VANGL2 and ARFRP1

Number of citations of the paper that reports this interaction (PubMedID 23326640)
62

Data Source:
BioGRID (pull down)

		VANGL2	ARFRP1
Description		VANGL planar cell polarity protein 2	ARF related protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Plasma Membrane Cell-cell Junction Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Cell Pole Cell Periphery Apical Cytoplasm Postsynaptic Density Membrane Glutamatergic Synapse	Golgi Apparatus Trans-Golgi Network Cytosol Membrane Trans-Golgi Network Membrane
	Molecular Function	Protein Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding
	Biological Process	Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development Heart Looping Membranous Septum Morphogenesis Muscular Septum Morphogenesis Rho Protein Signal Transduction Anterior/posterior Pattern Specification Heparan Sulfate Proteoglycan Biosynthetic Process Convergent Extension Involved In Neural Plate Elongation Regulation Of Wnt Signaling Pathway Glomerulus Development Regulation Of Actin Cytoskeleton Organization Somatic Stem Cell Population Maintenance Non-canonical Wnt Signaling Pathway Cell Migration Involved In Kidney Development Post-anal Tail Morphogenesis Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Wound Healing Apical Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Somatic Stem Cell Division Establishment Of Body Hair Planar Orientation Digestive Tract Morphogenesis Convergent Extension Involved In Axis Elongation Convergent Extension Involved In Organogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Inner Ear Receptor Cell Development Inner Ear Receptor Cell Stereocilium Organization Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Lateral Sprouting Involved In Lung Morphogenesis Kidney Morphogenesis Cochlea Development Cochlea Morphogenesis Regulation Of Establishment Of Planar Polarity Establishment Of Planar Polarity Involved In Neural Tube Closure Non-motile Cilium Assembly Regulation Of Synapse Pruning	Intracellular Protein Transport Signal Transduction Gastrulation Protein Localization To Golgi Apparatus Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport
Pathways		PCP/CE pathway Asymmetric localization of PCP proteins RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	Retrograde transport at the Trans-Golgi-Network Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive performance ( 19734545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Left-handedness ( 32989287) Multiple sclerosis ( 24076602 31604244) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 30604766) Inflammatory bowel disease ( 28067908) Platelet count ( 32888494) Prostate cancer ( 23535732) Refractive error ( 32231278) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Ulcerative colitis ( 28067908)
Interacting Genes		27 interacting genes: AP1M1 ARFRP1 ARHGEF12 DLG2 DLG4 DVL1 GIPC1 KBTBD7 LIN7A LRRC7 MAGI2 MAGI3 MAST1 MAST2 MPDZ PDZRN3 PTPN13 PTPN4 SCRIB SNTA1 SNTB1 SNTG1 SNTG2 SNX27 SQSTM1 SYNJ2BP VCP	6 interacting genes: AP1G1 AP1M1 CYTH1 GLP1R SMAD4 VANGL2
Entrez ID		57216	10139
HPRD ID		02758	05264
Ensembl ID		ENSG00000162738	ENSG00000101246
Uniprot IDs		A8K4L6 Q9ULK5	A0A384P5U7 B7ZKY8 Q13795
PDB IDs		6XA6 6XA7 6XA8 7R2M 7R2T 9JK7 9JKA
Enriched GO Terms of Interacting Partners?		Receptor Clustering Synapse Dystrophin-associated Glycoprotein Complex Syntrophin Complex Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Postsynaptic Density Establishment Of Protein Localization Protein Localization To Membrane Localization Within Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Intracellular Protein Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse Endosomal Transport Establishment Or Maintenance Of Cell Polarity Intracellular Protein Localization Vesicle-mediated Transport Neuromuscular Junction Beta-1 Adrenergic Receptor Binding PDZ Domain Binding Cellular Localization Protein Localization To Cell Junction Neuron Projection Ionotropic Glutamate Receptor Binding Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Cytoplasm Glutamatergic Synapse Neuroligin Family Protein Binding Protein Transport Anchoring Junction Bicellular Tight Junction Vesicle-mediated Transport To The Plasma Membrane Protein Kinase Binding Establishment Of Localization In Cell Positive Regulation Of Neuron Projection Arborization GMP Kinase Activity Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Regulation Of Synapse Organization Ubiquitin-modified Protein Reader Activity Neurotransmitter Receptor Transport To Postsynaptic Membrane GDP Metabolic Process Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Juxtaparanode Region Of Axon Protein-containing Complex Localization Structural Molecule Activity	Endosome To Melanosome Transport AP-1 Adaptor Complex Clathrin Adaptor Activity Melanosome Assembly Platelet Dense Granule Organization Clathrin-coated Vesicle Membrane Melanosome Organization Pigment Granule Organization Collagen Binding Clathrin-coated Vesicle Secretory Granule Organization Glucagon-like Peptide 1 Receptor Activity Muscle Tissue Morphogenesis Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Synaptic Vesicle Budding From Endosome Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Establishment Of Planar Polarity Involved In Neural Tube Closure Cell Pole Cell Migration Involved In Kidney Development Lateral Sprouting Involved In Lung Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Trans-Golgi Network Membrane Intracellular Protein Transport Glucagon Receptor Activity Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Serotonergic Neuron Axon Guidance Convergent Extension Involved In Neural Plate Elongation Dopaminergic Neuron Axon Guidance Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Basolateral Protein Secretion Golgi Membrane Positive Regulation Of Natural Killer Cell Degranulation Cytoplasmic Vesicle Membrane Response To Psychosocial Stress Positive Regulation Of Luteinizing Hormone Secretion Anterior/posterior Pattern Specification Sulfate Binding Endocardial Cell Differentiation Establishment Or Maintenance Of Cell Polarity Apical Cytoplasm Convergent Extension Involved In Organogenesis Establishment Of Body Hair Planar Orientation Establishment Of Planar Polarity Of Embryonic Epithelium Axonemal Central Apparatus Assembly
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