ZBTB16 and CRBN

Number of citations of the paper that reports this interaction (PubMedID 33470442)
51

Data Source:
BioGRID (enzymatic study)

		ZBTB16	CRBN
Description		zinc finger and BTB domain containing 16	cereblon
Image
GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Cytosol Nuclear Body PML Body Nuclear Speck Transcription Repressor Complex Protein-containing Complex	Nucleus Cytoplasm Cytosol Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding Type 2 Angiotensin Receptor Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Protein Binding Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Mesonephros Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Central Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Hemopoiesis Myeloid Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Hindlimb Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Ossification Involved In Bone Maturation Regulation Of Cell Differentiation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of NK T Cell Differentiation Cartilage Development Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cartilage Development Regulation Of Multicellular Organismal Development	Protein Ubiquitination Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Monoatomic Ion Transmembrane Transport Locomotory Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Limb Development
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Potential therapeutics for SARS
Drugs			Lenalidomide Thalidomide Pomalidomide
Diseases		Skeletal defects, genital hypoplasia, and mental retardation Acute myeloid leukemia (AML)	Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Basophil count ( 32888494) Chronotype ( 30696823) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Corneal astigmatism ( 29422769) Diisocyanate-induced asthma ( 25918132) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-glioblastoma glioma ( 28346443 26424050) Paneth cell defects in Crohn's disease ( 28352666) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Polycystic ovary syndrome ( 26284813 30566500) Polycystic ovary syndrome (adjusted for age and BMI) ( 34791234) Polycystic ovary syndrome (adjusted for age) ( 34791234) Red blood cell count ( 32888494) Smoking initiation ( 33082346) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Urinary albumin-to-creatinine ratio ( 32600054) White blood cell count ( 27863252 32888494)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 27863252 29403010) White matter integrity ( 23218918)
Interacting Genes		155 interacting genes: ACP5 ADAMTS4 AGTR2 AMOTL2 ANAPC5 ANXA7 ATP6AP2 ATP7B BCL6 BLZF1 BMI1 CARD9 CASP3 CCDC85B CCHCR1 CD81 CDK1 CDK4 CDKN1A CEBPA CEP70 CEP72 CFH CIDEA COG6 COQ6 CRBN CTDSP1 DLST DNAAF5 DNM2 DPM1 EEF1A1 EFHC2 EIF2S2 ENOX1 EP300 EPN1 ERVK-6 ESR1 FAM217B FAM90A1 FCHO1 FHL2 FHL5 FSHR GATA1 GATA2 GCSH GNAO1 GNE GOLGA2 GOLGA6L9 GPANK1 GRB7 GSTM4 HBEGF HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDX HOXA1 HOXC5 HSF2BP ICAM3 IL6 KIAA1549 KIFC3 KRT40 KRTAP4-12 LAMTOR5 LDOC1 LMTK3 LRIG1 LSM2 LYAR MAGEA11 MAP3K3 MCUB MEOX2 MID2 MTUS2 MX1 MYLIP NCOR1 NCOR2 NFKBID NME4 NR3C1 OSBPL3 PAFAH1B3 PARP1 PGAM5 PHF1 PIAS2 PIBF1 PLSCR1 PMAIP1 PML PNRC2 PRKAR1B PSMD11 PSMD2 QTRT1 RAB27A RAB3IP RARA RB1 REL RFLNB RINT1 RUNX1T1 RXRA SH2D4A SIN3A SIN3B SMAD3 SMN1 SP1 SPOP SPRY2 SUMO1 TAB2 TERF1 THNSL2 TK1 TLE5 TOLLIP TRAF1 TRAF2 TRAF4 TRIM21 TRIM23 TRIM27 TRIM54 TTC23 TXNIP UBE2I VDR VTA1 WASHC1 WDR33 YJU2B ZBTB32 ZBTB42 ZNF24 ZNF281 ZNF552 ZNF620 ZNF655	47 interacting genes: APP APPL2 BCL6 BCL6B BSG CSNK1A1 CYP19A1 DNAJA1 EGR1 EGR4 ELF5 GLUL GRB2 GSPT1 GZF1 HDAC6 HIC1 HIC2 HMGB2 HNRNPK HSPA2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 PRKAG1 RBPMS SALL1 SALL3 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 UBE2D3 UBE2G1 WIZ YWHAZ ZBTB16 ZBTB7A ZBTB7B ZFP91 ZMYM2
Entrez ID		7704	51185
HPRD ID		11762	16750
Ensembl ID		ENSG00000109906	ENSG00000113851
Uniprot IDs		A0A024R3C6 A0A0S2Z4J5 Q05516	Q96SW2
PDB IDs		1BUO 1CS3 8YTH	4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 6XK9 7BQU 7BQV 7LPS 7U8F 8CVP 8D7U 8D7V 8D7W 8D7X 8D7Y 8D7Z 8D80 8D81 8DEY 8G66 8OIZ 8OJH 8RQ1 8RQ8 8RQ9 8RQA 8RQC 8TNP 8TNQ 8TNR 8TZX 8U15 8U16 8U17 8UH6 9CUO 9DJT 9DJX 9DQD 9FJX 9GAO
Enriched GO Terms of Interacting Partners?		Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Protein Lysine Deacetylase Activity Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone Deacetylase Activity Histone Deacetylase Complex Regulation Of Primary Metabolic Process Histone Deacetylase Binding Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasm Nucleoplasm DNA-binding Transcription Factor Binding Zinc Ion Binding Negative Regulation Of Gene Expression Nucleus Protein Binding Identical Protein Binding Transcription Coregulator Binding Enzyme Binding Negative Regulation Of Gene Expression, Epigenetic Chromatin Binding Transcription Corepressor Binding Ubiquitin Protein Ligase Binding SUMO Transferase Activity Cytosol Regulation Of Multicellular Organismal Process Epigenetic Regulation Of Gene Expression Transcription Regulator Complex Negative Regulation Of Multicellular Organismal Process Transcription Corepressor Activity Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Deacetylation Rhythmic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Metabolic Process Zinc Ion Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Metal Ion Binding Nucleoplasm RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Cellular Response To Nutrient Levels Regulation Of Signaling Regulation Of Cell Communication Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Regulation Of Signal Transduction Positive Regulation Of RNA Biosynthetic Process Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Sequence-specific Double-stranded DNA Binding Sequence-specific DNA Binding T Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Lymphocyte Differentiation Mesonephros Development Response To Nutrient Levels
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