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EGFR and MAPK8IP2
Number of citations of the paper that reports this interaction (PMID
16273093
)
170
Data Source:
BioGRID
(unspecified method)
EGFR
MAPK8IP2
Gene Name
epidermal growth factor receptor
mitogen-activated protein kinase 8 interacting protein 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Extracellular Space
Nucleus
Cytoplasm
Endosome
Endoplasmic Reticulum Membrane
Plasma Membrane
Focal Adhesion
Cell Surface
Endosome Membrane
Membrane
Integral Component Of Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
AP-2 Adaptor Complex
Nuclear Membrane
Receptor Complex
Membrane Raft
Perinuclear Region Of Cytoplasm
Shc-EGFR Complex
Cytoplasm
Neuronal Cell Body
Protein Complex
Neuronal Postsynaptic Density
Molecular Function
Glycoprotein Binding
Chromatin Binding
Double-stranded DNA Binding
MAP Kinase Kinase Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Receptor Signaling Protein Tyrosine Kinase Activity
Transmembrane Signaling Receptor Activity
Epidermal Growth Factor-activated Receptor Activity
Integrin Binding
Protein Binding
ATP Binding
Enzyme Binding
Protein Kinase Binding
Protein Phosphatase Binding
Nitric-oxide Synthase Regulator Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Heterodimerization Activity
Epidermal Growth Factor Binding
Actin Filament Binding
Beta-amyloid Binding
MAP-kinase Scaffold Activity
Structural Molecule Activity
Protein Binding
Kinesin Binding
Protein Kinase Binding
Protein Kinase Activator Activity
Protein Complex Binding
Biological Process
MAPK Cascade
Activation Of MAPKK Activity
Ossification
Liver Development
Embryonic Placenta Development
Positive Regulation Of Protein Phosphorylation
Hair Follicle Development
Translation
Response To Stress
Response To Osmotic Stress
Response To Oxidative Stress
Signal Transduction
Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Axon Guidance
Salivary Gland Morphogenesis
Learning Or Memory
Circadian Rhythm
Cell Proliferation
Positive Regulation Of Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Magnesium Ion Homeostasis
Diterpenoid Metabolic Process
Single Organismal Cell-cell Adhesion
Peptidyl-tyrosine Phosphorylation
Alkanesulfonate Metabolic Process
Cerebral Cortex Cell Migration
Lung Development
Positive Regulation Of Cell Migration
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Superoxide Anion Generation
Response To Cobalamin
Response To Hydroxyisoflavone
Positive Regulation Of Catenin Import Into Nucleus
Cellular Response To Drug
Fc-epsilon Receptor Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Phosphorylation
Ovulation Cycle
Hydrogen Peroxide Metabolic Process
Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAP Kinase Activity
Tongue Development
Innate Immune Response
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of DNA Repair
Positive Regulation Of DNA Replication
Positive Regulation Of Vasoconstriction
Positive Regulation Of Vasodilation
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Astrocyte Activation
Positive Regulation Of Fibroblast Proliferation
Digestive Tract Morphogenesis
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Inflammatory Response
Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Nitric-oxide Synthase Activity
Protein Insertion Into Membrane
Response To Calcium Ion
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Synaptic Transmission, Glutamatergic
Morphogenesis Of An Epithelial Fold
Response To UV-A
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Amino Acid Stimulus
Cellular Response To Mechanical Stimulus
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Estradiol Stimulus
Cellular Response To Dexamethasone Stimulus
MAPK Cascade
Behavioral Fear Response
Signal Complex Assembly
JNK Cascade
Mating Behavior
Regulation Of Receptor Activity
Positive Regulation Of Stress-activated MAPK Cascade
Social Behavior
Positive Regulation Of Protein Kinase Activity
Regulation Of JNK Cascade
Nonassociative Learning
Dendrite Morphogenesis
Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Excitatory Postsynaptic Membrane Potential
Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity
Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways
Signaling by the B Cell Receptor (BCR)
Signaling by GPCR
Signaling by FGFR in disease
Signaling by EGFRvIII in Cancer
PLCG1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
Signaling by SCF-KIT
DAP12 signaling
Downstream signaling events of B Cell Receptor (BCR)
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PI3K/AKT activation
PI-3K cascade
Gastrin-CREB signalling pathway via PKC and MAPK
Signaling by PDGF
EGFR downregulation
DAP12 interactions
GAB1 signalosome
GRB2 events in EGFR signaling
Signaling by ERBB4
Constitutive PI3K/AKT Signaling in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
PI3K events in ERBB4 signaling
EGFR interacts with phospholipase C-gamma
Signaling by ERBB2
Signaling by EGFR
Downstream signal transduction
Signaling by EGFR in Cancer
Fc epsilon receptor (FCERI) signaling
PI3K/AKT Signaling in Cancer
Adaptive Immune System
Axon guidance
PIP3 activates AKT signaling
L1CAM interactions
EGFR Transactivation by Gastrin
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
Innate Immune System
Signalling by NGF
Signal transduction by L1
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
Inhibition of Signaling by Overexpressed EGFR
Signaling by FGFR
SHC1 events in EGFR signaling
Constitutive Signaling by EGFRvIII
Drugs
Cetuximab
Trastuzumab
Lidocaine
Gefitinib
Erlotinib
Lapatinib
Panitumumab
Flavopiridol
Vandetanib
S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE
N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE
Afatinib
Diseases
GWAS
Glioma (
21531791
)
Protein-Protein Interactions
279 interactors:
ABL1
ABL2
ACTA1
ADRBK1
ADRM1
AGTR1
AHNAK
AHSA1
AIP
AKAP12
ALCAM
ALDOA
AMH
ANKS1A
ANKS1B
ANXA1
APBA3
APBB1
APBB2
APBB3
APPL1
AR
AREG
ARF4
ATIC
ATP1A1
ATP1B1
ATP5C1
BLK
BMX
BTC
CALM1
CALM2
CALM3
CAMK2A
CAMK2G
CAMLG
CASP1
CAV1
CAV2
CAV3
CBL
CBLB
CBLC
CBR1
CD44
CD59
CD82
CDC25A
CDH1
CEACAM1
CEBPB
CEND1
CFL1
CISH
CLNK
CLTA
CLTCL1
CMTM8
CNTN2
COL9A3
COX2
CRK
CSRP1
CTNNB1
CTNND1
DCBLD2
DCN
DCTN2
DEGS1
DNAJC4
DOK2
DOK4
DOK5
DOK6
DUSP3
DYNC1H1
EEF1G
EGF
ELF3
EPB41
EPHA2
EPPK1
EPS15
EPS8
ERBB2
ERBB3
ERBB4
EREG
ERRFI1
ESR1
EZR
FAH
FAS
FBXO25
FER
FES
FKBP4
FKBP8
FN1
GAB1
GABARAPL2
GAPDH
GNAI2
GOT1
GPM6B
GRB10
GRB14
GRB2
GRB7
HBEGF
HEXIM1
HGS
HIST3H3
HOXC10
HSP90B1
HSPA1A
HSPA4
HSPA8
HTT
ICAM1
INPPL1
IRS1
IRS4
ITGA5
JAK2
JUP
KCTD9P2
KRT17
KRT18
KRT7
KRT8
LYN
MAP2K1
MAP3K12
MAP3K14
MAP4K1
MAPK1
MAPK14
MAPK8IP1
MAPK8IP2
MAST1
MATR3
MDH1
MEGF6
MET
MGARP
MOB4
MUC1
NCAM1
NCK1
NCK2
NDN
NEDD4
NUMB
NUMBL
OAZ1
OLFM1
PAK1
PCNA
PDCD6IP
PDGFRB
PDK3
PIK3C2A
PIK3C2B
PIK3R1
PIK3R2
PIK3R3
PIN4
PITPNA
PKIA
PLCG1
PLCG2
PLD1
PLD2
PLEC
PLSCR1
PML
PPP5C
PRCC
PRDX1
PRKACA
PRKAR1A
PRKAR1B
PRKCA
PRKCB
PRKCD
PRKD1
PSMA7
PSMD4
PTGDS
PTK2
PTK2B
PTK6
PTPN1
PTPN11
PTPN12
PTPN2
PTPN6
PTPRJ
PTPRS
RAB3A
RAP1GDS1
RASA1
RGS16
RIN2
RIPK1
RNF115
RNF126
RQCD1
RUSC2
S100A7
S100A9
SCAMP1
SCAMP3
SEC13
SEPP1
SFN
SGSM2
SH2B1
SH2B3
SH2D1A
SH2D2A
SH2D3A
SH3BGRL3
SHC1
SHC2
SHC3
SLA
SLC3A2
SLC9A3R1
SMURF2
SNRPD2
SNX1
SNX2
SNX4
SNX6
SOCS1
SOCS3
SOCS4
SOCS5
SOCS7
SORBS2
SOS1
SOS2
SPARCL1
SPCS2
SRC
STAM2
STAT1
STAT3
STAT5A
STAT5B
STIP1
SYK
TGFA
TJP1
TLN1
TMCO3
TNC
TNK2
TNS4
TPI1
TPM1
TRPV1
TUBA1A
TUBA4A
UBB
UBE2V2
UCHL1
UROD
VAPA
VAV1
VAV2
VAV3
XRCC6
YWHAZ
ZAP70
ZPR1
52 interactors:
ADRB2
AFG3L2
APP
ASRGL1
BBS10
C14orf1
CFL1
CHN1
CRMP1
DUSP16
EGFR
ERBB2
EZH2
FGF12
FSCN1
GBP2
ITSN1
KIFC2
KLC1
LRP1
LRP2
LRP8
MAGED4B
MAP2K3
MAP2K7
MAP3K10
MAP3K11
MAP3K12
MAPK10
MAPK8
MAPK8IP1
MAPK8IP3
MAPK9
MASP1
NDUFS6
PLXNA3
PRSS23
RAI1
RBX1
RPS6KB2
SMARCB1
SMS
SYNE2
TIAM1
TP53BP2
UNC119
VCP
VPS33B
VRK2
YY1AP1
ZNF593
ZNF784
Entrez ID
1956
23542
HPRD ID
00579
09674
Ensembl ID
ENSG00000146648
ENSG00000008735
Uniprot IDs
E9PFD7
P00533
Q13387
PDB IDs
1DNQ
1DNR
1IVO
1M14
1M17
1MOX
1NQL
1XKK
1YY9
1Z9I
2EB2
2EB3
2EXP
2EXQ
2GS2
2GS6
2GS7
2ITN
2ITO
2ITP
2ITQ
2ITT
2ITU
2ITV
2ITW
2ITX
2ITY
2ITZ
2J5E
2J5F
2J6M
2JIT
2JIU
2JIV
2KS1
2M20
2RF9
2RFD
2RFE
2RGP
3B2U
3B2V
3BEL
3BUO
3C09
3G5V
3G5Y
3GOP
3GT8
3IKA
3LZB
3NJP
3OB2
3OP0
3P0Y
3PFV
3POZ
3QWQ
3UG1
3UG2
3VJN
3VJO
3VRP
3VRR
3W2O
3W2P
3W2Q
3W2R
3W2S
3W32
3W33
4G5J
4G5P
4HJO
4I1Z
4I20
4I21
4I22
4I23
4I24
4JQ7
4JQ8
4JR3
4JRV
4KRL
4KRM
4KRO
4KRP
4LI5
4LL0
Enriched GO Terms of Interacting Partners
?
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Signaling
Response To Stimulus
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Response To Organic Substance
Regulation Of Signal Transduction
Response To Stress
Cellular Response To Stimulus
Cell Communication
Cellular Response To Organic Substance
Signaling
Signal Transduction
Innate Immune Response
Positive Regulation Of Signal Transduction
Cell Surface Receptor Signaling Pathway
Regulation Of Phosphorylation
Defense Response
Wound Healing
Regulation Of Kinase Activity
Regulation Of Phosphorus Metabolic Process
Immune System Process
Regulation Of Catalytic Activity
Response To Wounding
Intracellular Signal Transduction
Immune Response
Regulation Of Protein Metabolic Process
Regulation Of Protein Kinase Activity
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Neurotrophin TRK Receptor Signaling Pathway
Locomotion
Regulation Of Protein Phosphorylation
Movement Of Cell Or Subcellular Component
Neurotrophin Signaling Pathway
Positive Regulation Of Metabolic Process
Regulation Of Intracellular Signal Transduction
Cellular Response To Organonitrogen Compound
System Development
Response To Organonitrogen Compound
Regulation Of Immune System Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Cellular Response To Peptide Hormone Stimulus
Anatomical Structure Development
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Catalytic Activity
Cellular Response To Peptide
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
JNK Cascade
Signal Transduction By Phosphorylation
MAPK Cascade
Regulation Of Protein Kinase Activity
Regulation Of MAPK Cascade
Regulation Of Kinase Activity
Regulation Of Phosphorylation
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Kinase Activity
JUN Phosphorylation
Regulation Of MAP Kinase Activity
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Transferase Activity
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Positive Regulation Of Signal Transduction
Positive Regulation Of MAP Kinase Activity
Response To Stress
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of MAPK Cascade
Regulation Of Signal Transduction
Response To Light Stimulus
Response To External Stimulus
Response To Radiation
Regulation Of Signaling
Intracellular Signal Transduction
Activation Of Protein Kinase Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Axon Guidance
Regulation Of Intracellular Signal Transduction
Signal Transduction
Axonogenesis
Phosphorylation
Cell Part Morphogenesis
Axon Development
Response To Stimulus
Cell Morphogenesis Involved In Neuron Differentiation
Response To Abiotic Stimulus
Protein Phosphorylation
Cellular Response To Stress
Signaling
Tagcloud
?
12q
12q21
14q31
15q25
16q23
18p
19q13
20p12
20pq
20q12
21q21
3p14
4pq
5p14
5q14
6p12
7p12
8q23
cardia
cdkn2
fist
gej
mlvi2
mts1
nrasl3
parentheses
ptpn1
rca1
xpq
xq25
Tagcloud (Difference)
?
12q
12q21
14q31
15q25
16q23
18p
19q13
20p12
20pq
20q12
21q21
3p14
4pq
5p14
5q14
6p12
7p12
8q23
cardia
cdkn2
fist
gej
mlvi2
mts1
nrasl3
parentheses
ptpn1
rca1
xpq
xq25
Tagcloud (Intersection)
?