LAMTOR3 and MAP2K1

Number of citations of the paper that reports this interaction (PMID 9733512)
108

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		LAMTOR3	MAP2K1
Gene Name		late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	mitogen-activated protein kinase kinase 1
Image
Gene Ontology Annotations	Cellular Component	Focal Adhesion Extracellular Vesicular Exosome Ragulator Complex	Nucleus Cytoplasm Mitochondrion Early Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Microtubule Organizing Center Cytosol Microtubule Plasma Membrane Focal Adhesion Cell Cortex Axon Dendrite Cytoplasm Perikaryon Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Complex Scaffold	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Phosphatase Activity Protein Binding ATP Binding Ras GTPase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Positive Regulation Of TOR Signaling Cellular Protein Localization Positive Regulation Of GTPase Activity Cellular Response To Amino Acid Stimulus	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Vascular Smooth Muscle Contraction Movement Of Cell Or Subcellular Component Chemotaxis Response To Oxidative Stress Cell Cycle Arrest Mitotic Nuclear Division Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Cell Proliferation Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Neuron Differentiation Keratinocyte Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Ras GTPase Activity Melanosome Transport Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Homotypic Cell-cell Adhesion Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of Cell Differentiation Positive Regulation Of Ras Protein Signal Transduction Vesicle Transport Along Microtubule Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Golgi Inheritance Response To Axon Injury Cell Motility Protein Heterooligomerization Response To Glucocorticoid Stress-activated MAPK Cascade Placenta Blood Vessel Development Labyrinthine Layer Development Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Cellular Senescence Regulation Of Early Endosome To Late Endosome Transport
Pathways			Signaling by GPCR Signaling by FGFR in disease MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Uptake and actions of bacterial toxins Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade SOS-mediated signalling Uptake and function of anthrax toxins SHC-mediated signalling Signaling by PDGF DAP12 interactions TRIF-mediated TLR3/TLR4 signaling ERK1 activation SHC-related events triggered by IGF1R GRB2 events in EGFR signaling ERK1 activation Signaling by ERBB4 Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Signalling to RAS Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-1 signaling Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Signalling to ERKs Prolonged ERK activation events ERK activation Axon guidance IRS-mediated signalling Toll Like Receptor 7/8 (TLR7/8) Cascade L1CAM interactions IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade VEGFA-VEGFR2 Pathway Activated TLR4 signalling IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling ERK activation RAF phosphorylates MEK Downstream signaling of activated FGFR TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Signaling by Insulin receptor Innate Immune System Signalling by NGF Signal transduction by L1 Insulin receptor signalling cascade SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane SHC-related events MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Drugs			K-252a 5-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Difluoro-2-[(2-Fluoro-4-Iodophenyl)Amino]Benzamide Bosutinib (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE Trametinib
Diseases
GWAS
Protein-Protein Interactions		16 interactors: ADAMTS10 BHMT CEBPZ CPNE6 IBTK LAMTOR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MBD2 NIF3L1 PDE4DIP QARS SUFU UBR1	41 interactors: ARAF BANP BIRC6 BRAF CASP9 CDK5 CPNE1 CPNE4 EGFR ELK1 EP300 GRB10 HNRNPD HRAS KSR1 KSR2 LAMTOR3 MAP3K4 MAP3K8 MAPK1 MAPK14 MAPK3 MAPK8 MAPK8IP3 MYC PAK1 PARVA PEBP1 PEBP4 PLK3 PPARG PRKCI PRKCZ RAF1 RPS6KA2 RPS6KA4 SUMO1 TRAF3 TRAF6 TRIB1 WNK1
Entrez ID		8649	5604
HPRD ID		04485	01469
Ensembl ID		ENSG00000109270
Uniprot IDs		Q9UHA4	A4QPA9 B4DFY5 Q02750
PDB IDs		1SKO 2ZL1 3CPT	1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3VVH 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK
Enriched GO Terms of Interacting Partners?		Regulation Of Golgi Inheritance Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport Activation Of MAPKK Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Organonitrogen Compound Response To Organonitrogen Compound Vascular Endothelial Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase Activity Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of MAPK Activity Activation Of Innate Immune Response Insulin Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Innate Immune Response Regulation Of Stress-activated MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Intracellular Transport Regulation Of Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of MAP Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Ras Protein Signal Transduction MAPK Cascade Neurotrophin Signaling Pathway Positive Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Innate Immune Response	Regulation Of Protein Metabolic Process MAPK Cascade Signal Transduction By Phosphorylation Regulation Of Cellular Protein Metabolic Process Phosphorylation Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Protein Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of MAPK Cascade Regulation Of Phosphorus Metabolic Process Phosphate-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Activation Of Protein Kinase Activity Cellular Response To Organic Substance Regulation Of Signal Transduction Response To Organic Substance Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Programmed Cell Death Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Cellular Response To Growth Factor Stimulus Cell Death Death Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Response To Growth Factor Positive Regulation Of Kinase Activity Signaling Cellular Protein Modification Process Regulation Of Kinase Activity Signal Transduction Cell Communication Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity
Tagcloud ?			actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns kif5b nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Difference) ?			actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns kif5b nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Intersection) ?