EFNB2 and DLG4

Number of citations of the paper that reports this interaction (PMID 15458844)
39

Data Source:
HPRD (two hybrid)

		EFNB2	DLG4
Gene Name		ephrin-B2	discs, large homolog 4 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion	Cytoplasm Endoplasmic Reticulum Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Cell Junction Endocytic Vesicle Membrane Cortical Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Dendrite Cytoplasm Dendritic Spine Juxtaparanode Region Of Axon Cerebellar Mossy Fiber Neuron Projection Terminus Neuron Spine Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	Protein Binding Ephrin Receptor Binding	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Protein Phosphatase Binding PDZ Domain Binding Beta-1 Adrenergic Receptor Binding D1 Dopamine Receptor Binding P2Y1 Nucleotide Receptor Binding Protein Complex Binding Acetylcholine Receptor Binding Ionotropic Glutamate Receptor Binding Scaffold Protein Binding
	Biological Process	Lymph Vessel Development Cell Migration Involved In Sprouting Angiogenesis Cell Adhesion Cell-cell Signaling Axon Guidance Anatomical Structure Morphogenesis Organ Morphogenesis Negative Regulation Of Keratinocyte Proliferation Viral Process Ephrin Receptor Signaling Pathway Regulation Of Chemotaxis Positive Regulation Of Cardiac Muscle Cell Differentiation	Negative Regulation Of Receptor Internalization Protein Complex Assembly Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Nervous System Development Axon Guidance Learning Synaptic Vesicle Maturation Social Behavior Protein Localization To Synapse Locomotory Exploration Behavior Establishment Of Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance Dendritic Spine Morphogenesis Vocalization Behavior Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Receptor Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Grooming Behavior
Pathways		EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	Axon guidance L1CAM interactions Activation of Kainate Receptors upon glutamate binding CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII NrCAM interactions Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Activation of Ca-permeable Kainate Receptor Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Liver enzyme levels (alkaline phosphatase) ( 22001757)
Protein-Protein Interactions		21 interactors: DLG4 EPHA3 EPHA4 EPHB1 EPHB2 EPHB4 EPHB6 GRIP1 GRM1 GRM5 HOMER1 NCK2 PDZRN3 PECAM1 PICK1 PSEN1 PTPN13 RGS3 RHBDL2 SDCBP SRC	104 interactors: ACTN2 ADRB1 AKAP5 ARHGAP32 ASIC3 ATP2B2 ATP2B4 BAI1 BEGAIN CACNG2 CASK CD46 CIT CNKSR2 CRIPT DLG2 DLG3 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DYNLL1 EFNB2 ERBB2 ERBB2IP ERBB4 EXOC4 FYN FZD1 FZD2 FZD4 FZD7 GDA GLS2 GNG13 GRASP GRIK1 GRIK2 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GUCY1A2 HGS HTR2A HTR2C HTT IL13RA1 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCND2 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF13B KIF1B LIN7A LIN7B LPHN1 LRFN1 LRP1 LRP2 LRP8 LRRC1 LYN MAP1A MAP3K10 MAPK12 MDM2 NCKIPSD NDOR1 NLGN1 NLGN2 NLGN3 NLGN4X NOS1 PCDH10 PRKCA PTK2B PTPRG SCN5A SEMA4B SEMA4C SEMA4F SEMA4G SHANK1 SHANK2 SIPA1L1 SPRR2A SRC SYNGAP1 TANC1 WNT3A YES1 ZDHHC17
Entrez ID		1948	1742
HPRD ID		02754	04199
Ensembl ID		ENSG00000125266	ENSG00000132535
Uniprot IDs		P52799	B7Z647 B9EGL1 P78352
PDB IDs		2HLE 2I85 2VSK 2VSM 2WO2 3GXU	1KEF 3I4W 3K82 3ZRT
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Neuron Development Axon Guidance Neuron Differentiation Generation Of Neurons Neurogenesis Axonogenesis Cell Development Axon Development Neuron Projection Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cell Projection Organization Neuron Projection Morphogenesis Regulation Of Signaling Locomotion Cell Morphogenesis Involved In Differentiation Nervous System Development Movement Of Cell Or Subcellular Component Cell Projection Morphogenesis Cell Part Morphogenesis Dendritic Spine Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Cell Differentiation Response To External Stimulus Cell Morphogenesis System Development Cell Migration Signal Transduction Synaptic Transmission Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Dendritic Spine Morphogenesis Cell Motility Regulation Of MAPK Cascade Multicellular Organismal Development Regulation Of Phosphorylation Signaling Cell Communication Anatomical Structure Development Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Organization Regulation Of Synaptic Transmission Dendritic Spine Development Regulation Of Synaptic Plasticity Developmental Process Behavior	Cell-cell Signaling Synaptic Transmission Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Ion Transmembrane Transport Membrane Depolarization Nervous System Development Regulation Of Postsynaptic Membrane Potential Regulation Of Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Neurological System Process Neuron-neuron Synaptic Transmission Glutamate Receptor Signaling Pathway Signal Transduction Metal Ion Transport Synaptic Transmission, Glutamatergic Neurogenesis Response To Stimulus Ion Transport Generation Of Neurons Cellular Response To Stimulus Transport System Development Cation Transport Cell Surface Receptor Signaling Pathway Single-organism Behavior Sensory Perception Of Pain Behavior Neuron Differentiation Regulation Of Signal Transduction Response To Abiotic Stimulus Ion Transmembrane Transport Regulation Of Cellular Localization Anatomical Structure Development Regulation Of Cellular Process Membrane Hyperpolarization Cell Differentiation Cation Transmembrane Transport Multicellular Organismal Development Developmental Process Regulation Of Phosphorus Metabolic Process Learning Response To External Stimulus Cellular Process Neuron Development Positive Regulation Of Signal Transduction
Tagcloud ?		a2780 a2780mtp53 adamts1 affymetrix angiogenesis angiogenic angiopoietin arrays b4 confirmation constituents ecm efna3 endoglin ephrin exploratory fgf20 hypoxic integral ionizing metalloproteinase microenvironment mmp10 mtp53 tp53 u133a upregulated vegfa wttp53	6g1 alleviated amyloid ca1 counteract densities distant fibrillar immunohistochemically immunotherapy oligomer oligomeric oligomers plaque plaques presynapses psd95 quantified reservoirs sequestering suffices synapse synapses synapsin synaptotoxic tg2576 unchanged unspecific vicinity
Tagcloud (Difference) ?		a2780 a2780mtp53 adamts1 affymetrix angiogenesis angiogenic angiopoietin arrays b4 confirmation constituents ecm efna3 endoglin ephrin exploratory fgf20 hypoxic integral ionizing metalloproteinase microenvironment mmp10 mtp53 tp53 u133a upregulated vegfa wttp53	6g1 alleviated amyloid ca1 counteract densities distant fibrillar immunohistochemically immunotherapy oligomer oligomeric oligomers plaque plaques presynapses psd95 quantified reservoirs sequestering suffices synapse synapses synapsin synaptotoxic tg2576 unchanged unspecific vicinity
Tagcloud (Intersection) ?