappaB Transcription Factor Activity Leukocyte Cell-cell Adhesion Positive Regulation Of Protein Transport Cell Activation Response To Stress Positive Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Vitamin D Biosynthetic Process Sequestering Of Triglyceride Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Lipopolysaccharide Positive Regulation Of Transcription Factor Import Into Nucleus Cellular Response To Molecule Of Bacterial Origin Negative Regulation Of Secretion By Cell Regulation Of Phosphorylation Negative Regulation Of Secretion Positive Regulation Of Phagocytosis Negative Regulation Of Protein Transport Response To Lipid Negative Regulation Of Cellular Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Immune Response Regulation Of Chemokine Production Negative Regulation Of Protein Metabolic Process Regulation Of Renin Secretion Into Blood Stream Immune System Process
Tagcloud ?		a431 a431cells allowing annotation apoptotic components cytochrome cytoskeletal dnaaseii egf epidermoid evenly exploited modeled networks overexpress proteome proteomic proteomics signalling split stream sub suppressors tp53 trigger triggering undergo unlikely	aspartic cathepsin cited2 colonies compromised elastase elementbinding embryogenesis eosinophil fetal gata2 glutamic kit lef lethality lin lineages livers lymphoid manifesting modulator mpo notch1 peroxidase reconstitution sca transactivators uncovers wnt5a
Tagcloud (Difference) ?		a431 a431cells allowing annotation apoptotic components cytochrome cytoskeletal dnaaseii egf epidermoid evenly exploited modeled networks overexpress proteome proteomic proteomics signalling split stream sub suppressors tp53 trigger triggering undergo unlikely	aspartic cathepsin cited2 colonies compromised elastase elementbinding embryogenesis eosinophil fetal gata2 glutamic kit lef lethality lin lineages livers lymphoid manifesting modulator mpo notch1 peroxidase reconstitution sca transactivators uncovers wnt5a
Tagcloud (Intersection) ?