LPAR1 and SLC9A3R2

Number of citations of the paper that reports this interaction (PMID 16203867)
43

Data Source:
HPRD (in vitro)

		LPAR1	SLC9A3R2
Gene Name		lysophosphatidic acid receptor 1	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle Dendritic Spine Dendritic Shaft	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Endomembrane System Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Alpha-subunit Binding G-protein Coupled Receptor Activity Protein Binding Phospholipid Binding PDZ Domain Binding Lysophosphatidic Acid Receptor Activity	Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Phosphatase Binding
	Biological Process	Activation Of MAPK Activity G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Neuron Projection Development Bleb Assembly Positive Regulation Of Rho Protein Signal Transduction Myelination Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Dendritic Spine Development Cellular Response To Oxygen Levels Positive Regulation Of Smooth Muscle Cell Chemotaxis	Protein Complex Assembly Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Corneal structure ( 23291589) Height ( 20881960)
Protein-Protein Interactions		5 interactors: ARHGEF11 ARHGEF12 GNAI3 KRAS SLC9A3R2	35 interactors: ABCC4 ACTN4 ADORA2B ADRB2 ATP2B2 CFTR EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDPK1 PDZK1 PIK3CA PLCB3 PODXL PRKACA PTEN PTH1R RDX SGK1 SGK3 SIAH1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAZ TBC1D10A WWTR1
Entrez ID		1902	9351
HPRD ID		03790	05946
Ensembl ID		ENSG00000198121	ENSG00000065054
Uniprot IDs		Q5VZX0 Q92633	Q15599
PDB IDs			2D11 2HE4 2OCS
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Axon Guidance Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Axonogenesis Axon Development Cellular Response To Growth Factor Stimulus Regulation Of Intracellular Signal Transduction Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Response To Growth Factor Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Small GTPase Mediated Signal Transduction Neuron Projection Morphogenesis Regulation Of Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Small GTPase Mediated Signal Transduction Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Catalytic Activity Enzyme Linked Receptor Protein Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Neuron Development Cell Morphogenesis Ras Protein Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Neuron Differentiation Positive Regulation Of Rho GTPase Activity Cell Projection Organization G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Regulation Of Rho GTPase Activity Locomotion Cell Surface Receptor Signaling Pathway Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Catalytic Activity Regulation Of Cell Death Generation Of Neurons Blood Coagulation Neurogenesis Cell Division	Regulation Of Protein Kinase Activity Ion Homeostasis Transmembrane Transport Regulation Of Kinase Activity Regulation Of Ion Transport Positive Regulation Of Ion Transport Regulation Of Protein Phosphorylation Homeostatic Process Positive Regulation Of Transport Ion Transport Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Phosphorylation Ion Transmembrane Transport Cellular Cation Homeostasis Organic Anion Transport Cellular Ion Homeostasis Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Positive Regulation Of Protein Kinase Activity Blood Circulation Positive Regulation Of Cellular Protein Metabolic Process Anion Transport Platelet Activation Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Transport Positive Regulation Of Protein Phosphorylation Sodium-independent Organic Anion Transport Carnitine Transport Cellular Chemical Homeostasis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Monocarboxylic Acid Transport Sperm Capacitation Anion Transmembrane Transport Regulation Of Cellular Component Organization Sodium Ion Transport Inorganic Anion Transport Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Ion Transmembrane Transport Blood Coagulation Hemostasis Activation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Quaternary Ammonium Group Transport Positive Regulation Of Cytosolic Calcium Ion Concentration
Tagcloud ?		231t 4t1 debio dormancy edg2 h1 hairpinned hereafter histologic indicative inverse ki67 lpa1 lungs lysophosphatidic mb mda metastases metastasis nm23 nme1 nonmetastatic perk section shrna spontaneous tailed variance vehicle
Tagcloud (Difference) ?		231t 4t1 debio dormancy edg2 h1 hairpinned hereafter histologic indicative inverse ki67 lpa1 lungs lysophosphatidic mb mda metastases metastasis nm23 nme1 nonmetastatic perk section shrna spontaneous tailed variance vehicle
Tagcloud (Intersection) ?