VANGL2 and PDZRN3

Number of citations of the paper that reports this interaction (PubMedID 23722234)
86

Data Source:
BioGRID (two hybrid)

		VANGL2	PDZRN3
Description		VANGL planar cell polarity protein 2	PDZ domain containing ring finger 3
Image
GO Annotations	Cellular Component	Stress Fiber Plasma Membrane Cell-cell Junction Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Cell Pole Cell Periphery Apical Cytoplasm Postsynaptic Density Membrane Glutamatergic Synapse	Cytoplasm Neuromuscular Junction Synapse
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development Heart Looping Membranous Septum Morphogenesis Muscular Septum Morphogenesis Rho Protein Signal Transduction Anterior/posterior Pattern Specification Heparan Sulfate Proteoglycan Biosynthetic Process Convergent Extension Involved In Neural Plate Elongation Regulation Of Wnt Signaling Pathway Glomerulus Development Regulation Of Actin Cytoskeleton Organization Somatic Stem Cell Population Maintenance Non-canonical Wnt Signaling Pathway Cell Migration Involved In Kidney Development Post-anal Tail Morphogenesis Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Wound Healing Apical Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Somatic Stem Cell Division Establishment Of Body Hair Planar Orientation Digestive Tract Morphogenesis Convergent Extension Involved In Axis Elongation Convergent Extension Involved In Organogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Inner Ear Receptor Cell Development Inner Ear Receptor Cell Stereocilium Organization Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Lateral Sprouting Involved In Lung Morphogenesis Kidney Morphogenesis Cochlea Development Cochlea Morphogenesis Regulation Of Establishment Of Planar Polarity Establishment Of Planar Polarity Involved In Neural Tube Closure Non-motile Cilium Assembly Regulation Of Synapse Pruning	Neuromuscular Junction Development Protein Ubiquitination
Pathways		PCP/CE pathway Asymmetric localization of PCP proteins RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive performance ( 19734545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Left-handedness ( 32989287) Multiple sclerosis ( 24076602 31604244) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469)	Dialysis-related mortality ( 21546767) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Mercury levels ( 26025379) Mitochondrial DNA copy number (white blood cells) ( 30704525) PR interval ( 30046033 30679814 32439900)
Interacting Genes		27 interacting genes: AP1M1 ARFRP1 ARHGEF12 DLG2 DLG4 DVL1 GIPC1 KBTBD7 LIN7A LRRC7 MAGI2 MAGI3 MAST1 MAST2 MPDZ PDZRN3 PTPN13 PTPN4 SCRIB SNTA1 SNTB1 SNTG1 SNTG2 SNX27 SQSTM1 SYNJ2BP VCP	8 interacting genes: BMPR2 EFNB2 LNX1 LNX2 RPS6KA1 SLC5A8 UBE2D2 VANGL2
Entrez ID		57216	23024
HPRD ID		02758	15115
Ensembl ID		ENSG00000162738	ENSG00000121440
Uniprot IDs		A8K4L6 Q9ULK5	B7Z2I8 B7Z5Q3 B7Z5X9 B7ZAG0 E7ENB6 Q9UPQ7
PDB IDs		6XA6 6XA7 6XA8 7R2M 7R2T 9JK7 9JKA	1UHP 1WH1
Enriched GO Terms of Interacting Partners?		Receptor Clustering Synapse Dystrophin-associated Glycoprotein Complex Syntrophin Complex Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Postsynaptic Density Establishment Of Protein Localization Protein Localization To Membrane Localization Within Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Intracellular Protein Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse Endosomal Transport Establishment Or Maintenance Of Cell Polarity Intracellular Protein Localization Vesicle-mediated Transport Neuromuscular Junction Beta-1 Adrenergic Receptor Binding PDZ Domain Binding Cellular Localization Protein Localization To Cell Junction Neuron Projection Ionotropic Glutamate Receptor Binding Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Cytoplasm Glutamatergic Synapse Neuroligin Family Protein Binding Protein Transport Anchoring Junction Bicellular Tight Junction Vesicle-mediated Transport To The Plasma Membrane Protein Kinase Binding Establishment Of Localization In Cell Positive Regulation Of Neuron Projection Arborization GMP Kinase Activity Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Regulation Of Synapse Organization Ubiquitin-modified Protein Reader Activity Neurotransmitter Receptor Transport To Postsynaptic Membrane GDP Metabolic Process Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Juxtaparanode Region Of Axon Protein-containing Complex Localization Structural Molecule Activity	Epithelial Cell Proliferation Tube Morphogenesis Blood Vessel Morphogenesis Apical Plasma Membrane Animal Organ Morphogenesis Proteoglycan Metabolic Process System Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Activin Receptor Activity, Type II Cell Population Proliferation Proteoglycan Biosynthetic Process Epithelial Tube Morphogenesis Postsynaptic Density Membrane Positive Regulation Of Aorta Morphogenesis Ubiquitin-protein Transferase Activity Serotonergic Neuron Axon Guidance Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Convergent Extension Involved In Neural Plate Elongation Dopaminergic Neuron Axon Guidance Establishment Of Planar Polarity Involved In Neural Tube Closure Cell Pole Cell Migration Involved In Kidney Development Lateral Sprouting Involved In Lung Morphogenesis Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis PDZ Domain Binding Acetate Transport Monocarboxylate:sodium Symporter Activity Short-chain Fatty Acid Transmembrane Transport Organic Acid:sodium Symporter Activity Nitrate Transmembrane Transport Propanoate Transmembrane Transport Short-chain Fatty Acid Transport Propionate Transmembrane Transporter Activity Short-chain Fatty Acid Transmembrane Transporter Activity Nicotinate Transport Iodide Channel Activity Regulation Of Lung Blood Pressure Pulmonary Valve Development Tricuspid Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Aorta Morphogenesis Nervous System Development Apical Cytoplasm Establishment Of Body Hair Planar Orientation Anterior/posterior Pattern Specification Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Chondrocyte Proliferation
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