TRIM69 and SF1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TRIM69	SF1
Description		tripartite motif containing 69	splicing factor 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck	Nucleus Nucleoplasm Spliceosomal Complex Ribosome U2AF Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Apoptotic Process Centrosome Cycle Protein Ubiquitination Innate Immune Response Centrosome Separation Protein Localization To Centrosome	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome Negative Regulation Of DNA-templated Transcription Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Primary Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	mRNA Splicing - Major Pathway
Drugs			Artenimol
Diseases
GWAS		Estimated glomerular filtration rate in non-diabetics ( 31451708)	Mean reticulocyte volume ( 32888494) Urate levels ( 21768215)
Interacting Genes		55 interacting genes: APP ASNS ATP5MC1 BEX2 BIN3 CDSN DVL1 ETFDH EYA4 FAM110A FAM161A FAM90A1 FKBP1B GEM HAUS1 HGS IYD KLHL38 KRT17 LARP1B LYSMD1 MAGEA4 MAJIN MED20 MID2 NEK8 NTAQ1 PML POLR3K PPP1R18 RECK RINT1 RSPH14 SF1 SF3A3 SKIL SPMIP2 STK3 STK4 STMN3 SYCE2 SYNE4 TNNT2 TRIM44 TRIM54 TRIM55 TRIM63 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N WASHC1 WWOX ZNF483	90 interacting genes: ALG13 APBB1 APOBEC3C ATXN1 BAG4 BCAS2 BCL2 BUD31 CDC42 CEBPA CEP55 CPSF7 CTBP1 CTTN DCN DDX17 DMRTB1 DUX4L9 EWSR1 EXOSC1 EXOSC8 FAM168A FUS GAS7 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPUL1 IDH3A IL7R ILF3 ITCH KHDRBS2 KPNA1 KRT31 KRTAP26-1 LINC00632 MIR106B MIR155 MIR19B2 MIR34A MIRLET7G MKRN3 NCK2 NEIL3 NFKB1 OGT OSTF1 PDAP1 PLSCR1 PRKG1 PRPF39 PRPF40A PRRC2B PSMA3 PUF60 PUS7 RBFOX2 RBM10 RBM17 RBM4 RBM7 RBMX RBPMS RPA2 RSPH1 SEC23A SF3B1 SF3B4 SFPQ SNRPA TAF15 TCERG1 TFIP11 TNPO2 TRIM23 TRIM69 TTN TXNL4B U2AF2 UBL5 USO1 WBP4 WDR77 WDR83 WWP2 YTHDF1 YTHDF3 ZNF461
Entrez ID		140691	7536
HPRD ID		11518	03306
Ensembl ID		ENSG00000185880	ENSG00000168066
Uniprot IDs		H0YL66 Q86WT6	A0A7P0T9U7 A0A9L9PXE4 B4DX42 H7C561 Q15637
PDB IDs		4NQJ 6YXE	1K1G 1O0P 1OPI 2M09 2M0G 4FXW 4FXX 7VH9 7VPX 8PXX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Ubiquitin Conjugating Enzyme Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein K48-linked Ubiquitination Extrinsic Apoptotic Signaling Pathway Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity MRNA 3'-splice Site Recognition Innate Immune Response Protein Binding Regulation Of Apoptotic Signaling Pathway Canonical Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Protein Polyubiquitination Neural Tube Formation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Ubiquitination Regulation Of Hippo Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Localization To Cytoskeleton Defense Response To Symbiont Defense Response To Other Organism Wnt Signalosome Microtubule Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Ubiquitination Protein Monoubiquitination Protein Localization To Microtubule Supramolecular Fiber Organization Protein Stabilization	RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing MRNA Metabolic Process RNA Binding RNA Metabolic Process Nucleic Acid Binding Regulation Of RNA Splicing Nucleic Acid Metabolic Process Spliceosomal Complex Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Alternative MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression MRNA Binding Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Speck Negative Regulation Of Macromolecule Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of MRNA Metabolic Process U2-type Prespliceosome Identical Protein Binding Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Ribonucleoprotein Complex Negative Regulation Of MRNA Splicing, Via Spliceosome MRNA 3'-UTR Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Splicing
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