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TRIM69 and DVL1
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
TRIM69
DVL1
Gene Name
tripartite motif containing 69
dishevelled segment polarity protein 1
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Plasma Membrane
Nuclear Speck
Cytoplasm
Cytosol
Microtubule
Cytoplasmic Membrane-bounded Vesicle
Lateral Plasma Membrane
Clathrin-coated Vesicle
Axon
Dendrite
Growth Cone
Cytoplasmic Vesicle
Neuronal Cell Body
Synapse
Molecular Function
Ubiquitin-protein Transferase Activity
Zinc Ion Binding
Ligase Activity
Molecular_function
Frizzled Binding
Protein Binding
Enzyme Binding
Protein Kinase Binding
Identical Protein Binding
Rac GTPase Binding
Biological Process
Apoptotic Process
Protein Ubiquitination
Regulation Of Neurotransmitter Levels
Transcription From RNA Polymerase II Promoter
Negative Regulation Of Protein Kinase Activity
Neurotransmitter Secretion
Axon Guidance
Heart Development
Neuromuscular Junction Development
Positive Regulation Of Neuron Projection Development
Wnt Signaling Pathway
Neural Tube Development
Convergent Extension Involved In Neural Plate Elongation
Positive Regulation Of Wnt Signaling Pathway
Cytoplasmic Microtubule Organization
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Nucleus
Social Behavior
Protein Localization To Microtubule
Intracellular Signal Transduction
Receptor Clustering
Positive Regulation Of Transcription, DNA-templated
Collateral Sprouting
Axon Extension
Dendrite Morphogenesis
Synapse Organization
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Prepulse Inhibition
Skeletal Muscle Acetylcholine-gated Channel Clustering
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT mediated activation of DVL
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of DVL
negative regulation of TCF-dependent signaling by DVL-interacting proteins
Signaling by Wnt
Signaling by WNT in cancer
PCP/CE pathway
beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions
22 interactors:
APP
ASNS
ATP5G1
DVL1
FAM110A
FKBP1B
HAUS1
IYD
KRT17
LARP1B
MAGEA4
NEK8
PML
PPP1R18
RECK
RSPH14
SF1
SF3A3
SKIL
SYNE4
TRIM44
ZNF483
35 interactors:
ANXA7
ARRB1
ATN1
AXIN1
BRD7
CCDC88C
CSNK1D
CSNK1E
CSNK2A1
CTNNB1
CXXC4
DAAM1
DAB2
DVL3
DYNLT1
EPS8
FRAT1
HDHD2
HECW1
LRRK2
NCK2
NEDD4
PPM1A
PSMA3
RAC1
SIPA1
SMAD1
SMAD2
SMAD3
SMAD4
SMAD7
TRIM69
USP13
VANGL1
VANGL2
Entrez ID
140691
1855
HPRD ID
11518
03220
Ensembl ID
ENSG00000185880
ENSG00000107404
Uniprot IDs
Q86WT6
O14640
Q86TH3
PDB IDs
Enriched GO Terms of Interacting Partners
?
MRNA 3'-splice Site Recognition
Collateral Sprouting
Maintenance Of Protein Location In Nucleus
Anatomical Structure Development
System Development
Negative Regulation Of Catalytic Activity
Protein Localization To Nucleus
Regulation Of Cell Development
Developmental Process
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Cellular Metabolic Process
Intracellular Receptor Signaling Pathway
Positive Regulation Of Cell Development
Morphogenesis Of An Epithelium
MRNA Splice Site Selection
Multicellular Organismal Development
Organ Development
Positive Regulation Of Neuron Projection Development
Regulation Of Neuron Differentiation
Neuromuscular Junction Development
Cellular Nitrogen Compound Metabolic Process
Epithelium Development
Negative Regulation Of Translation In Response To Oxidative Stress
L-asparagine Biosynthetic Process
Regulation Of Hormone Levels
Anatomical Structure Morphogenesis
Positive Regulation Of Cellular Protein Metabolic Process
Tissue Development
Regulation Of Translation
Spliceosomal Complex Assembly
Positive Regulation Of Cell Projection Organization
Tissue Morphogenesis
Positive Regulation Of Cell Cycle
Regulation Of Proteolysis
Cellular Calcium Ion Homeostasis
Positive Regulation Of Proteolysis
Cell Differentiation
Calcium Ion Homeostasis
Regulation Of Neurogenesis
Positive Regulation Of Protein Metabolic Process
Gene Expression
Cellular Component Assembly
Regulation Of Calcium Ion Transport Into Cytosol
Synaptic Growth At Neuromuscular Junction
Positive Regulation Of Sequestering Of Calcium Ion
Positive Regulation Of Neuron Differentiation
Nitrogen Compound Metabolic Process
Response To Light Stimulus
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Signal Transduction
Positive Regulation Of Wnt Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Regulation Of Cell Morphogenesis
Regulation Of Signaling
Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Canonical Wnt Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Embryonic Pattern Specification
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Signaling
Positive Regulation Of Metabolic Process
Signal Transduction
Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Protein Modification Process
SMAD Protein Complex Assembly
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Cellular Metabolic Process
Signaling
Regulation Of Proteasomal Protein Catabolic Process
Cell Communication
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Phosphorylation
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Regulation Of Proteolysis
Positive Regulation Of Cell Morphogenesis Involved In Differentiation
Positive Regulation Of Cellular Protein Catabolic Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Positive Regulation Of Stem Cell Differentiation
Embryonic Axis Specification
Regulation Of Phosphorus Metabolic Process
Ureteric Bud Development
Mesonephric Tubule Development
Mesonephric Epithelium Development
Kidney Development
Tagcloud
?
1p36
1q36
20p12
2q37
accumulating
boy
brachydactyly
chr1
chr2
chr20
cnv
cnvs
coarctation
deleted
deletion
digit
duplications
dysmorphism
facial
gpcpd1
hdac4
intellectual
malformations
p36
pcrs
phenotypes
simply
syndromic
tumorigenic
Tagcloud (Difference)
?
1p36
1q36
20p12
2q37
accumulating
boy
brachydactyly
chr1
chr2
chr20
cnv
cnvs
coarctation
deleted
deletion
digit
duplications
dysmorphism
facial
gpcpd1
hdac4
intellectual
malformations
p36
pcrs
phenotypes
simply
syndromic
tumorigenic
Tagcloud (Intersection)
?