NCBP1 and NCBP2

Number of citations: 20 (PubMedID 7478990)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		NCBP1	NCBP2
Name		nuclear cap binding protein subunit 1	nuclear cap binding protein subunit 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Cap Binding Complex RNA Cap Binding Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Cap Binding Complex RNA Cap Binding Complex Ciliary Basal Body
	Molecular Function	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding MRNA Binding Protein Binding Molecular Adaptor Activity	RNA Cap Binding RNA 7-methylguanosine Cap Binding Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding SnRNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Spliceosomal Complex Assembly Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Cap-dependent Translational Initiation 7-methylguanosine MRNA Capping MRNA Processing RNA Catabolic Process MRNA Export From Nucleus SnRNA Export From Nucleus Regulation Of Translation Regulation Of Translational Initiation Histone MRNA Metabolic Process RNA Splicing RNA Metabolic Process MRNA Metabolic Process Positive Regulation Of Cell Growth Regulatory NcRNA-mediated Gene Silencing Primary MiRNA Processing MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing MRNA Transcription By RNA Polymerase II Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Transport Defense Response To Virus Positive Regulation Of RNA Binding	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Cap-dependent Translational Initiation MRNA Processing MRNA Export From Nucleus SnRNA Export From Nucleus Regulation Of Translation Regulation Of Translational Initiation Histone MRNA Metabolic Process RNA Splicing MRNA Metabolic Process Regulatory NcRNA-mediated Gene Silencing Primary MiRNA Processing MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing MRNA Transcription By RNA Polymerase II MRNA Cis Splicing, Via Spliceosome Positive Regulation Of RNA Export From Nucleus MRNA Transport
Pathways		SLBP independent Processing of Histone Pre-mRNAs Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Abortive elongation of HIV-1 transcript in the absence of Tat snRNP Assembly RNA Polymerase II Pre-transcription Events FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Processing of Intronless Pre-mRNAs Signaling by FGFR2 IIIa TM Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nuclear RNA decay	SLBP independent Processing of Histone Pre-mRNAs Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Abortive elongation of HIV-1 transcript in the absence of Tat snRNP Assembly RNA Polymerase II Pre-transcription Events FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Processing of Intronless Pre-mRNAs Signaling by FGFR2 IIIa TM Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nuclear RNA decay
GWAS		Thyroid cancer (Papillary, radiation-related) ( 20350937 )	Malaria ( 31844061 ) Night sleep phenotypes ( 27126917 ) Pre-treatment viral load in HIV-1 infection ( 31219150 )
Novel Interactors		2 novel interactors: NUP214 SELENOS	None recorded
Interacting Genes		19 interacting genes: BNIP1 BNIP2 BNIP3 DSCR9 EIF4G1 EIF4G2 HNRNPF HNRNPH1 LINC01554 NCBP2 PSTPIP1 PTEN RNF10 RNF20 RNF40 RPS6KB1 SNRPA1 STAU1 ZDHHC17	7 interacting genes: DDX39B EIF4G1 EIF5 HNRNPF HNRNPH1 LZTS2 NCBP1
Entrez ID		4686	22916
HPRD ID		02717	05503
Ensembl ID		ENSG00000136937	ENSG00000114503
Uniprot IDs		Q09161	F6WVI0 P52298
PDB IDs		1H2T 1H2U 1H2V 1H6K 1N52 1N54 3FEX 3FEY 5OO6 5OOB 6D0Y 7ABG 8BY6 8PMP 8PNT 8SRR 8SUY	1H2T 1H2U 1H2V 1H6K 1N52 1N54 3FEX 3FEY 5OO6 5OOB 6D0Y 7ABG 8BY6 8PMP 8PNT 8SRR 8SUY
GO Terms Enriched among Interactors		Response To Oxygen-glucose Deprivation Regulation Of Translational Initiation HULC Complex Cap-dependent Translational Initiation Nuclear Envelope Multicellular Organismal Response To Stress Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Macromolecule Catabolic Process Catalytic Step 2 Spliceosome Regulation Of Cell Cycle Response To Nutrient Levels Macromolecule Metabolic Process Negative Regulation Of Autophagy Regulation Of Mitotic Cell Cycle Translation Factor Activity, RNA Binding MRNA Binding Ubiquitin-specific Protease Binding Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Cell Death Post-transcriptional Regulation Of Gene Expression Cytoplasmic Translational Initiation Regulation Of Autophagy Protein Metabolic Process Mitochondrion Autophagosome Adaptor Activity Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Fear Response Behavioral Fear Response Behavioral Defense Response RNA Splicing Negative Regulation Of Synaptic Vesicle Clustering Proteolysis Involved In Protein Catabolic Process Cytoplasmic Side Of Nuclear Pore Perforant Pathway To Dendrate Granule Cell Synapse Histone H2B C-terminal K Residue Ubiquitin Ligase Activity Spliceosomal Complex Regulation Of Translation RNA Binding Translation Initiation Factor Activity MRNA Processing Mitochondrial Outer Membrane Apoptotic Process In Response To Mitochondrial Fragmentation Cellular Response To Oxidative Stress Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cap-dependent Translational Initiation RNA Binding Translational Initiation RNA Splicing Regulation Of Translational Initiation MRNA Processing Nuclear Export Spliceosomal Complex Regulation Of RNA Splicing Protein-RNA Complex Assembly MRNA Metabolic Process Cytoplasmic Translational Initiation MRNA Binding Nuclear Transport Nucleocytoplasmic Transport Spliceosomal Complex Assembly Translation Initiation Factor Activity RNA Processing MRNA Export From Nucleus Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Ribonucleoprotein Complex Positive Regulation Of RNA Binding Primary Ureteric Bud Growth Regulation Of Translation RNA Export From Nucleus Catalytic Step 2 Spliceosome MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Eukaryotic Initiation Factor EIF2 Binding Nucleic Acid Binding RNA Metabolic Process RNA Cap Binding Complex MRNA Transport Nuclear Cap Binding Complex Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression SnRNA Export From Nucleus RNA Transport Positive Regulation Of Cell Growth Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of MRNA 3'-end Processing Molecular Adaptor Activity Macromolecule Metabolic Process Positive Regulation Of Translation In Response To Stress 7-methylguanosine MRNA Capping ATP-dependent Protein Binding U4 SnRNA Binding