EFNB2 and GRIP1

Number of citations of the paper that reports this interaction (PubMedID 9883737)
0

Data Source:
HPRD (in vitro)

		EFNB2	GRIP1
Description		ephrin B2	glutamate receptor interacting protein 1
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GO Annotations	Cellular Component	Plasma Membrane Adherens Junction Focal Adhesion Membrane Dendrite Presynaptic Membrane Anchoring Junction Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endomembrane System Postsynaptic Density Membrane Dendrite Cytoplasmic Vesicle Cell Projection Neuron Projection Perikaryon Synapse Postsynaptic Membrane
	Molecular Function	Virus Receptor Activity Signaling Receptor Binding Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Ephrin Receptor Binding Receptor Ligand Activity	Protein Binding Beta-catenin Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Angiogenesis Lymph Vessel Development Cell Migration Involved In Sprouting Angiogenesis Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation T Cell Costimulation Adherens Junction Organization Keratinocyte Proliferation Symbiont Entry Into Host Cell Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Venous Blood Vessel Morphogenesis Regulation Of Chemotaxis Cellular Response To Lipopolysaccharide Nephric Duct Morphogenesis Presynapse Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Aorta Morphogenesis Positive Regulation Of Cardiac Muscle Cell Differentiation	Intracellular Signal Transduction Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Positive Regulation Of Neuron Projection Arborization
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	Trafficking of GluR2-containing AMPA receptors
Drugs
Diseases
GWAS		BMI x environmental factors (excluding physical activity) interaction ( 33654129) BMI x environmental factors (including physical activity) interaction ( 33654129) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Metabolite levels ( 23823483) Pediatric autoimmune diseases ( 26301688) Subcutaneous adipose tissue ( 26480920)	Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		23 interacting genes: ANKRD46 DLG4 EPHA3 EPHA4 EPHB1 EPHB2 EPHB4 EPHB6 GRIP1 GRM1 GRM5 HOMER1 NCK2 PDZRN3 PECAM1 PICK1 PSEN1 PTPN13 RELN RGS3 RHBDL2 SDCBP SRC	46 interacting genes: AGAP2 AR BAG4 CARM1 CSPG4 DEPDC1B DZIP3 EEPD1 EFNA5 EFNB1 EFNB2 EP300 ESR1 FGF12 FLII FXR1 FXR2 GPR37 GRIA1 GRIA3 GRIA4 GRIK1 GRIK2 GRIPAP1 GRM2 GRM3 GRM7 H3C1 HUS1 IRF3 KMT5B MFAP3 NCOA6 NEK6 NR3C1 NUMBL PICK1 PPARG PRKD2 PRMT1 RXRA THRA UBE2I VDR WDR6 XDH
Entrez ID		1948	23426
HPRD ID		02754	19086
Ensembl ID		ENSG00000125266	ENSG00000155974
Uniprot IDs		P52799	A0A8V8TLS6 Q9Y3R0
PDB IDs		2HLE 2I85 2VSK 2VSM 2WO2 3GXU 4UF7 6P7Y 6PDL	2JIL
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Ephrin Receptor Activity Dendrite Transmembrane-ephrin Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Modulation Of Chemical Synaptic Transmission Cell Surface Receptor Signaling Pathway Plasma Membrane Neuron Projection Organization Positive Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Regulation Of Synaptic Plasticity Neuron Projection Cell Recognition Protein Tyrosine Kinase Activity Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Postsynaptic Density Regulation Of Synaptic Transmission, Glutamatergic Cell Projection Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Dendritic Spine Organization Cell Migration Regulation Of Synapse Organization Regulation Of Cell Projection Organization Signal Transduction Synapse Negative Regulation Of Cellular Component Organization Positive Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Cell Communication Postsynapse Organization Glutamatergic Synapse Regulation Of Signaling Neuron Projection Guidance Cell Motility Axon Guidance Postsynaptic Membrane Regulation Of Signal Transduction Glutamate Receptor Signaling Pathway Cellular Response To Amyloid-beta Regulation Of Cell Morphogenesis Positive Regulation Of Signaling Cell Adhesion Dendritic Spine Development Regulation Of Postsynapse Organization Regulation Of Nervous System Development G Protein-coupled Glutamate Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Response To Amyloid-beta	Glutamate Receptor Signaling Pathway Regulation Of Cell Communication Glutamate-gated Receptor Activity Nuclear Receptor Activity Presynaptic Membrane Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Positive Regulation Of Signal Transduction Chemical Synaptic Transmission Nuclear Receptor-mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Positive Regulation Of Intracellular Signal Transduction Synaptic Signaling Ligand-gated Monoatomic Ion Channel Activity Regulation Of Biological Quality Glutamate Receptor Activity Regulation Of Synaptic Transmission, Glutamatergic Cell-cell Signaling Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Signaling Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synapse Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Transcription Coregulator Binding Cell Communication Hormone-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Postsynaptic Membrane Signal Transduction Nuclear Steroid Receptor Activity Postsynaptic Density Membrane AMPA Glutamate Receptor Activity Retinoic Acid Receptor Signaling Pathway MRNA Transcription Regulation Of Presynaptic Membrane Potential Regulation Of Synaptic Plasticity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Glutamatergic Synapse Regulation Of Signal Transduction Estrogen Response Element Binding
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