TRIM69 and EYA4

Number of citations of the paper that reports this interaction (PubMedID 36741265)
38

Data Source:
BioGRID (enzymatic study)

		TRIM69	EYA4
Description		tripartite motif containing 69	EYA transcriptional coactivator and phosphatase 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck	Nucleus Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Apoptotic Process Centrosome Cycle Protein Ubiquitination Innate Immune Response Centrosome Separation Protein Localization To Centrosome	DNA Repair Chromatin Organization DNA Damage Response Visual Perception Anatomical Structure Morphogenesis Cell Differentiation Positive Regulation Of DNA Repair Inner Ear Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Estimated glomerular filtration rate in non-diabetics ( 31451708)	Adverse response to drug ( 30420678) Age-related hearing impairment ( 34108613) Appendicular lean mass ( 33097823) Asthma with severe exacerbations ( 32841424) Atrial fibrillation ( 29892015) Bone mineral density (paediatric, skull) ( 24945404) Chronic pain ( 33685280) Estimated glomerular filtration rate ( 31152163 31015462) Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Glomerular filtration rate (creatinine) ( 28452372) Heel bone mineral density ( 30598549 28869591) Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196 34021172) Hip index ( 34021172) Methadone dose in opioid dependence ( 28115739) Neutrophil count ( 32888494) Protein quantitative trait loci ( 18464913) Response to angiotensin II receptor blocker therapy ( 22566498) Triglyceride levels ( 32203549 32154731) Visceral fat ( 22589738) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count ( 32888494)
Interacting Genes		55 interacting genes: APP ASNS ATP5MC1 BEX2 BIN3 CDSN DVL1 ETFDH EYA4 FAM110A FAM161A FAM90A1 FKBP1B GEM HAUS1 HGS IYD KLHL38 KRT17 LARP1B LYSMD1 MAGEA4 MAJIN MED20 MID2 NEK8 NTAQ1 PML POLR3K PPP1R18 RECK RINT1 RSPH14 SF1 SF3A3 SKIL SPMIP2 STK3 STK4 STMN3 SYCE2 SYNE4 TNNT2 TRIM44 TRIM54 TRIM55 TRIM63 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N WASHC1 WWOX ZNF483	7 interacting genes: AATK CRYAA ERBB3 PLK1 SIX1 TRIM69 UBC
Entrez ID		140691	2070
HPRD ID		11518	04648
Ensembl ID		ENSG00000185880	ENSG00000112319
Uniprot IDs		H0YL66 Q86WT6	A0A0S2Z3Q2 A0A0S2Z3V9 A0A8C8KDW0 B4DIV6 B4DRQ6 E9PLN6 F2Z2Y1 O95677 Q96CJ7
PDB IDs		4NQJ 6YXE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Ubiquitin Conjugating Enzyme Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein K48-linked Ubiquitination Extrinsic Apoptotic Signaling Pathway Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity MRNA 3'-splice Site Recognition Innate Immune Response Protein Binding Regulation Of Apoptotic Signaling Pathway Canonical Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Protein Polyubiquitination Neural Tube Formation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Ubiquitination Regulation Of Hippo Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Localization To Cytoskeleton Defense Response To Symbiont Defense Response To Other Organism Wnt Signalosome Microtubule Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Ubiquitination Protein Monoubiquitination Protein Localization To Microtubule Supramolecular Fiber Organization Protein Stabilization	Cell Death Apoptotic Process Programmed Cell Death Centrosome Separation Protein Localization To Centrosome Protein Localization To Cytoskeleton Centrosome Cycle Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Mesenchyme Development Mesenchymal Cell Proliferation Involved In Ureter Development Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Protein Kinase Activity Synaptonemal Complex Disassembly Microtubule Organizing Center Organization Golgi Inheritance Ureter Smooth Muscle Cell Differentiation Cellular Response To 3,3',5-triiodo-L-thyronine Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Fungiform Papilla Morphogenesis Neuron Apoptotic Process Embryonic Organ Morphogenesis Neuregulin Receptor Activity Protein Tyrosine Kinase Activity Regulation Of Branch Elongation Involved In Ureteric Bud Branching Olfactory Placode Formation Response To 3,3',5-triiodo-L-thyronine Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Facial Nerve Morphogenesis Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Animal Organ Development Kinase Activity Protein Localization To Organelle Protein Ubiquitination Myotome Development Positive Regulation Of Ureteric Bud Formation Trigeminal Ganglion Development ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Negative Regulation Of Neuron Apoptotic Process Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Protein Modification By Small Protein Conjugation Cranial Ganglion Development Sensory Organ Development Protein Localization To Nucleus Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
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