EFNB2 and GRM1

Number of citations of the paper that reports this interaction (PMID 15745950)
7

Data Source:
HPRD (in vivo)

		EFNB2	GRM1
Gene Name		ephrin-B2	glutamate receptor, metabotropic 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Dendrite G-protein Coupled Receptor Dimeric Complex G-protein Coupled Receptor Homodimeric Complex
	Molecular Function	Protein Binding Ephrin Receptor Binding	G-protein Coupled Receptor Activity Protein Binding Glutamate Receptor Activity
	Biological Process	Lymph Vessel Development Cell Migration Involved In Sprouting Angiogenesis Cell Adhesion Cell-cell Signaling Axon Guidance Anatomical Structure Morphogenesis Organ Morphogenesis Negative Regulation Of Keratinocyte Proliferation Viral Process Ephrin Receptor Signaling Pathway Regulation Of Chemotaxis Positive Regulation Of Cardiac Muscle Cell Differentiation	Activation Of MAPKK Activity Activation Of MAPK Activity G-protein Coupled Receptor Signaling Pathway Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Locomotory Behavior Sensory Perception Of Pain Dimeric G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Regulation Of Sensory Perception Of Pain Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To Electrical Stimulus
Pathways		EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs			L-Glutamic Acid Acamprosate 4-(1-Amino-1-Carboxy-Ethyl)-Benzoic Acid
Diseases
GWAS
Protein-Protein Interactions		21 interactors: DLG4 EPHA3 EPHA4 EPHB1 EPHB2 EPHB4 EPHB6 GRIP1 GRM1 GRM5 HOMER1 NCK2 PDZRN3 PECAM1 PICK1 PSEN1 PTPN13 RGS3 RHBDL2 SDCBP SRC	12 interactors: ADORA1 ADRBK1 EFNB2 GAPDH GPRASP1 GRASP HOMER1 HOMER2 ITPR1 OPTN PRKCA TUBB
Entrez ID		1948	2911
HPRD ID		02754	05129
Ensembl ID		ENSG00000125266	ENSG00000152822
Uniprot IDs		P52799	F8W805 Q13255 Q59HC2
PDB IDs		2HLE 2I85 2VSK 2VSM 2WO2 3GXU	3KS9
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Neuron Development Axon Guidance Neuron Differentiation Generation Of Neurons Neurogenesis Axonogenesis Cell Development Axon Development Neuron Projection Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cell Projection Organization Neuron Projection Morphogenesis Regulation Of Signaling Locomotion Cell Morphogenesis Involved In Differentiation Nervous System Development Movement Of Cell Or Subcellular Component Cell Projection Morphogenesis Cell Part Morphogenesis Dendritic Spine Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Cell Differentiation Response To External Stimulus Cell Morphogenesis System Development Cell Migration Signal Transduction Synaptic Transmission Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Dendritic Spine Morphogenesis Cell Motility Regulation Of MAPK Cascade Multicellular Organismal Development Regulation Of Phosphorylation Signaling Cell Communication Anatomical Structure Development Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Organization Regulation Of Synaptic Transmission Dendritic Spine Development Regulation Of Synaptic Plasticity Developmental Process Behavior	Defense Response Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Negative Regulation Of Striated Muscle Contraction Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Negative Regulation Of Signaling Positive Regulation Of Lipase Activity Regulation Of Signal Transduction Chemical Homeostasis Within A Tissue Behavioral Response To Cocaine Regulation Of Signaling Innate Immune Response Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Negative Regulation Of Muscle Contraction Regulation Of Muscle Contraction Negative Regulation Of Heart Contraction Epidermal Growth Factor Receptor Signaling Pathway Response To Stimulus Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Heart Contraction Cell Death Regulation Of Behavior Cellular Response To Stimulus Death Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of The Force Of Heart Contraction Negative Regulation Of Signal Transduction Signal Transduction Neurotrophin TRK Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Neurotrophin Signaling Pathway Multicellular Organismal Homeostasis Regulation Of Secretion Musculoskeletal Movement Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-threonine Phosphorylation Immune Response Muscle System Process Regulation Of Hormone Secretion Response To Cocaine Cell Surface Receptor Signaling Pathway Cell Communication Homeostatic Process Glutamate Receptor Signaling Pathway
Tagcloud ?		a2780 a2780mtp53 adamts1 affymetrix angiogenesis angiogenic angiopoietin arrays b4 confirmation constituents ecm efna3 endoglin ephrin exploratory fgf20 hypoxic integral ionizing metalloproteinase microenvironment mmp10 mtp53 tp53 u133a upregulated vegfa wttp53	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi
Tagcloud (Difference) ?		a2780 a2780mtp53 adamts1 affymetrix angiogenesis angiogenic angiopoietin arrays b4 confirmation constituents ecm efna3 endoglin ephrin exploratory fgf20 hypoxic integral ionizing metalloproteinase microenvironment mmp10 mtp53 tp53 u133a upregulated vegfa wttp53	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi
Tagcloud (Intersection) ?