VANGL2 and MAGI3

Number of citations of the paper that reports this interaction (PMID 15195140)
16

Data Source:
HPRD (in vitro, in vivo)

		VANGL2	MAGI3
Gene Name		VANGL planar cell polarity protein 2	membrane associated guanylate kinase, WW and PDZ domain containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Plasma Membrane Cell-cell Junction Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane ER To Golgi Transport Vesicle Cell Pole	Nucleus Plasma Membrane Tight Junction Membrane
	Molecular Function		Guanylate Kinase Activity Frizzled Binding Protein Binding ATP Binding Protein Complex Scaffold
	Biological Process	Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development Heart Looping Membranous Septum Morphogenesis Muscular Septum Morphogenesis Planar Cell Polarity Pathway Involved In Axis Elongation Rho Protein Signal Transduction Anterior/posterior Pattern Specification Convergent Extension Involved In Neural Plate Elongation Regulation Of Wnt Signaling Pathway Glomerulus Development Regulation Of Actin Cytoskeleton Organization Somatic Stem Cell Maintenance Nonmotile Primary Cilium Assembly Cell Migration Involved In Kidney Development Post-anal Tail Morphogenesis Wound Healing Positive Regulation Of JUN Kinase Activity Apical Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Somatic Stem Cell Division Establishment Of Body Hair Planar Orientation Digestive Tract Morphogenesis Convergent Extension Involved In Axis Elongation Inner Ear Receptor Stereocilium Organization Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Lateral Sprouting Involved In Lung Morphogenesis Kidney Morphogenesis Planar Cell Polarity Pathway Involved In Heart Morphogenesis Cochlea Morphogenesis Establishment Of Planar Polarity Involved In Neural Tube Closure Planar Cell Polarity Pathway Involved In Neural Tube Closure	Apoptotic Process Viral Process Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Nucleotide Phosphorylation
Pathways		Asymmetric localization of PCP proteins Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Cognitive performance ( 19734545)	Bulimia nervosa ( 23568457) Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: DVL1 MAGI3	14 interactors: ADRB1 BAI1 DSCAML1 FZD4 FZD7 GRIN2B LATS1 NRCAM PLXNB3 PTEN PTPRB TGFA TNK2 VANGL2
Entrez ID		57216	260425
HPRD ID		02758	11290
Ensembl ID		ENSG00000162738	ENSG00000081026
Uniprot IDs		A8K4L6 Q9ULK5	Q5TCQ9
PDB IDs			3SOE
Enriched GO Terms of Interacting Partners?		Convergent Extension Involved In Neural Plate Elongation Collateral Sprouting Convergent Extension Involved In Organogenesis Protein Localization To Microtubule Neural Plate Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Protein Kinase Activity Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Kinase Activity Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Convergent Extension Prepulse Inhibition Neural Plate Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein Localization To Cytoskeleton Regulation Of Protein Phosphorylation Cochlea Morphogenesis Startle Response Positive Regulation Of Cellular Protein Metabolic Process Postsynaptic Membrane Organization Non-canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Cytoplasmic Microtubule Organization Social Behavior Axon Extension Regulation Of Phosphorus Metabolic Process Cochlea Development Receptor Clustering Neuromuscular Junction Development Negative Regulation Of Protein Binding Nucleotide Phosphorylation Morphogenesis Of An Epithelial Sheet Neuron Projection Extension Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of JUN Kinase Activity Intracellular Signal Transduction Dendrite Morphogenesis Regulation Of JUN Kinase Activity Regulation Of Cellular Protein Metabolic Process Developmental Cell Growth Canonical Wnt Signaling Pathway Negative Regulation Of Binding Inner Ear Morphogenesis Regulation Of Protein Metabolic Process Neurotransmitter Secretion Regulation Of Embryonic Development Positive Regulation Of Canonical Wnt Signaling Pathway	Cell Morphogenesis Developmental Process Cell Morphogenesis Involved In Differentiation Neuron Differentiation Anatomical Structure Morphogenesis Cell Differentiation Generation Of Neurons System Development Neurogenesis Signaling Negative Regulation Of Cell Adhesion Cell Communication Cell Development Cell Projection Morphogenesis Cell Part Morphogenesis Multicellular Organismal Development Axonogenesis Anatomical Structure Development Neuron Development Axon Development Regulation Of Phosphorus Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Non-canonical Wnt Signaling Pathway Signal Transduction Nervous System Development Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Cell Projection Organization Locomotion Blood Vessel Morphogenesis Negative Regulation Of Cell-substrate Adhesion Regulation Of Phosphorylation Regulation Of Cellular Component Organization Neuron Projection Development Positive Regulation Of Phosphorylation Cardiovascular System Development Positive Regulation Of Protein Modification Process Blood Vessel Development Response To Stimulus Vasculature Development Cellular Response To Stimulus Regulation Of Postsynaptic Membrane Potential Wnt Signaling Pathway Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Multicellular Organismal Response To Stress Regulation Of Cell Adhesion Regulation Of Epithelial Cell Proliferation Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		adds arealization axon axons barrel celsr2 celsr3 conditional contexts forebrain fzd3 guidance guidepost inactivation mimics navigation pcp perturbs planar polarity projections redundantly thalamic thalamocortical thalamus unexpectedly wiring	aberration akt1 akt3 amplifications beyond cbfb competitive confirming deaths deletions discovered erbb2 exome gata3 genomes malignancy map3k1 mexico million notably oestrogen pairs partner pik3ca rearrangements recurrent runx1 somatic vietnam
Tagcloud (Difference) ?		adds arealization axon axons barrel celsr2 celsr3 conditional contexts forebrain fzd3 guidance guidepost inactivation mimics navigation pcp perturbs planar polarity projections redundantly thalamic thalamocortical thalamus unexpectedly wiring	aberration akt1 akt3 amplifications beyond cbfb competitive confirming deaths deletions discovered erbb2 exome gata3 genomes malignancy map3k1 mexico million notably oestrogen pairs partner pik3ca rearrangements recurrent runx1 somatic vietnam
Tagcloud (Intersection) ?