TRIM69 and ATP5MC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)

		TRIM69	ATP5MC1
Description		tripartite motif containing 69	ATP synthase membrane subunit c locus 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting ATP Synthase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Lipid Binding Proton Transmembrane Transporter Activity Proton Channel Activity
	Biological Process	Apoptotic Process Centrosome Cycle Protein Ubiquitination Innate Immune Response Centrosome Separation Protein Localization To Centrosome	Monoatomic Ion Transport Proton Motive Force-driven ATP Synthesis Proton Transmembrane Transport
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Mitochondrial protein import Mitochondrial protein import Formation of ATP by chemiosmotic coupling Cristae formation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate in non-diabetics ( 31451708)
Interacting Genes		55 interacting genes: APP ASNS ATP5MC1 BEX2 BIN3 CDSN DVL1 ETFDH EYA4 FAM110A FAM161A FAM90A1 FKBP1B GEM HAUS1 HGS IYD KLHL38 KRT17 LARP1B LYSMD1 MAGEA4 MAJIN MED20 MID2 NEK8 NTAQ1 PML POLR3K PPP1R18 RECK RINT1 RSPH14 SF1 SF3A3 SKIL SPMIP2 STK3 STK4 STMN3 SYCE2 SYNE4 TNNT2 TRIM44 TRIM54 TRIM55 TRIM63 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N WASHC1 WWOX ZNF483	2 interacting genes: ACTN2 TRIM69
Entrez ID		140691	516
HPRD ID		11518	04428
Ensembl ID		ENSG00000185880	ENSG00000159199
Uniprot IDs		H0YL66 Q86WT6	P05496 Q6FIH7
PDB IDs		4NQJ 6YXE	8H9F 8H9J 8H9M 8H9Q 8H9S 8H9T 8H9U 8H9V 8KHF 8KI3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Ubiquitin Conjugating Enzyme Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein K48-linked Ubiquitination Extrinsic Apoptotic Signaling Pathway Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity MRNA 3'-splice Site Recognition Innate Immune Response Protein Binding Regulation Of Apoptotic Signaling Pathway Canonical Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Protein Polyubiquitination Neural Tube Formation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Ubiquitination Regulation Of Hippo Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Localization To Cytoskeleton Defense Response To Symbiont Defense Response To Other Organism Wnt Signalosome Microtubule Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Ubiquitination Protein Monoubiquitination Protein Localization To Microtubule Supramolecular Fiber Organization Protein Stabilization	Titin Z Domain Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity Microspike Assembly Phospholipase C-activating Angiotensin-activated Signaling Pathway Actin Filament Uncapping FATZ Binding LIM Domain Binding Positive Regulation Of Endocytic Recycling Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Actin Filament Depolymerization Postsynaptic Actin Cytoskeleton Centrosome Separation Titin Binding Postsynaptic Cytoskeleton Organization Angiotensin-activated Signaling Pathway Regulation Of Endocytic Recycling Postsynaptic Density, Intracellular Component Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Protein Depolymerization Pseudopodium Focal Adhesion Assembly Positive Regulation Of Cation Channel Activity Protein Localization To Centrosome Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transport Regulation Of Protein Localization To Cell Surface Cell-substrate Junction Organization Positive Regulation Of Protein-containing Complex Disassembly Cell-substrate Junction Assembly Negative Regulation Of Potassium Ion Transport Positive Regulation Of Transporter Activity Cardiac Muscle Cell Development Sarcomere Organization Structural Constituent Of Muscle Cardiac Cell Development Protein Localization To Cytoskeleton Centrosome Cycle Regulation Of Actin Filament Depolymerization Sarcomere Cortical Actin Cytoskeleton Cytoskeleton Platelet Alpha Granule Lumen Cytoskeletal Protein Binding Striated Muscle Cell Development Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of Transmembrane Transporter Activity Intracellular Protein Localization Filopodium Regulation Of Potassium Ion Transport
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