ZBTB16 and HDAC7

Number of citations of the paper that reports this interaction (PMID 11929873)
31

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		ZBTB16	HDAC7
Gene Name		zinc finger and BTB domain containing 16	histone deacetylase 7
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytosol Plasma Membrane Nuclear Body PML Body Nuclear Speck Transcriptional Repressor Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Double-stranded DNA Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Chromatin Binding Transcription Corepressor Activity Protein Kinase C Binding Protein Binding Protein Kinase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Activating Transcription Factor Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Repressing Transcription Factor Binding 14-3-3 Protein Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mesonephros Development Transcription, DNA-templated Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Anterior/posterior Pattern Specification Protein Ubiquitination Hemopoiesis Myeloid Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of NK T Cell Differentiation Cartilage Development Positive Regulation Of Cartilage Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Transcription, DNA-templated Cell-cell Junction Assembly Notch Signaling Pathway Negative Regulation Of Interleukin-2 Production Negative Regulation Of Osteoblast Differentiation Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Conduct disorder (interaction) ( 18846501)	Obesity-related traits ( 23251661) Urate levels ( 23263486)
Protein-Protein Interactions		111 interactors: ACP5 ADAMTS4 AGTR1 AGTR2 ANAPC5 ANXA7 AR ATP6AP2 ATP7B BCL6 BMI1 CASP3 CCDC109B CCDC130 CCDC85B CD81 CDK1 CDK4 CDKN1A CEBPA CEP70 CEP72 CFH CIDEA COQ6 DLST DNAAF5 DNM2 DPM1 EEF1A1 EIF2S2 ENOX1 EP300 EPN1 ESR1 FAM101B FCHO1 FHL2 FSHR GATA1 GATA2 GCSH GNE GOLGA2 GRB7 GSTM4 HBEGF HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDX ICAM3 IL6 KIAA1549 KRT40 KRTAP4-12 LAMTOR5 LDOC1 LMTK3 LSM2 LYAR MAGEA11 MAP3K3 NCOR1 NCOR2 NR3C1 PAFAH1B3 PARP1 PGAM5 PLSCR1 PMAIP1 PML PNRC2 PSMD11 PSMD2 QTRT1 RAB27A RARA RB1 RUNX1T1 RXRA SH2D4A SIN3A SIN3B SMAD3 SMN1 SP1 SPOP SPRY2 SUMO1 TAB2 TERF1 THNSL2 TK1 TOLLIP TRAF2 TRIM27 TRIM54 TXNIP UBE2I VDR VTA1 WDR33 ZBTB32 ZNF24 ZNF281	26 interactors: ACTN4 BCL6 CALCOCO2 CASP8 EDNRA HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 KAT5 MARK2 MARK3 MEF2A MEF2C NCOR2 PPARD PRKD1 PRKD2 REL RIPPLY1 SIN3A UBE2I YWHAG YWHAQ ZBTB16
Entrez ID		7704	51564
HPRD ID		11762	09133
Ensembl ID		ENSG00000109906	ENSG00000061273
Uniprot IDs		Q05516	J3KPH8 Q8WUI4
PDB IDs		1BUO 1CS3	3C0Y 3C0Z 3C10 3ZNR 3ZNS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Positive Regulation Of Metabolic Process Response To Organic Substance Developmental Process Transcription, DNA-templated Regulation Of Protein Metabolic Process Anatomical Structure Development Regulation Of Metabolic Process System Development Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Histone H4 Deacetylation Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Regulation Of Nitrogen Compound Metabolic Process Histone Deacetylation Positive Regulation Of Cellular Protein Metabolic Process Protein Deacetylation Gene Expression RNA Metabolic Process Immune System Process Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Histone H3 Deacetylation Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Chromatin Organization Biosynthetic Process Histone H3-K9 Modification Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Metabolic Process	Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone H4 Deacetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Histone Deacetylation Protein Deacetylation Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cell Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3 Deacetylation Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Histone H3-K9 Modification System Development Regulation Of Organelle Organization Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Signaling Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process Regulation Of Cell Differentiation Cell Communication Cellular Response To Stimulus RNA Biosynthetic Process Response To Stress Positive Regulation Of Cell Proliferation Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cardiovascular System Development Organelle Organization Regulation Of Gene Expression Anatomical Structure Development
Tagcloud ?		approaches authors craniofacial create decisive dental differentiation discusses engineering excellent functions knowledge medicine necessary oral osteogenic paper processes profound putative regulate reports selected sp1 stem summarizes tp53 transcription transcriptomes	antagonized apicidin attributed deacetylase differentiate dysregulation expanded expansion forkhead foxa2 h3k27 hindering hyperacetylation hypoacetylation mesencephalon mitogenic neuron npcs repressive rescues shrna shrnas transplantable trimethylation upregulates ventral vm
Tagcloud (Difference) ?		approaches authors craniofacial create decisive dental differentiation discusses engineering excellent functions knowledge medicine necessary oral osteogenic paper processes profound putative regulate reports selected sp1 stem summarizes tp53 transcription transcriptomes	antagonized apicidin attributed deacetylase differentiate dysregulation expanded expansion forkhead foxa2 h3k27 hindering hyperacetylation hypoacetylation mesencephalon mitogenic neuron npcs repressive rescues shrna shrnas transplantable trimethylation upregulates ventral vm
Tagcloud (Intersection) ?