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LAMTOR3 and SUFU
Number of citations of the paper that reports this interaction (PMID
14611647
)
23
Data Source:
HPRD
(two hybrid)
LAMTOR3
SUFU
Gene Name
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
suppressor of fused homolog (Drosophila)
Image
Gene Ontology Annotations
Cellular Component
Focal Adhesion
Extracellular Vesicular Exosome
Ragulator Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Primary Cilium
Ciliary Tip
Ciliary Base
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Protein Complex Scaffold
Transcription Corepressor Activity
Signal Transducer Activity
Protein Binding
Beta-catenin Binding
Transcription Factor Binding
Protein Kinase Binding
Biological Process
Positive Regulation Of TOR Signaling
Cellular Protein Localization
Positive Regulation Of GTPase Activity
Cellular Response To Amino Acid Stimulus
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Skeletal System Development
Neural Tube Closure
Heart Looping
Regulation Of Transcription, DNA-templated
Proteolysis
Signal Transduction
Multicellular Organismal Development
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification
Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification
Negative Regulation Of Transcription Factor Import Into Nucleus
Cytoplasmic Sequestering Of Transcription Factor
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Skin Development
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways
Hedgehog 'off' state
Hedgehog 'on' state
Signaling by Hedgehog
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS
Prostate cancer (
23535732
)
Protein-Protein Interactions
16 interactors:
ADAMTS10
BHMT
CEBPZ
CPNE6
IBTK
LAMTOR2
MAP2K1
MAP2K2
MAPK1
MAPK3
MBD2
NIF3L1
PDE4DIP
QARS
SUFU
UBR1
26 interactors:
BTRC
GLI1
GLI2
GLI3
GLIS3
HDX
HMGA1
HNRNPA1
LAMTOR3
LGALS3
MID1IP1
NCOA3
PEX26
PIAS1
QPRT
RBPJ
RCN3
RNF19A
SAP18
SETDB1
STK36
ZNF219
ZNF263
ZNF446
ZNF747
ZNF764
Entrez ID
8649
51684
HPRD ID
04485
06124
Ensembl ID
ENSG00000109270
ENSG00000107882
Uniprot IDs
Q9UHA4
Q9UMX1
PDB IDs
1SKO
2ZL1
3CPT
1M1L
Enriched GO Terms of Interacting Partners
?
Regulation Of Golgi Inheritance
Regulation Of Golgi Organization
Regulation Of Early Endosome To Late Endosome Transport
Activation Of MAPKK Activity
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Cellular Response To Organonitrogen Compound
Response To Organonitrogen Compound
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Activation Of Protein Kinase Activity
Toll-like Receptor Signaling Pathway
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of MAPK Activity
Activation Of Innate Immune Response
Insulin Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Caveolin-mediated Endocytosis
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Protein Kinase Activity
Positive Regulation Of Innate Immune Response
Regulation Of Stress-activated MAPK Cascade
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Regulation Of Intracellular Transport
Regulation Of Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of MAP Kinase Activity
Neurotrophin TRK Receptor Signaling Pathway
Cellular Response To Insulin Stimulus
Ras Protein Signal Transduction
MAPK Cascade
Neurotrophin Signaling Pathway
Positive Regulation Of Kinase Activity
Fc-epsilon Receptor Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Regulation Of Innate Immune Response
RNA Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Smoothened Signaling Pathway
Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Nitrogen Compound Metabolic Process
Notochord Regression
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Mammary Gland Morphogenesis
Macromolecule Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification
Tube Morphogenesis
Smoothened Signaling Pathway
Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning
Ventral Midline Development
Gland Development
Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Organ Formation
Proximal/distal Pattern Formation
Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation
Pituitary Gland Development
Gland Morphogenesis
Positive Regulation Of Neural Precursor Cell Proliferation
Mammary Gland Development
Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation
Tagcloud
?
beta1
blots
cck
colorectal
constructed
counting
enhances
gli1
hedgehog
hh
ht29
infecting
integrin
interference
invasion
itgb1
kit
lentiviral
lentivirus
malignancies
migrating
rnai
shh
sonic
transwell
unrelated
vectors
xenografted
xenografting
Tagcloud (Difference)
?
beta1
blots
cck
colorectal
constructed
counting
enhances
gli1
hedgehog
hh
ht29
infecting
integrin
interference
invasion
itgb1
kit
lentiviral
lentivirus
malignancies
migrating
rnai
shh
sonic
transwell
unrelated
vectors
xenografted
xenografting
Tagcloud (Intersection)
?