LAMTOR3 and IBTK

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		LAMTOR3	IBTK
Gene Name		late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	inhibitor of Bruton agammaglobulinemia tyrosine kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Focal Adhesion Extracellular Vesicular Exosome Ragulator Complex	Nucleoplasm Cytoplasm Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Complex Scaffold	Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity
	Biological Process	Positive Regulation Of TOR Signaling Cellular Protein Localization Positive Regulation Of GTPase Activity Cellular Response To Amino Acid Stimulus	Negative Regulation Of Protein Phosphorylation Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Protein Tyrosine Kinase Activity
Pathways
Drugs
Diseases
GWAS			Corneal structure ( 23291589)
Protein-Protein Interactions		16 interactors: ADAMTS10 BHMT CEBPZ CPNE6 IBTK LAMTOR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MBD2 NIF3L1 PDE4DIP QARS SUFU UBR1	5 interactors: BTK LAMTOR3 PPP1CA PRKCB PRKD1
Entrez ID		8649	25998
HPRD ID		04485	12105
Ensembl ID		ENSG00000109270	ENSG00000005700
Uniprot IDs		Q9UHA4	Q9P2D0
PDB IDs		1SKO 2ZL1 3CPT
Enriched GO Terms of Interacting Partners?		Regulation Of Golgi Inheritance Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport Activation Of MAPKK Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Organonitrogen Compound Response To Organonitrogen Compound Vascular Endothelial Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase Activity Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of MAPK Activity Activation Of Innate Immune Response Insulin Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Innate Immune Response Regulation Of Stress-activated MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Intracellular Transport Regulation Of Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of MAP Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Ras Protein Signal Transduction MAPK Cascade Neurotrophin Signaling Pathway Positive Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Innate Immune Response	Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Regulation Of Sequence-specific DNA Binding Transcription Factor Activity B Cell Receptor Signaling Pathway Positive Regulation Of Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of B Cell Cytokine Production Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Angiogenesis Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Kinase D Signaling Cellular Response To Molecule Of Fungal Origin Histone H3-T6 Phosphorylation B Cell Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Histone Deacetylase Activity Peptidyl-amino Acid Modification Apoptotic Process Cellular Response To Oxidative Stress Programmed Cell Death Protein Autophosphorylation Response To Molecule Of Fungal Origin Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Death Death Regulation Of Angiogenesis Regulation Of Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Histone Deacetylase Activity Phosphate-containing Compound Metabolic Process Positive Regulation Of Deacetylase Activity Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Protein Phosphorylation Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of B Cell Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Glycogen Catabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell Death Histamine Secretion By Mast Cell Negative Regulation Of Transport
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