NPC2 and DHDDS

Number of citations of the paper that reports this interaction (PMID 15110773)
4

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		NPC2	DHDDS
Gene Name		Niemann-Pick disease, type C2	dehydrodolichyl diphosphate synthase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Endoplasmic Reticulum Extracellular Vesicular Exosome	Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Cholesterol Binding Enzyme Binding	Protein Binding Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups
	Biological Process	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Cholesterol Homeostasis Glycolipid Transport	Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Synthesis of Dolichyl-phosphate Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: BARD1 BRCA1 DHDDS ECT2 LIG4 PAXIP1 USP4	3 interactors: LOX ND1 NPC2
Entrez ID		10577	79947
HPRD ID		03008	12183
Ensembl ID		ENSG00000119655	ENSG00000117682
Uniprot IDs		E7EMS2 P61916	Q86SQ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Ionizing Radiation Protein K6-linked Ubiquitination Response To Radiation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone Acetylation DNA Repair Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Cellular Response To Stress Regulation Of Protein Ubiquitination DNA Recombination Positive Regulation Of Histone Methylation Cellular Response To DNA Damage Stimulus Regulation Of Histone Acetylation Regulation Of Histone Methylation DNA Metabolic Process Regulation Of Protein Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Histone Modification Positive Regulation Of Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H3-K36 Methylation DNA Ligation Involved In DNA Recombination Positive Regulation Of Histone H4-K16 Acetylation Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of Apoptotic Process Signal Transduction By P53 Class Mediator Regulation Of Cell Death Regulation Of Histone Modification Negative Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone H3-K9 Acetylation Cellular Response To Metal Ion Positive Regulation Of Protein Ubiquitination Cellular Response To Inorganic Substance Cellular Protein Modification Process Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Response To Stress Regulation Of Microtubule-based Process Protein Polyubiquitination Regulation Of Cellular Protein Metabolic Process Dolichyl Diphosphate Biosynthetic Process Cellular Response To Indole-3-methanol Regulation Of Chromosome Organization	Regulation Of Isoprenoid Metabolic Process Elastic Fiber Assembly Intracellular Cholesterol Transport Intracellular Sterol Transport Glycolipid Transport Extracellular Matrix Assembly
Tagcloud ?		9years assume autosomal carriers connection deterioration distinctive expand gaucher gba gd glucocerebrosidase heterozygous lysosomal mentioned miglustat mind neurodegenerative niemann npc1 pick psen1 psen2 recessive sometimes storage trying worth	agglutinin appearance cone degeneration dehydrodolichol diphosphate enzymatic injected insufficient knocked missing mo modeling morpholino oligonucleotides outer peanut photoreceptor pigmentosa pna recessive respond retinal retinas retinitis rp segments visual zebrafish
Tagcloud (Difference) ?		9years assume autosomal carriers connection deterioration distinctive expand gaucher gba gd glucocerebrosidase heterozygous lysosomal mentioned miglustat mind neurodegenerative niemann npc1 pick psen1 psen2 sometimes storage trying worth	agglutinin appearance cone degeneration dehydrodolichol diphosphate enzymatic injected insufficient knocked missing mo modeling morpholino oligonucleotides outer peanut photoreceptor pigmentosa pna respond retinal retinas retinitis rp segments visual zebrafish
Tagcloud (Intersection) ?		recessive