LPAR1 and ARHGEF11

Number of citations of the paper that reports this interaction (PubMedID 15755723)
0

Data Source:
HPRD (in vitro, in vivo)

		LPAR1	ARHGEF11
Description		lysophosphatidic acid receptor 1	Rho guanine nucleotide exchange factor 11
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GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Cell Surface Membrane Endocytic Vesicle Presynaptic Membrane Neuronal Cell Body Dendritic Spine Dendritic Shaft Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Protein Binding Phospholipid Binding Lipid Binding PDZ Domain Binding Lysophosphatidic Acid Binding Lysophosphatidic Acid Receptor Activity	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cell Shape Negative Regulation Of Neuron Projection Development Oligodendrocyte Development Cerebellum Development Optic Nerve Development Neurogenesis Corpus Callosum Development Bleb Assembly Positive Regulation Of Rho Protein Signal Transduction Myelination Golgi To Plasma Membrane Protein Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Cilium Assembly Positive Regulation Of Stress Fiber Assembly Cell Chemotaxis Regulation Of Vesicle-mediated Transport Positive Regulation Of Dendritic Spine Development Protein Localization To Cilium Cellular Response To Oxygen Levels Positive Regulation Of Smooth Muscle Cell Chemotaxis Regulation Of Synaptic Vesicle Cycle Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Cilium Assembly Cellular Response To 1-oleoyl-sn-glycerol 3-phosphate	Regulation Of Cell Growth Striated Muscle Contraction G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of DNA-templated Transcription Regulation Of Small GTPase Mediated Signal Transduction
Pathways		G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors	NRAGE signals death through JNK G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Birth weight ( 27680694 31043758) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 31798171 30894546 29760442) Corneal structure ( 23291589) Cortical thickness ( 32963231) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Height ( 31562340 25282103 20881960) Monocyte count ( 28031487 28193307 29403010 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Offspring birth weight ( 31043758) Post bronchodilator FEV1 in COPD ( 26634245) Pursuit maintenance gain ( 29064472) Sum eosinophil basophil counts ( 27863252) White blood cell count (monocyte) ( 28158719) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Height ( 31562340) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		7 interacting genes: ARHGEF11 ARHGEF12 DRD2 GIPC1 GNAI3 KRAS NHERF2	16 interacting genes: ABCA1 CDC42 GNA12 GNA13 KLHL20 LPAR1 LPAR2 MAP1A MAP1B PLXNB1 PLXNB2 PLXNB3 PTPRF RHOA RPS6KA1 SLC1A6
Entrez ID		1902	9826
HPRD ID		03790	09302
Ensembl ID		ENSG00000198121	ENSG00000132694
Uniprot IDs		Q5VZX0 Q6GPG7 Q92633	A0AAQ5BIK5 O15085
PDB IDs		4Z34 4Z35 4Z36 7TD0 7TD1 7TD2 7YU3 7YU4 7YU5 7YU6 7YU7 7YU8 9IZF 9IZG 9IZH 9J5V	1HTJ 1XCG 2DLS 3KZ1 3T06 5E6P 5JHG 5JHH 5TYT
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding Regulation Of Synaptic Transmission, GABAergic Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Protein-membrane Adaptor Activity Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cytokinesis Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Visual Learning Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Neuronal Synaptic Plasticity Visual Behavior Rho Protein Signal Transduction Signaling Receptor Binding GDP Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cytokinesis Positive Regulation Of Cell Division Associative Learning Modulation Of Chemical Synaptic Transmission G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Type 2 Metabotropic Glutamate Receptor Binding Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway GMP Binding Forebrain Astrocyte Development Type 3 Metabotropic Glutamate Receptor Binding Signal Transduction Membrane Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Golgi Membrane Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Dopamine Secretion Dendritic Spine Response To Isolation Stress Learning Morphogenesis Of A Branching Structure Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression	Regulation Of Cell Shape Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Semaphorin-plexin Signaling Pathway Regulation Of Neuron Projection Development Regulation Of Cell Morphogenesis Cell Junction Assembly Semaphorin Receptor Activity Semaphorin Receptor Complex Positive Regulation Of Cellular Component Organization Regulation Of Biological Quality G Protein Activity Glutamatergic Synapse Neuronal Cell Body Positive Regulation Of Cell Projection Organization D5 Dopamine Receptor Binding Positive Regulation Of Axonogenesis Regulation Of Rho Protein Signal Transduction Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell Migration Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Regulation Of Developmental Process Regulation Of Cell Motility Positive Regulation Of Rho Protein Signal Transduction Synapse Assembly Regulation Of Locomotion Cell Junction Organization Lysophosphatidic Acid Receptor Activity Regulation Of Cytoskeleton Organization Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Anatomical Structure Morphogenesis Regulation Of Axonogenesis Membrane Invagination Cell Migration Rho-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Supramolecular Fiber Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Ossification Involved In Bone Maturation Rho Protein Signal Transduction Cell Motility Regulation Of Intracellular Signal Transduction Endocytic Vesicle
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