NPC2 and USP4

Number of citations of the paper that reports this interaction (PMID 23022198)
1

Data Source:
BioGRID (two hybrid)

		NPC2	USP4
Gene Name		Niemann-Pick disease, type C2	ubiquitin specific peptidase 4 (proto-oncogene)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Endoplasmic Reticulum Extracellular Vesicular Exosome	Nucleus Cytoplasm Lysosome Plasma Membrane
	Molecular Function	Protein Binding Cholesterol Binding Enzyme Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Adenosine Receptor Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Cholesterol Homeostasis Glycolipid Transport	Spliceosomal Tri-snRNP Complex Assembly Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Cell Surface Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		7 interactors: BARD1 BRCA1 DHDDS ECT2 LIG4 PAXIP1 USP4	46 interactors: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BRAP CDKN1A FAM96B HUWE1 IGKV2D-29 LAMA5 LGALS1 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBL1 RBL2 RCC1 SART3 SMN1 TCF4 TGFBR1 TK1 TP53BP2 TRAF2 TRAF6 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28
Entrez ID		10577	7375
HPRD ID		03008	04598
Ensembl ID		ENSG00000119655	ENSG00000114316
Uniprot IDs		E7EMS2 P61916	Q08AK7 Q13107
PDB IDs			2Y6E
Enriched GO Terms of Interacting Partners?		Response To Ionizing Radiation Protein K6-linked Ubiquitination Response To Radiation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone Acetylation DNA Repair Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Cellular Response To Stress Regulation Of Protein Ubiquitination DNA Recombination Positive Regulation Of Histone Methylation Cellular Response To DNA Damage Stimulus Regulation Of Histone Acetylation Regulation Of Histone Methylation DNA Metabolic Process Regulation Of Protein Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Histone Modification Positive Regulation Of Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H3-K36 Methylation DNA Ligation Involved In DNA Recombination Positive Regulation Of Histone H4-K16 Acetylation Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of Apoptotic Process Signal Transduction By P53 Class Mediator Regulation Of Cell Death Regulation Of Histone Modification Negative Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone H3-K9 Acetylation Cellular Response To Metal Ion Positive Regulation Of Protein Ubiquitination Cellular Response To Inorganic Substance Cellular Protein Modification Process Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Response To Stress Regulation Of Microtubule-based Process Protein Polyubiquitination Regulation Of Cellular Protein Metabolic Process Dolichyl Diphosphate Biosynthetic Process Cellular Response To Indole-3-methanol Regulation Of Chromosome Organization	G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Apoptotic Process Cell Cycle Response To Stress Programmed Cell Death Cell Death Death Response To Stimulus Protein Polyubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle Protein Ubiquitination Mitotic Cell Cycle Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Immune System Process Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Cell Cycle Process Regulation Of Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Proteolysis Regulation Of Lipid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Transferase Activity Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Catalytic Activity Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Intracellular Signal Transduction Negative Regulation Of Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cell Cycle Checkpoint Cellular Response To Stimulus Mitotic G1 DNA Damage Checkpoint Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		9years assume autosomal carriers connection deterioration distinctive expand gaucher gba gd glucocerebrosidase heterozygous lysosomal mentioned miglustat mind neurodegenerative niemann npc1 pick psen1 psen2 recessive sometimes storage trying worth	1beta adaptor associates deubiquitinase deubiquitinates deubiquitination ectopic ikappabalpha importantly incompletely insight interact interacts kappab kappabalpha negatively nf polyubiquitination protease reporter signalling tnfalpha traf traf2 traf3 traf6 ubiquitin uncovers
Tagcloud (Difference) ?		9years assume autosomal carriers connection deterioration distinctive expand gaucher gba gd glucocerebrosidase heterozygous lysosomal mentioned miglustat mind neurodegenerative niemann npc1 pick psen1 psen2 recessive sometimes storage trying worth	1beta adaptor associates deubiquitinase deubiquitinates deubiquitination ectopic ikappabalpha importantly incompletely insight interact interacts kappab kappabalpha negatively nf polyubiquitination protease reporter signalling tnfalpha traf traf2 traf3 traf6 ubiquitin uncovers
Tagcloud (Intersection) ?