EGFR and ESR1

Number of citations of the paper that reports this interaction (PubMedID 11887937)
0

Data Source:
HPRD (in vitro)

		EGFR	ESR1
Description		epidermal growth factor receptor	estrogen receptor 1
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleus Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cilium Basal Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Cell Junction Endocytic Vesicle Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Nuclear Membrane Ruffle Membrane Protein-containing Complex Ciliary Basal Body Receptor Complex Membrane Raft Perinuclear Region Of Cytoplasm Shc-EGFR Complex Multivesicular Body, Internal Vesicle Lumen Intracellular Vesicle	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Protein-containing Complex
	Molecular Function	Nucleotide Binding Virus Receptor Activity Chromatin Binding Double-stranded DNA Binding Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Epidermal Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Kinase Binding Protein Phosphatase Binding Protein Tyrosine Kinase Activator Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Cadherin Binding Epidermal Growth Factor Binding Actin Filament Binding ATPase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TFIIB-class Transcription Factor Binding Transcription Coregulator Binding Transcription Corepressor Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Calmodulin Binding Beta-catenin Binding Zinc Ion Binding Lipid Binding TBP-class Protein Binding Enzyme Binding Protein Kinase Binding Nitric-oxide Synthase Regulator Activity Nuclear Estrogen Receptor Activity Nuclear Estrogen Receptor Binding Estrogen Response Element Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding ATPase Binding 14-3-3 Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MAPK Cascade Cell Morphogenesis Ossification Embryonic Placenta Development Positive Regulation Of Protein Phosphorylation Hair Follicle Development Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Salivary Gland Morphogenesis Learning Or Memory Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Epidermis Development Cerebral Cortex Cell Migration Neuron Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Peptidyl-serine Phosphorylation ERBB2-EGFR Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Protein Catabolic Process Positive Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell Positive Regulation Of Fibroblast Proliferation Digestive Tract Morphogenesis Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Peptidyl-tyrosine Phosphorylation Protein Insertion Into Membrane Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Morphogenesis Of An Epithelial Fold Eyelid Development In Camera-type Eye Response To UV-A Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of MiRNA Transcription Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Cardiocyte Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Antral Ovarian Follicle Growth Epithelial Cell Development Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Androgen Metabolic Process Male Gonad Development Negative Regulation Of Gene Expression Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Estrogen Receptor Signaling Pathway Response To Estradiol Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Steroid Hormone Receptor Signaling Pathway Negative Regulation Of DNA-binding Transcription Factor Activity Response To Estrogen Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Stem Cell Differentiation Regulation Of Inflammatory Response Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of DNA-binding Transcription Factor Activity RNA Polymerase II Preinitiation Complex Assembly Uterus Development Vagina Development Prostate Epithelial Cord Elongation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Mammary Gland Branching Involved In Pregnancy Mammary Gland Alveolus Development Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Protein Localization To Chromatin Cellular Response To Estrogen Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Oxygen-containing Compound Negative Regulation Of MiRNA Transcription Regulation Of Epithelial Cell Apoptotic Process
Pathways		Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Signal transduction by L1 Constitutive Signaling by EGFRvIII Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Extra-nuclear estrogen signaling NOTCH3 Activation and Transmission of Signal to the Nucleus HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Respiratory syncytial virus (RSV) attachment and entry Developmental Lineage of Mammary Gland Myoepithelial Cells	Nuclear signaling by ERBB4 PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors RUNX1 regulates estrogen receptor mediated transcription ESR-mediated signaling RUNX1 regulates transcription of genes involved in WNT signaling Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Extra-nuclear estrogen signaling Estrogen-dependent gene expression Mitochondrial unfolded protein response (UPRmt) Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells
Drugs		Cetuximab Lidocaine Gefitinib Erlotinib Lapatinib Panitumumab Alvocidib IGN311 Matuzumab Vandetanib Rindopepimut Canertinib Pelitinib Varlitinib AV-412 S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE PD-168393 Afatinib Osimertinib Necitumumab Foreskin keratinocyte (neonatal) Depatuxizumab mafodotin Icotinib Neratinib Dacomitinib Fostamatinib Poziotinib Zalutumumab Brigatinib Olmutinib Zanubrutinib Abivertinib Mobocertinib Almonertinib Amivantamab	Diethylstilbestrol Chlorotrianisene Conjugated estrogens Desogestrel Levonorgestrel Progesterone Lindane Raloxifene Toremifene Medroxyprogesterone acetate Testosterone Mitotane Estrone Tamoxifen Hexachlorophene Estradiol Ethynodiol diacetate Dobutamine Clomifene Dienestrol Fulvestrant Norgestimate Ethinylestradiol Melatonin Trilostane Naloxone Fluoxymesterone Estramustine Mestranol Danazol Oxybenzone Allylestrenol Zinc Genistein Prasterone Benzophenone Equilin Compound 19 Resveratrol Compound 18 Phthalic Acid Pyrazole Stanolone Naringenin Compound 4-D 1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Yl)-Phenyl]-2-Phenyl-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol Quercetin Afimoxifene 2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)-Phenyl]-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol Estriol Estrone sulfate Quinestrol Phenolphthalein Permethrin Ospemifene AP1081 Custirsen NP-50301 CHF 4227 TAS-108 Lasofoxifene Arzoxifene Elacestrant Bazedoxifene Methyltestosterone beta-Naphthoflavone 17-METHYL-17-ALPHA-DIHYDROEQUILENIN din-6-yl)phenol [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL (2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL Hexestrol dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate Erteberel N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL 2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol Tibolone Eugenol Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, B Polyestradiol phosphate Norethynodrel Octocrylene Homosalate Enzacamene Zeranol Ractopamine Gestrinone Estetrol Propyl Gallate Ormeloxifene 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol Testosterone cypionate Testosterone enanthate Stanolone acetate Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate Zinc acetate Zinc chloride Zinc sulfate, unspecified form Estriol tripropionate Fluoroestradiol F-18
Diseases		Laryngeal cancer Cervical cancer Oral cancer Gastric cancer Choriocarcinoma Esophageal cancer Glioma Bladder cancer
GWAS		Dental caries (decayed and filled deciduous teeth) ( 31533690) Glioblastoma ( 28346443 29743610) Glioblastoma (age-stratified) ( 30152087) Glioma ( 21531791 28346443 29743610) Haemorrhoidal disease ( 33888516) Impulsivity ( 30718321) Initial alcohol sensitivity ( 30276832) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Non-glioblastoma glioma ( 28346443) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Refractive astigmatism ( 30306274) Subjective response to lithium treatment ( 26503763)	Age at first birth ( 27089180 34211149 27798627) Age at first sexual intercourse ( 27089180 34211149) Alcohol dependence ( 19581569) Anxiety ( 31906708) Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone mineral density ( 23437003) Bone mineral density (hip) ( 18445777 19801982 19079262) Bone mineral density (spine) ( 30172743 27424934 18445777 26911590 19079262 19801982) Bone mineral density (Ward's triangle area) ( 27397699) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 21263130 22383897 29059683 25327703 31757997 27117709 23535729 23535733 20453838 19219042) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 29058716) Breast size ( 29855537 27182965 22747683) Chronic myeloid leukemia ( 21540461) Developmental language disorder ( 27016271) Diastolic blood pressure ( 30578418) Endometriosis ( 28537267) Fractures ( 30158200) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 31453325 28869591 30598549 30048462) Heel bone mineral density variance ( 31453325) Height ( 25282103 33713608 28552196 31562340 20881960 23563607) Hip circumference adjusted for BMI ( 34021172) Interleukin-10 levels in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683) Mammographic density (dense area) ( 25342443) Menarche (age at onset) ( 25231870) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 28135244 30578418 27841878) Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (dichotomous) ( 28628665) Smoking status (current vs former) ( 27393504) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 30578418 27841878) Uterine fibroids ( 31649266) Waist circumference adjusted for body mass index ( 28552196) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Western dietary pattern ( 28644415)
Interacting Genes		412 interacting genes: ABL2 ACTA1 ADRM1 AGTR1 AHNAK AHSA1 AIP AKAP12 ALCAM AMH AMPH ANKS1A ANKS1B ANXA1 AOPEP APBA3 APBB1 APBB3 APP APPL1 AR AREG ARF4 ARHGEF12 ARHGEF7 ARRB2 ATP1A1 ATP1B1 ATP5F1C AXL B4GALT1 BAIAP2 BCAR3 BLK BLNK BMX BTC CALM1 CALM2 CALM3 CAMK2A CAMK2G CAMLG CASP1 CAV1 CAV2 CAV3 CBL CBLB CBLC CCDC88A CD44 CD82 CDC25A CDC34 CDH1 CDH5 CEACAM1 CEBPB CEND1 CLNK CLTA CLTCL1 CMTM8 CNOT9 CNTN2 COL9A3 CRK CSRP1 CTNNB1 CTNND1 CTTN CYLC2 DCBLD2 DCN DCTN2 DDX17 DEGS1 DIAPH1 DNAJC4 DOK2 DOK4 DOK5 DOK6 DUSP19 DUSP3 DYNC1H1 EGF ELF3 EPB41 EPHA2 EPPK1 EPS15 EPS8 ERBB2 ERBB3 ERBB4 EREG ERRFI1 ESR1 EZR FAH FANCC FAS FBXL2 FBXO25 FER FES FGR FKBP4 FKBP8 FN1 FNDC3B FRAT2 FRK GAB1 GABARAPL2 GAPDH GGA1 GGA3 GJB1 GNAI2 GNAS GOT1 GPM6B GPNMB GRAP2 GRB10 GRB14 GRB2 GRB7 GRIN2B GRK2 H3-4 HBEGF HCK HDAC7 HEMGN HEXIM1 HGS HOXC10 HPN HSH2D HSP90AA1 HSP90AB1 HSP90B1 HSPA1A HSPA4 HSPA8 HTT ICAM1 IKBKG IL13RA2 IL5RA ILKAP INPPL1 IQGAP1 IRS1 IRS4 ITGA5 ITGB1 ITGB2 ITK ITSN2 JAK2 JUP KCTD9P2 KEAP1 KRT17 KRT18 KRT7 KRT8 LAT LCK LCP2 LINC01139 LRP1 LRRK1 LYN MAP2K1 MAP3K12 MAP3K14 MAP3K3 MAP4K1 MAPK1 MAPK14 MAPK3 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 MAPT MAST1 MATR3 MDH1 MEGF6 MET MGARP MIF MOB4 MT-CO2 MTDH MUC1 MUC4 NANS NCAM1 NCK1 NCK2 NDN NEDD4 NF2 NHERF1 NIBAN2 NR3C1 NRG1 NTRK2 NUMB NUMBL OAZ1 OLFM1 PAK1 PCNA PDCD6IP PDGFRA PDGFRB PDK3 PDP1 PELI1 PFKP PIK3C2A PIK3C2B PIK3CA PIK3R1 PIK3R2 PIK3R3 PIM1 PIN4 PITPNA PKIA PLCG1 PLCG2 PLD1 PLD2 PLEC PLSCR1 PML PPARG PPM1A PPM1B PPP2CB PPP3CB PPP5C PRCC PRDX1 PRKACA PRKAR1A PRKAR1B PRKCA PRKCB PRKCD PRKCE PRKCZ PRKD1 PSMA7 PSMD4 PTGDS PTK2 PTK2B PTK6 PTPN1 PTPN11 PTPN12 PTPN18 PTPN2 PTPN20 PTPN22 PTPN6 PTPN7 PTPRB PTPRH PTPRJ PTPRR PTPRS PTPRT PTPRU RAB31 RAB3A RAP1GDS1 RAPGEF1 RASA1 RGS16 RGS2 RGS4 RIMS2 RIN1 RIN2 RIPK1 RNF115 RNF126 RNF128 RNF130 RNF144A RNF167 RRAD RUSC2 S100A4 S100A7 S100A9 SCAMP1 SCAMP3 SEC13 SELENOP SFN SGSM2 SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3A SH2D3C SH3BGRL3 SH3GL3 SHB SHC1 SHC2 SHC3 SHC4 SHD SHE SLA SLA2 SLC3A2 SLC9D1 SMURF2 SNCA SNRPD2 SNX1 SNX2 SNX4 SNX6 SNX9 SOCS1 SOCS2 SOCS3 SOCS4 SOCS5 SOCS6 SOCS7 SORBS2 SOS1 SOS2 SPARCL1 SPCS2 SRC STAM2 STAMBP STAP1 STAP2 STAT1 STAT2 STAT3 STAT5A STAT5B STIP1 STUB1 STX17 STYX SUPT6H SYK TAB1 TEC TGFA TGFB1 TJP1 TLN1 TLR2 TNC TNFRSF1A TNK2 TNS1 TNS2 TNS3 TNS4 TPI1 TPM1 TRAF2 TRMO TRPV1 TSTD2 TUBA1A TUBA4A TXK TXN UBB UBE2V2 UROD VAPA VAV1 VAV2 VAV3 WASF3 WASL XRCC6 YES1 YWHAB YWHAQ YWHAZ ZAP70 ZNF510 ZPR1	370 interacting genes: ACTN4 AHR AKAP13 AKT1 AKT2 ALYREF ANGPTL4 ANP32B AR ARHGEF15 ARID1A ARNT ATAD2 BAG1 BAP1 BARD1 BCAR1 BCAS2 BDNF BRCA1 CALM1 CALM2 CALM3 CAV1 CBLL1 CCND1 CCNH CCNT1 CCT2 CDC25B CDK2 CDK7 CDK8 CDKN1A CEBPA CEBPB CFL1 CHD9 CHUK CITED1 COPS5 CREBBP CSNK2B CSRP1 CTNNB1 CUEDC2 CUL4B CXCL1 DAP3 DARS1 DBN1 DDX1 DDX17 DDX3X DDX5 DDX54 DNMT3L DNTTIP2 DUT EEF2 EGFR EHMT2 EIF2S2 EIF3I EIF4A3 EP300 EPAS1 EPSTI1 ERBB2 ESR2 ESRRA FARSA FBH1 FHL2 FKBP4 FKBP5 FLII FOXK2 FOXO1 FOXO3 FOXO4 FUBP1 GADD45B GADD45G GLCE GNAI1 GRB2 GREB1 GRIP1 GRWD1 GTF2B GTF2H1 H2AC20 H2BC10 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H3-3A H3-3B HBP1 HDAC3 HDAC4 HDAC5 HDAC9 HDLBP HEXIM1 HNF4A HNRNPA1 HNRNPA2B1 HNRNPC HNRNPD HSP90AA1 HSP90AB1 HSP90B1 HSPA4 HSPA8 HSPB1 IGF1R ILF3 ING1 ISL1 ITGB3BP JUN JUNB JUND KARS1 KAT5 KDM5A KIF1A KLF5 KLK5 KLK9 KMT2D KMT5B KRT10 KRT18 KRT19 KRT8 LARS1 LCK LCOR LDB1 LINC00312 LRIF1 MAPK1 MAPK14 MAPK3 MARS1 MDM2 MED1 MED10 MED12 MED13 MED14 MED16 MED17 MED20 MED21 MED23 MED24 MED27 MED6 MED7 MEN1 MGMT MINDY1 MKNK2 MMS19 MNAT1 MPG MSH2 MTA1 MTA2 MTCH2 MTHFD1 MTOR MUC1 MVP MYBBP1A MYH6 NAP1L4 NCL NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOA7 NCOR1 NCOR2 NELFB NFKB1 NONO NPM1 NPPA NR0B1 NR0B2 NR1H4 NR2C1 NR2C2 NR2F1 NR2F6 NRIP1 NSD1 NSD2 NSD3 NSF NUDT21 OTUB1 P4HB PA2G4 PAGR1 PAK1 PAK6 PBXIP1 PDIA3 PELP1 PGC PGR PHB1 PHB2 PIAS1 PIAS2 PIAS3 PIK3R1 PIK3R3 PNRC2 POLR1B POLR2A POLR2D POU2F1 POU2F2 POU4F1 POU4F2 PPARGC1A PPARGC1B PPIB PPID PPP1CA PPP2R1A PQBP1 PRDM2 PRKACA PRKCSH PRMT1 PRMT2 PRPF19 PRPF6 PSMC3IP PSMC5 PSMD1 PSPC1 PTEN PTGES3 PTMA PTPN1 PTPN6 RAC3 RACK1 RANBP9 RARA RBBP4 RBBP7 RBFOX2 RBM23 RBM39 RELA REXO4 RFX4 RGS3 RLIM RNF111 RNF14 RNF4 RPL9 RPS6KA1 RPS6KA3 RTCB RXRA SAFB SAFB2 SARNP SARS2 SEPTIN2 SEPTIN8 SERBP1 SERPINB5 SET SETD7 SFMBT2 SFPQ SHC1 SHMT2 SKIL SKP2 SLC30A9 SMAD2 SMAD3 SMAD4 SMARCA2 SMARCA4 SMARCD1 SMARCD3 SMARCE1 SMC1A SMC3 SMYD2 SND1 SNX6 SOS1 SP1 SP3 SRA1 SRC SREBF1 STAT3 STAT5A STRN STUB1 SUV39H1 SVIL SYNCRIP TADA3 TAF10 TAF1A TAF1B TAF2 TAP1 TBP TCERG1 TCF20 TDG THRA THRB TNFRSF14 TOPBP1 TP53 TRAM1 TRIM24 TRIM25 TRIM28 TRIM59 TRIM8 TRIP4 TRRAP TSC2 TUBA1B TUBA1C TUBB TXNRD1 UBE2I UBE3A UBE4B UBR5 UIMC1 USF1 VAV3 VCP WBP2 WIPI1 XAF1 XBP1 YARS1 YWHAH YWHAQ ZBTB16 ZBTB17 ZNF398
Entrez ID		1956	2099
HPRD ID		00579	00589
Ensembl ID		ENSG00000146648	ENSG00000091831
Uniprot IDs		B7Z2I3 C9JYS6 E7BSV0 F2YGG7 P00533 Q504U8	A0A125SXW3 A8KAF4 G4XH65 H0Y4W6 P03372 Q9UBT1
PDB IDs		1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 1Z9I 2EB2 2EB3 2GS2 2GS6 2GS7 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ 2J5E 2J5F 2J6M 2JIT 2JIU 2JIV 2KS1 2M0B 2M20 2N5S 2RF9 2RFD 2RFE 2RGP 3B2U 3B2V 3BEL 3BUO 3C09 3G5V 3G5Y 3GOP 3GT8 3IKA 3LZB 3NJP 3OB2 3OP0 3P0Y 3PFV 3POZ 3QWQ 3UG1 3UG2 3VJN 3VJO 3VRP 3VRR 3W2O 3W2P 3W2Q 3W2R 3W2S 3W32 3W33 4G5J 4G5P 4HJO 4I1Z 4I20 4I21 4I22 4I23 4I24 4JQ7 4JQ8 4JR3 4JRV 4KRL 4KRM 4KRO 4KRP 4LI5 4LL0 4LQM 4LRM 4R3P 4R3R 4R5S 4RIW 4RIX 4RIY 4RJ4 4RJ5 4RJ6 4RJ7 4RJ8 4TKS 4UIP 4UV7 4WD5 4WKQ 4WRG 4ZAU 4ZJV 4ZSE 5C8K 5C8M 5C8N 5CAL 5CAN 5CAO 5CAP 5CAQ 5CAS 5CAU 5CAV 5CNN 5CNO 5CZH 5CZI 5D41 5EDP 5EDQ 5EDR 5EM5 5EM6 5EM7 5EM8 5FED 5FEE 5FEQ 5GMP 5GNK 5GTY 5GTZ 5HCX 5HCY 5HCZ 5HG5 5HG7 5HG8 5HG9 5HIB 5HIC 5J9Y 5J9Z 5JEB 5LV6 5SX4 5SX5 5U8L 5UG8 5UG9 5UGA 5UGB 5UGC 5UWD 5WB7 5WB8 5X26 5X27 5X28 5X2A 5X2C 5X2F 5X2K 5XDK 5XDL 5XGM 5XGN 5XWD 5Y25 5Y9T 5YU9 5ZTO 5ZWJ 6ARU 6B3S 6D8E 6DUK 6JRJ 6JRK 6JRX 6JWL 6JX0 6JX4 6JXT 6JZ0 6LUB 6LUD 6P1D 6P1L 6P8Q 6S89 6S8A 6S9B 6S9C 6S9D 6TFU 6TFV 6TFW 6TFY 6TFZ 6TG0 6TG1 6V5N 6V5P 6V66 6V6K 6V6O 6VH4 6VHN 6VHP 6WA2 6WAK 6WXN 6XL4 6Z4B 6Z4D 7A2A 7A6I 7A6J 7A6K 7AEI 7AEM 7B85 7ER2 7JXI 7JXK 7JXL 7JXM 7JXP 7JXQ 7JXW 7K1H 7K1I 7KXZ 7KY0 7LEN 7LFR 7LFS 7LG8 7LGS 7LTX 7OM4 7OXB 7SI1 7SYD 7SYE 7SZ0 7SZ1 7SZ5 7SZ7 7T4I 7T4J 7TVD 7U98 7U99 7U9A 7UKV 7UKW 7VRA 7VRE 7ZYM 7ZYN 7ZYP 7ZYQ 8A27 8A2A 8A2B 8A2D 8D73 8D76 8DSW 8EME 8F1H 8F1W 8F1X 8F1Y 8F1Z 8FV3 8FV4 8G63 8GB4 8GK5 8H7X 8HGO 8HGP 8HGS 8HV1 8HV2 8HV3 8HV4 8HV5 8HV6 8HV7 8HV8 8HV9 8HVA 8HY7 8KFQ 8PNZ 8PO0 8PO1 8PO2 8PO3 8PO4 8S1M 8SC7 8TJL 8TO3 8TO4 8UKV 8UKW 8UKX 8WD4 9D3V 9D3W 9EWS 9EWT 9FQP 9FQS 9FRD 9GC4 9GC5 9GC6 9GDV 9H46 9HBO	1A52 1ERE 1ERR 1G50 1GWQ 1GWR 1HCP 1HCQ 1L2I 1PCG 1QKT 1QKU 1R5K 1SJ0 1UOM 1X7E 1X7R 1XP1 1XP6 1XP9 1XPC 1XQC 1YIM 1YIN 1ZKY 2AYR 2B1V 2B1Z 2B23 2BJ4 2FAI 2G44 2G5O 2I0J 2IOG 2IOK 2JF9 2JFA 2LLO 2LLQ 2OCF 2OUZ 2P15 2POG 2Q6J 2Q70 2QA6 2QA8 2QAB 2QE4 2QGT 2QGW 2QH6 2QR9 2QSE 2QXM 2QXS 2QZO 2R6W 2R6Y 2YAT 2YJA 3CBM 3CBO 3CBP 3DT3 3ERD 3ERT 3HLV 3HM1 3L03 3OS8 3OS9 3OSA 3Q95 3UU7 3UUA 3UUC 3UUD 4AA6 4DMA 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4JC3 4JDD 4MG5 4MG6 4MG7 4MG8 4MG9 4MGA 4MGB 4MGC 4MGD 4O6F 4PP6 4PPP 4PPS 4PXM 4Q13 4Q50 4TUZ 4TV1 4XI3 4ZN7 4ZN9 4ZNH 4ZNS 4ZNT 4ZNU 4ZNV 4ZNW 5AAU 5AAV 5ACC 5AK2 5DI7 5DID 5DIE 5DIG 5DK9 5DKB 5DKE 5DKG 5DKS 5DL4 5DLR 5DMC 5DMF 5DP0 5DRJ 5DRM 5DTV 5DU5 5DUE 5DUG 5DUH 5DVS 5DVV 5DWE 5DWG 5DWI 5DWJ 5DX3 5DXB 5DXE 5DXG 5DXK 5DXM 5DXP 5DXQ 5DXR 5DY8 5DYB 5DYD 5DZ0 5DZ1 5DZ3 5DZH 5DZI 5E0W 5E0X 5E14 5E15 5E19 5E1C 5EGV 5EHJ 5EI1 5EIT 5FQP 5FQR 5FQS 5FQT 5FQV 5GS4 5GTR 5HYR 5JMM 5KCC 5KCD 5KCE 5KCF 5KCT 5KCU 5KCW 5KD9 5KR9 5KRA 5KRC 5KRF 5KRH 5KRI 5KRJ 5KRK 5KRL 5KRM 5KRO 5N10 5T0X 5T1Z 5T92 5T97 5TLD 5TLF 5TLG 5TLL 5TLM 5TLO 5TLP 5TLT 5TLU 5TLV 5TLX 5TLY 5TM1 5TM2 5TM3 5TM4 5TM5 5TM6 5TM7 5TM8 5TM9 5TML 5TMM 5TMO 5TMQ 5TMR 5TMS 5TMT 5TMU 5TMV 5TMW 5TMZ 5TN1 5TN3 5TN4 5TN5 5TN6 5TN7 5TN8 5TN9 5TNB 5U2B 5U2D 5UFW 5UFX 5W9C 5W9D 5WGD 5WGQ 6B0F 6C42 6CBZ 6CHW 6CHZ 6CZN 6D0F 6DF6 6DFN 6HHP 6HKB 6HKF 6HMU 6IAR 6OWC 6PET 6PFM 6PIT 6PSJ 6SBO 6SQ0 6SUO 6TJM 6TL3 6V87 6V8T 6VGH 6VJD 6VPF 6WOK 6ZOQ 6ZOR 6ZOS 7B9M 7B9R 7B9T 7BA3 7BA5 7BA6 7BA7 7BA8 7BA9 7BAA 7BAB 7JHD 7KBS 7MSA 7N9O 7NDO 7NEL 7NFB 7NFW 7NIZ 7OPW 7OQ7 7OQ8 7PWT 7PWZ 7QVJ 7QVL 7R62 7RKE 7RNM 7RRX 7RRY 7RRZ 7RS0 7RS1 7RS2 7RS3 7RS4 7RS7 7RS8 7RS9 7SFO 7T2X 7TE7 7UJ7 7UJ8 7UJC 7UJF 7UJM 7UJO 7UJW 7UJY 7WNV 7Y8F 7Y8G 7YMK 8AFN 8AI0 8ALR 8ALT 8ALV 8ALW 8AM7 8ANF 8AOY 8APS 8AQ1 8AQC 8AQE 8AQZ 8AR4 8AR5 8ARG 8ARO 8ARQ 8ARR 8ARW 8ARX 8ARY 8ARZ 8AS1 8AT9 8ATP 8AU2 8AUS 8AUY 8AV3 8AV4 8AV7 8AV8 8AWG 8AXE 8AXU 8AZE 8B39 8BWJ 8BWX 8BWZ 8BX0 8BX3 8BX4 8BXI 8BXM 8BXN 8BXO 8BXQ 8BXS 8BY9 8BYB 8BYC 8BYD 8BYE 8BYF 8BYG 8BYO 8BYY 8BYZ 8BZ0 8BZ9 8BZA 8BZB 8BZC 8BZD 8BZE 8BZF 8BZG 8BZH 8BZT 8BZW 8C04 8C0K 8C0L 8C42 8C4F 8C4G 8DU6 8DU8 8DU9 8DUB 8DUC 8DUD 8DUG 8DUH 8DUI 8DUK 8DUS 8DV5 8DV7 8DV8 8DVB 8EV1 8EV2 8VYT 8VYX 8VZ0 8VZ1 8VZP 8VZQ 8W03 8W07 9BPX 9BQE 9BU1
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Phosphotyrosine Residue Binding Regulation Of Cell Communication Cytosol Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Cytoplasm ERBB Signaling Pathway Plasma Membrane Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Binding Regulation Of Immune Response Regulation Of Immune System Process Intracellular Signaling Cassette Negative Regulation Of Signal Transduction Regulation Of Transport Regulation Of Multicellular Organismal Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Cellular Component Organization Regulation Of Defense Response Non-membrane Spanning Protein Tyrosine Kinase Activity Focal Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Protein Tyrosine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Kinase Binding Positive Regulation Of MAPK Cascade Regulation Of Cell Adhesion Protein Kinase Activity ERBB2 Signaling Pathway Regulation Of Biological Quality Regulation Of Innate Immune Response Insulin Receptor Signaling Pathway Regulation Of Programmed Cell Death Kinase Activity Regulation Of Apoptotic Process Activation Of Immune Response	Nucleoplasm Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Binding Transcription Coactivator Activity Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Chromatin Intracellular Signal Transduction Nucleobase-containing Compound Metabolic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Binding Nuclear Receptor-mediated Signaling Pathway Macromolecule Metabolic Process RNA Metabolic Process DNA-templated Transcription Transcription Coregulator Activity Chromatin Organization Chromatin Remodeling Hormone-mediated Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway DNA Binding Nuclear Estrogen Receptor Binding
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