EFNB2 and EPHA3

Number of citations of the paper that reports this interaction (PMID 9195962)
16

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		EFNB2	EPHA3
Gene Name		ephrin-B2	EPH receptor A3
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion	Extracellular Region Early Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Ephrin Receptor Binding	GPI-linked Ephrin Receptor Activity Protein Binding ATP Binding
	Biological Process	Lymph Vessel Development Cell Migration Involved In Sprouting Angiogenesis Cell Adhesion Cell-cell Signaling Axon Guidance Anatomical Structure Morphogenesis Organ Morphogenesis Negative Regulation Of Keratinocyte Proliferation Viral Process Ephrin Receptor Signaling Pathway Regulation Of Chemotaxis Positive Regulation Of Cardiac Muscle Cell Differentiation	Cell Adhesion Axon Guidance Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Signaling Pathway Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Retinoic Acid Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon
Pathways		EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS			Orofacial clefts ( 22863734)
Protein-Protein Interactions		21 interactors: DLG4 EPHA3 EPHA4 EPHB1 EPHB2 EPHB4 EPHB6 GRIP1 GRM1 GRM5 HOMER1 NCK2 PDZRN3 PECAM1 PICK1 PSEN1 PTPN13 RGS3 RHBDL2 SDCBP SRC	20 interactors: ABL1 ADAM10 CDKN2A CRK EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 FYN PIM1 RBM18 RUFY1 RUFY2 SRC SRPK1 STAT3 TP53
Entrez ID		1948	2042
HPRD ID		02754	01555
Ensembl ID		ENSG00000125266	ENSG00000044524
Uniprot IDs		P52799	C9JXA2 P29320 Q6P4R6
PDB IDs		2HLE 2I85 2VSK 2VSM 2WO2 3GXU	2GSF 2QO2 2QO7 2QO9 2QOB 2QOC 2QOD 2QOF 2QOI 2QOK 2QOL 2QON 2QOO 2QOQ 3DZQ 3FXX 3FY2 4G2F 4GK2 4GK3 4GK4
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Neuron Development Axon Guidance Neuron Differentiation Generation Of Neurons Neurogenesis Axonogenesis Cell Development Axon Development Neuron Projection Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cell Projection Organization Neuron Projection Morphogenesis Regulation Of Signaling Locomotion Cell Morphogenesis Involved In Differentiation Nervous System Development Movement Of Cell Or Subcellular Component Cell Projection Morphogenesis Cell Part Morphogenesis Dendritic Spine Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Cell Differentiation Response To External Stimulus Cell Morphogenesis System Development Cell Migration Signal Transduction Synaptic Transmission Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Dendritic Spine Morphogenesis Cell Motility Regulation Of MAPK Cascade Multicellular Organismal Development Regulation Of Phosphorylation Signaling Cell Communication Anatomical Structure Development Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Organization Regulation Of Synaptic Transmission Dendritic Spine Development Regulation Of Synaptic Plasticity Developmental Process Behavior	Ephrin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Differentiation Neuron Projection Development Cell Projection Morphogenesis Generation Of Neurons Cell Part Morphogenesis Neurogenesis Neuron Development Cell Development Cell Morphogenesis Movement Of Cell Or Subcellular Component Cell Projection Organization Locomotion Nervous System Development Response To External Stimulus Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Cell Differentiation Signal Transduction Developmental Process Regulation Of Cell Adhesion Signaling Cell Communication Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Phosphorylation Multicellular Organismal Development Regulation Of Cell-cell Adhesion Regulation Of Cellular Component Organization Anatomical Structure Development Regulation Of Cell Proliferation Regulation Of Protein Phosphorylation System Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Cell Cycle Positive Regulation Of Phosphorylation
Tagcloud ?		a2780 a2780mtp53 adamts1 affymetrix angiogenesis angiogenic angiopoietin arrays b4 confirmation constituents ecm efna3 endoglin ephrin exploratory fgf20 hypoxic integral ionizing metalloproteinase microenvironment mmp10 mtp53 tp53 u133a upregulated vegfa wttp53	arid2 asxl3 cdkn2a clonal clone dipyrimidine driver extension founding geographic hypermutator lacked mel9 melanoma mll2 nras phosphatases ptprb ptprd ptprt rb1 signature strikingly subclonal subclones suppressors transitions truncation wgs
Tagcloud (Difference) ?		a2780 a2780mtp53 adamts1 affymetrix angiogenesis angiogenic angiopoietin arrays b4 confirmation constituents ecm efna3 endoglin ephrin exploratory fgf20 hypoxic integral ionizing metalloproteinase microenvironment mmp10 mtp53 tp53 u133a upregulated vegfa wttp53	arid2 asxl3 cdkn2a clonal clone dipyrimidine driver extension founding geographic hypermutator lacked mel9 melanoma mll2 nras phosphatases ptprb ptprd ptprt rb1 signature strikingly subclonal subclones suppressors transitions truncation wgs
Tagcloud (Intersection) ?