LAMTOR3 and MAP2K2

Number of citations of the paper that reports this interaction (PubMedID 9733512)
0

Data Source:
HPRD (in vitro)

		LAMTOR3	MAP2K2
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	mitogen-activated protein kinase kinase 2
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GO Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Endosome Late Endosome Plasma Membrane Focal Adhesion Endosome Membrane Membrane Late Endosome Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Ragulator Complex FNIP-folliculin RagC/D GAP	Extracellular Region Nucleus Cytoplasm Mitochondrion Early Endosome Late Endosome Peroxisomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule Cell-cell Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Activator Activity Molecular Adaptor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Kinase Activity Transferase Activity PDZ Domain Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Molecular Adaptor Activity Scaffold Protein Binding Protein Serine Kinase Activity
	Biological Process	Intracellular Protein Localization Regulation Of TOR Signaling Positive Regulation Of TOR Signaling TORC1 Signaling Positive Regulation Of MAPK Cascade Cellular Response To Amino Acid Stimulus Protein Localization To Cell Junction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of TORC1 Signaling	MAPK Cascade Heart Development Positive Regulation Of Gene Expression Schwann Cell Development Thyroid Gland Development Regulation Of Stress-activated MAPK Cascade Peptidyl-serine Autophosphorylation ERBB2-ERBB3 Signaling Pathway Myelination Positive Regulation Of DNA-templated Transcription Insulin-like Growth Factor Receptor Signaling Pathway Thymus Development Regulation Of Axon Regeneration Positive Regulation Of Axonogenesis Face Development Lung Morphogenesis Trachea Formation Epithelial Cell Proliferation Involved In Lung Morphogenesis ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Positive Regulation Of Cell Motility Regulation Of Early Endosome To Late Endosome Transport
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes MAP2K and MAPK activation Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1	MAPK1 (ERK2) activation Frs2-mediated activation Signal transduction by L1 Uptake and function of anthrax toxins RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by RAF1 mutants
Drugs			Bosutinib Trametinib Selumetinib Binimetinib Fostamatinib Pimasertib
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Mean reticulocyte volume ( 32888494)	Eosinophil count ( 32888494) Heel bone mineral density ( 30598549) Height ( 29782485) Lymphocyte count ( 32888494) Pulse pressure ( 30224653) White blood cell count ( 32888494)
Interacting Genes		20 interacting genes: ADAMTS10 APOL6 BHMT CEBPZ CPNE6 IBTK LAMTOR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MBD2 NIF3L1 PDE4DIP QARS1 SUFU TFE3 TGM7 UBR1 ZSCAN4	20 interacting genes: ARAF BRAF CASP9 CCNDBP1 CNKSR1 COPS5 DUSP3 GRIN1 GRIN2D HNRNPK LAMTOR3 LIG4 MAPK1 MAPK3 MAPK8 MOS RAF1 RGS12 RIPOR2 ZNF207
Entrez ID		8649	5605
HPRD ID		04485	03164
Ensembl ID		ENSG00000109270	ENSG00000126934
Uniprot IDs		Q9UHA4	B3KS97 P36507
PDB IDs		1SKO 2ZL1 3CPT 5X6U 5X6V 5Y39 5Y3A 5YK3 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB	1S9I 4H3Q
Enriched GO Terms of Interacting Partners?		Regulation Of Golgi Inheritance Regulation Of Golgi Organization Trachea Formation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Stress-activated MAPK Cascade Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Animal Organ Formation Face Development ERBB2 Signaling Pathway Lung Morphogenesis Thyroid Gland Development Insulin-like Growth Factor Receptor Signaling Pathway Bergmann Glial Cell Differentiation Thymus Development ERK1 And ERK2 Cascade Late Endosome Glial Cell Development ERBB Signaling Pathway Myelination Interleukin-34-mediated Signaling Pathway Axon Ensheathment Hematopoietic Or Lymphoid Organ Development Astrocyte Differentiation Regulation Of Intracellular Transport Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Epithelial Cell Proliferation Involved In Lung Morphogenesis Cardiac Neural Crest Cell Development Involved In Heart Development Outer Ear Morphogenesis Molecular Adaptor Activity Regulation Of MAPK Cascade MAP-kinase Scaffold Activity MAPK Cascade MAP Kinase Kinase Activity MAP Kinase Activity Pseudopodium Regulation Of DNA-templated Transcription Gland Development Regulation Of RNA Biosynthetic Process Positive Regulation Of Macrophage Chemotaxis Glial Cell Differentiation Positive Regulation Of Neuroinflammatory Response Regulation Of Cellular Localization Regulation Of Cellular Response To Stress Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Cytoplasm	MAPK Cascade MAP Kinase Kinase Kinase Activity Face Development Thyroid Gland Development Intracellular Signal Transduction Protein Serine Kinase Activity ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Intracellular Signaling Cassette Protein Serine/threonine Kinase Activity Thymus Development Regulation Of Signal Transduction Regulation Of MAPK Cascade MAP Kinase Activity Pseudopodium Protein Kinase Activity Schwann Cell Development ERBB Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Peptidyl-serine Phosphorylation Stress-activated MAPK Cascade ERBB2 Signaling Pathway Regulation Of Intracellular Signal Transduction Stress-activated Protein Kinase Signaling Cascade Signal Transduction Kinase Activity Interleukin-34-mediated Signaling Pathway Hematopoietic Or Lymphoid Organ Development Regulation Of Peptidyl-serine Phosphorylation Cytoplasm Regulation Of Chromosome Organization Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Synaptic Transmission NMDA Glutamate Receptor Activity Glutamate Binding Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Granulocyte Chemotaxis Response To Epidermal Growth Factor Negative Regulation Of Apoptotic Process ERK1 And ERK2 Cascade Long-term Synaptic Potentiation Protein Phosphorylation Negative Regulation Of Programmed Cell Death NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity
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