ERP44 and ITPR1

Number of citations of the paper that reports this interaction (PubMedID 15652484)
0

Data Source:
HPRD (in vivo, in vitro)

		ERP44	ITPR1
Description		endoplasmic reticulum protein 44	inositol 1,4,5-trisphosphate receptor type 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Cell Surface Specific Granule Lumen Extracellular Exosome	Nuclear Envelope Nuclear Inner Membrane Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Calcineurin Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Secretory Granule Membrane Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane Cytoplasmic Vesicle Protein-containing Complex Synapse Perinuclear Region Of Cytoplasm Schaffer Collateral - CA1 Synapse
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding	Nucleotide Binding Monoatomic Ion Channel Activity Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding Calcium Ion Transmembrane Transporter Activity Intracellularly Gated Calcium Channel Activity Calcium Channel Inhibitor Activity Protein Domain Specific Binding Phosphatidylinositol Binding Protein Homodimerization Activity Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels
	Biological Process	Protein Folding Response To Unfolded Protein Glycoprotein Metabolic Process Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis	Cell Morphogenesis Response To Hypoxia Monoatomic Ion Transport Calcium Ion Transport Apoptotic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Single Fertilization Post-embryonic Development Regulation Of Autophagy Calcium-mediated Signaling Positive Regulation Of Insulin Secretion Endoplasmic Reticulum Calcium Ion Homeostasis Monoatomic Ion Transmembrane Transport Calcium Import Into The Mitochondrion Epithelial Fluid Transport Positive Regulation Of Apoptotic Process Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Ligand-gated Ion Channel Signaling Pathway
Pathways		Neutrophil degranulation	PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway cGMP effects Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Caffeine 1D-myo-inositol 1,4,5-trisphosphate Glycerin
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Preeclampsia ( 23551011)	Airflow obstruction ( 22837378) Breast cancer ( 23535729) Calcium levels ( 29403010) Diabetic kidney disease ( 26305897) Femur bone mineral density x serum urate levels interaction ( 34046847) Gamma glutamyl transferase levels ( 29403010 33339817) Hand grip strength ( 29691431) HDL cholesterol levels in HIV infection ( 33109212) Hematocrit ( 32888494) Lead levels ( 26025379) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Obesity-related traits ( 23251661) Systolic blood pressure ( 26969751) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels ( 32154731 32203549) Uterine fibroids ( 30194396) Weight ( 28552196) Western dietary pattern ( 28644415)
Interacting Genes		3 interacting genes: ERO1A ERO1B ITPR1	32 interacting genes: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 BECN1 BRCA1 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERBB2 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 IRAG1 ITPR3 ITPRIP LYN PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4
Entrez ID		23071	3708
HPRD ID		10290	00925
Ensembl ID		ENSG00000023318	ENSG00000150995
Uniprot IDs		A0A384MEE7 Q9BS26	B4DER3 B4DGH1 Q14643 Q59H91
PDB IDs		2R2J 5GU6 5GU7 5HQP 5XWM
Enriched GO Terms of Interacting Partners?		Calcineurin Complex Thiol Oxidase Activity Protein Folding In Endoplasmic Reticulum Protein-disulfide Reductase Activity Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis FAD Binding Endoplasmic Reticulum Membrane Sphingolipid Floppase Activity Release Of Sequestered Calcium Ion Into Cytosol Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels Negative Regulation Of Sequestering Of Calcium Ion Response To Vitamin B3 Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity Cytoskeletal Calyx Endoplasmic Reticulum-Golgi Intermediate Compartment Organization	Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Intracellular Signaling Cassette Regulation Of Calcium Ion Transport Intracellular Signal Transduction Signal Transduction G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Response To Metal Ion Regulation Of Transport Regulation Of Cell Communication Regulation Of Cellular Localization Regulation Of Signal Transduction Regulation Of Signaling G Protein-coupled Glutamate Receptor Binding Regulation Of Calcium Ion Transmembrane Transport Regulation Of Muscle System Process Glutamate Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Protein Phosphorylation Response To Calcium Ion Calcium Ion Transport Phosphorylation Regulation Of Monoatomic Cation Transmembrane Transport Plasma Membrane Negative Regulation Of Signal Transduction Glutamatergic Synapse Regulation Of System Process Negative Regulation Of Multicellular Organismal Process Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Hydrogen Peroxide Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Cell Communication Positive Regulation Of Signaling Inositol 1,4,5 Trisphosphate Binding Calcium Ion Transmembrane Transport Regulation Of Store-operated Calcium Entry Regulation Of Cell Activation Negative Regulation Of Apoptotic Process Lymphocyte Proliferation Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Calcium Ion Homeostasis Mononuclear Cell Proliferation Protein Kinase Activity
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