PLIN2 and UBR1

Number of citations of the paper that reports this interaction (PubMedID 37057345)
38

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		PLIN2	UBR1
Description		perilipin 2	ubiquitin protein ligase E3 component n-recognin 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol Plasma Membrane Membrane	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity L-leucine Binding
	Biological Process	Response To Xenobiotic Stimulus Positive Regulation Of Triglyceride Storage Long-chain Fatty Acid Transport Lipid Storage Cellular Response To Glucose Starvation Lipid Droplet Disassembly	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Negative Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To L-leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways		PPARA activates gene expression Lipophagy Chaperone Mediated Autophagy Late endosomal microautophagy MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Johanson-Blizzard syndrome
GWAS		Abdominal aortic calcification levels ( 31659325) Systolic blood pressure ( 30578418)	Appendicular lean mass ( 33097823) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)
Interacting Genes		9 interacting genes: ABHD5 ARF1 DESI2 HTATIP2 MAPK10 OGT POGZ SFT2D2 UBR1	33 interacting genes: ANXA3 ARL15 ARL3 ARL4D ATF3 BCL2L1 BTBD2 CDC42 CDC6 COXFA4L2 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NR3C1 NTAN1 NTAQ1 NUDT3 PKNOX1 PLIN2 PTPRS RGS4 SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2
Entrez ID		123	197131
HPRD ID		00057	09342
Ensembl ID		ENSG00000147872	ENSG00000159459
Uniprot IDs		Q6FHZ7 Q99541	Q8IWV7
PDB IDs			3NY1 5TDC
Enriched GO Terms of Interacting Partners?			Protein-N-terminal Asparagine Amidohydrolase Activity HULC Complex Ubiquitin Conjugating Enzyme Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
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