LPAR1 and GIPC1

Number of citations of the paper that reports this interaction (PubMedID 23145131)
53

Data Source:
BioGRID (affinity chromatography technology, pull down)

		LPAR1	GIPC1
Description		lysophosphatidic acid receptor 1	GIPC PDZ domain containing family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Cell Surface Membrane Endocytic Vesicle Presynaptic Membrane Neuronal Cell Body Dendritic Spine Dendritic Shaft Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Cytosol Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Cytoplasmic Vesicle Dendritic Spine Dendritic Shaft Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Protein Binding Phospholipid Binding Lipid Binding PDZ Domain Binding Lysophosphatidic Acid Binding Lysophosphatidic Acid Receptor Activity	Actin Binding Signaling Receptor Binding Protein Binding Myosin Binding Identical Protein Binding Cadherin Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cell Shape Negative Regulation Of Neuron Projection Development Oligodendrocyte Development Cerebellum Development Optic Nerve Development Neurogenesis Corpus Callosum Development Bleb Assembly Positive Regulation Of Rho Protein Signal Transduction Myelination Golgi To Plasma Membrane Protein Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Cilium Assembly Positive Regulation Of Stress Fiber Assembly Cell Chemotaxis Regulation Of Vesicle-mediated Transport Positive Regulation Of Dendritic Spine Development Protein Localization To Cilium Cellular Response To Oxygen Levels Positive Regulation Of Smooth Muscle Cell Chemotaxis Regulation Of Synaptic Vesicle Cycle Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Cilium Assembly Cellular Response To 1-oleoyl-sn-glycerol 3-phosphate	Protein Targeting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Positive Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Cellular Response To Interleukin-7 Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors	FGFR1b ligand binding and activation FGFR1c ligand binding and activation TGFBR3 regulates TGF-beta signaling TGFBR3 regulates FGF2 signaling
Drugs
Diseases
GWAS		Birth weight ( 27680694 31043758) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 31798171 30894546 29760442) Corneal structure ( 23291589) Cortical thickness ( 32963231) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Height ( 31562340 25282103 20881960) Monocyte count ( 28031487 28193307 29403010 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Offspring birth weight ( 31043758) Post bronchodilator FEV1 in COPD ( 26634245) Pursuit maintenance gain ( 29064472) Sum eosinophil basophil counts ( 27863252) White blood cell count (monocyte) ( 28158719) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Femur bone mineral density x serum urate levels interaction ( 34046847) Kidney stones ( 31729369)
Interacting Genes		7 interacting genes: ARHGEF11 ARHGEF12 DRD2 GIPC1 GNAI3 KRAS NHERF2	37 interacting genes: ACTN1 ADRB1 CARD10 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KCNJ6 KIF1B LHCGR LPAR1 LPAR2 LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 PLEKHA2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SLC2A1 TGFBR3 TPBG TYRP1 VANGL2 ZFPM1 ZNF408
Entrez ID		1902	10755
HPRD ID		03790	05462
Ensembl ID		ENSG00000198121	ENSG00000123159
Uniprot IDs		Q5VZX0 Q6GPG7 Q92633	A8K2I7 O14908
PDB IDs		4Z34 4Z35 4Z36 7TD0 7TD1 7TD2 7YU3 7YU4 7YU5 7YU6 7YU7 7YU8 9IZF 9IZG 9IZH 9J5V
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding Regulation Of Synaptic Transmission, GABAergic Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Protein-membrane Adaptor Activity Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cytokinesis Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Visual Learning Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Neuronal Synaptic Plasticity Visual Behavior Rho Protein Signal Transduction Signaling Receptor Binding GDP Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cytokinesis Positive Regulation Of Cell Division Associative Learning Modulation Of Chemical Synaptic Transmission G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Type 2 Metabotropic Glutamate Receptor Binding Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway GMP Binding Forebrain Astrocyte Development Type 3 Metabotropic Glutamate Receptor Binding Signal Transduction Membrane Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Golgi Membrane Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Dopamine Secretion Dendritic Spine Response To Isolation Stress Learning Morphogenesis Of A Branching Structure Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression	Plasma Membrane Glutamatergic Synapse Membrane Cell Migration Regulation Of Locomotion Regulation Of Signal Transduction Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Migration Receptor Complex Positive Regulation Of Signal Transduction Axon Regulation Of Cell Motility Cell Motility PDZ Domain Binding Cell Projection Organization Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Anatomical Structure Formation Involved In Morphogenesis Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Nervous System Development Developmental Process Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Nervous System Development Positive Regulation Of Cellular Component Organization Endocytic Vesicle Positive Regulation Of Locomotion Dendrite Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Apoptotic Process Neural Tube Closure Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death Tube Closure Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Insulin-like Growth Factor I Binding Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility
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