CSTB

Description		cystatin B
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Extracellular Matrix Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protease Binding RNA Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Adult Locomotory Behavior Negative Regulation Of Proteolysis
Pathways		Neutrophil degranulation
Drugs		Cupric Chloride
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Blood protein levels in cardiovascular risk ( 28369058)
Novel Interacting Genes		3 novel interacting genes: COL6A1 ERG RUNX1
Interacting Genes		8 interacting genes: CST3 CTSB CTSD CTSH CTSL ECT2 RAD21 SPRY2
Entrez ID		1476
HPRD ID		03091
Ensembl ID		ENSG00000160213
Uniprot IDs		P04080 Q76LA1
PDB IDs		1STF 2OCT 4N6V
Enriched GO Terms of Interacting Partners?		Cysteine-type Endopeptidase Activity Cellular Response To Thyroid Hormone Stimulus Response To Thyroid Hormone Ficolin-1-rich Granule Lumen Extracellular Matrix Endolysosome Lumen Tertiary Granule Lumen Lysosome Regulation Of Extracellular Matrix Organization Collagen Binding Collagen Metabolic Process Endopeptidase Activity Proteoglycan Binding Antigen Processing And Presentation Cysteine-type Peptidase Activity Regulation Of Apoptotic Process Lung Morphogenesis Peptidase Activity Regulation Of Programmed Cell Death Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Zymogen Activation Collagen Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Regulation Of Collagen Metabolic Process Antigen Processing And Presentation Of Exogenous Antigen Tissue Regeneration Response To Polyamine Macromolecule Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process ERK1 And ERK2 Cascade HLA-A Specific Activating MHC Class I Receptor Activity Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Cellular Developmental Process Antigen Processing And Presentation Of Peptide Antigen Extracellular Exosome Extracellular Region Regulation Of Tissue Remodeling Multicellular Organismal Locomotion Negative Regulation Of Blood Vessel Remodeling Cellular Response To Hormone Stimulus Aspartic-type Peptidase Activity Kininogen Binding Enkephalin Processing Lung Growth Extracellular Space Lysosomal Lumen
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